[#2026-01] Maitake Konno, Sensuke et al....

A lack of specific and effective treatment for Type 2 diabetes has long demanded to establish a better therapeutic modality. As the maitake mushroom extract, SX-fraction (SXF), has been shown to have anti-diabetic activity, we investigated if SXF would demonstrate such an activity in diabetic KK-Ay mice. Test materials included original maitake mushroom (Orig-M), two different doses of SXF [low dose of SXF (L) and high dose of SXF (H)], and Actos  (ACT). Two hundred KK-Ay mice were divided into five experimental groups: (A) Sham (none given), (B) Orig-M, (C) SXF...

[#2025-03] Maitake Konno, Sensuke et al....

It has been long demanded that a better treatment modality for type 2 diabetes mellitus (T2DM) needs to be established, but few suitable regimens have yet been found. We came across the bioactive mushroom extract, SX-fraction (SXF), which appeared to have a hypoglycemic effect. Hence, we investigated if SXF would actually have such an effect, as well as its possible hypoglycemic mechanism. A small-scale clinical study including ten volunteered T2DM patients was conducted. They took a SXF tablet (500 mg) three times a day for 4 weeks, as the fasting blood glucose...

[#2017-02] Maitake He, Xirui et al. Poly...

Grifola frondosa is a widely consumed edible and medicinal fungus, Ancient books record that it can boost qi and fortify the spleen, moisten the lung and protect the liver. Modern people mainly use it to assist in the treatment of diabetes mellitus and various cancers. Over the past three decades, G. frondosa polysaccharides were shown to possess various promising bioactivities, mainly including anti-tumor and immunomodulation, anti-oxidation, anti-hyperglycemia, and meanwhile can effectively act on the skin and hematopoietic stem cells. The purpose of the present review...

[#2014-12] Maitake Konno, Sensuke at al....

Maitake mushroom (Grifola frondosa) is an edible, medicinal mushroom.  It has been extensively studied for the past 30 years, revealing numberous medicinal properties that could provide great health benefits.  Those include various physiological benefits ranging from immunomodulatory and antitumor activities to treatment for diabetes, hypertension, hypercholesterolemia, viral infections (hepatitis B and human immunodeficiency virus), called “maitake D-fraction” and “maitake SX-fraction”.  A number of scientific studies have been performed on...

[#2013-02] Maitake Konno, Sensuke et al ...

The present study suggests that SXF may specifically target the insulin signal pathway, and, in particular, the IR and IRS-1 therein that trigger the subsequent signaling events. As a result, SXF could activate such an impaired signal pathway through high Glc or under a hyperglycemic milieu, thereby ultimately facilitating Glc uptake. This may then account for possible hypoglycemic action of SXF.

BIORESEARCH UPDATE NEWS LETTER #8 Patent...

April 4, 2013 – Japan   SX-fraction (called Grislin in Japan), a proprietary extract derived from Maitake Mushroom, has been patented in three countries.  Japan, the US and Canada, entitled, “A Glycoprotein with Anti-diabetic, Anti-hypertensive, Anti-obesity and Anti-hyperlipidemic effects.”  Its new patent against PCOS (Polycystic Ovary Syndrome) is now registered in the same three countries.  PCOS is a leading cause of infertility, affecting 5-10 % of women of reproductive age and believed to be closely associated with insulin resistance or...