[#1985-05] Effect of a polysaccharide fraction from Grifola frondosa on immune response in mice, I. Suzuki et al.

Effect of a polysaccharide fraction from Grifola frondosa on immune response in mice

Suzuki I, Itani T, Ohno N, Oikawa S, Sato K, Miyazaki T, Yadomae T.

Tokyo College of Pharmacy

The biological and immunomodulating activities of polysaccharide fraction (GF-1), an antitumor poysaccharide fraction from cultured fruiting bodies of Grifola frondosa ( maitake ), was examined in mice.  GF-1 showed no cytocidal effect on culturing tumor cells. However, GF-1 induced resistance against Sarcoma 180 in ICR mice which had completely regressed from the tumor by the effect of GF-1. The administration of GF-1 into mice increased the weights or cell numbers of spleen, and peritoneal cavity. GF-1 enhanced the antigen specific antibody response and carbon clearance activity, whereas GF-1 did not show polyclonal B cell activation and mitogenic activities, and the effect on delayed type hypersensitivity.