[#1986-02] Effect of Glucans on the Antitumor Activity of Grifolan, Naohito Ohno et al.

Chem. Pharm. Bull. 1986; 34(5): 2149-54. Effect of Glucans on the Antitumor Activity of Grifolan

Ohno, N(a), Hayashi, M (a), Iino, K (a), Suzuki, I (a), Oikawa, S (b), Sato, K (b), Suzuki, Y (b), Yadomae , T (a)

a)Tokyo College of Pharmacy, b) Nippon Beet Sugar Mfg. Co. Ltd.

The effects of antitumor active [β-1,3-glucan(grifolan)] and inactive [β-1,6-(islandican), α-1,4-(starch)]glucans in mice were compared. β-1,6-Glucan enhanced the antitumor activity of grifolan, whereas  α-1,4-glucan showed a suppressive effect on the antitumor activity of grifolan. When these glucans were injected i.p. into normal mice, the glucans disappeared gradually. The rate of disappearance was in the order  α-1,4 > β-1,6 > β-1,3. Grifolan induced peritoneal exudate cells, but β-1,6 and α-1,4-glucans did not. Only α-1,4-glucan was degradated by the lysate of the peritoneal exudate cells. These results indicate that the antitumor activity of β-1,3-glucan can be positively or negatively modulated by other glucans, and that glucans showing different antitumor effects have a variety of actions and fates in mice. ( Maitake )