[#2006-07] Meshima: Kojima, Hiroyuki et al ‘Antitumor’

A Case of Spontaneous Regression of Hepatocellular Carcinoma with Multiple Lung Metastases

Hiroyuki Kojima, Noboru Tanigawa, Shuji Kariya, Atsushi Komemushi, Yuzo Shomura, Satoshi Sawada, Eitatsu Arai, and Yoshiro Yokota

Spontaneous regression of hepatocellular carcinoma (HCC) is a rare phenomenon. We present herein the case of a patient with hepatocellular carcinoma with multiple lung metastases in whom malignancy spontaneously regressed after taking Meshima (Phellinus linteus Mycelium). A 79­year-old man consulted our hospital complaining of epigastric discomfort. Abdominal MRI and CT revealed a 3 cm diameter tumor in the liver, and chest CT showed numerous nodular lesions. The levels of alpha-fetoprotein (AFP) and protein induced by vitamin K deficiency or antagonist-II (PIVKA-II) were very high. We diagnosed HCC,with multiple lung metastases, and no therapy was performed. Independently he took exact from Meshima (Phellinus linteus Mycelium) for one month, and 6 months later the tumors appeared to be in complete regression. The mechanism underlying this intriguing phenomenon remains unknown.