[#2001-01] Effects of maitake (Grifola frondosa) D-Fraction on the carcinoma angiogenesis, K Matsui et al.

Effects of maitake (Grifola frondosa) D-Fraction on the carcinoma angiogenesis

Matsui K, Kodama N, Nanba H.

Department of Microbial chemistry, Kobe Pharmaceutical University

We have reported that D-Fraction extracted from maitake (Grifola frondosa), activates immune competent cells, and indicates anti-tumor activities. The D-Fraction was observed to induce angiogenesis in vivo and to enhance the proliferation capability and migration capability of human vascular endothelial cell in vitro. The D-Fraction also increased plasma vascular endothelial growth factor (VEGF) concentration significantly. Also VEGF and TNF-α production by the activated peritoneal macrophages were enhanced. These results suggest that the anti-tumor activity of the D-Fraction is not only associated with the activation of the immuno-competent cells but also possibly related to the carcinoma angiogenesis induction.