{#2024-04} Cordyceps Steven, Lawrence et...

Cordycepin (30 deoxyadenosine) has been widely researched as a potential cancer therapy, but many diverse mechanisms of action have been proposed. Here, we confirm that cordycepin triphosphate is likely to be the active metabolite of cordycepin and that it consistently represses growth factor-induced gene expression. Bioinformatic analysis, quantitative PCR and western blotting confirmed that cordycepin blocks the PI3K/AKT/mTOR and/or MEK/ERK pathways in six cell lines and that AMPK activation is not required. The effects of cordycepin on translation through mTOR...

[#2019-05] Cordyceps Sun, Tingli et al. ...

Cordyceps militaris may show good promise in protecting against chronic kidney disease (CKD) but the molecular mechanism remains unclear. CKD risk is associated with the Toll-like receptor 4/nuclear factor-kappa B (TLR4/NF-κB) signaling pathway. Cordycepin is the main component of Cordyceps militaris and may affect the TLR4/NF-κB pathway. Cordycepin was prepared by preparative HPLC. CKD patients were assigned into Cordyceps militaris (COG, 100 mg daily) and placebo (CG)  groups. Cordycepin activity was measured using human embryo kidney cells (HEK293T). Biochemical...

[#2018-13] Cordyceps Li, Shang-Ze et al....

Cordycepin, or 3′‑deoxyadenosine, is a derivative of the nucleoside adenosine. Initially extracted from the fungus Cordyceps militaris, cordycepin exhibits antitumor activity against certain cancer cell lines; however, the mechanism by which cordycepin counteracts colorectal cancer (CRC) remains poorly understood. The aim of the present study was to explore the underlying mechanisms of cordycepin against human CRC. To investigate the molecular mechanisms of cordycepin against colon cancer and in driving apoptosis, p53 and Bcl‑2‑like protein 4‑null...

[#2018-08] Cordyceps Jin, Ye et al. Anti...

Public interest in complementary and alternative medicine has been increased worldwide, due to its wide applications in cancer prevention and treatment. Cordycepin is one of the most common and crucial types of complementary and alternative medicine. Cordycepin (30-deoxyadenosine), a derivative of adenosine, was first isolated from medicine drug Cordyceps militaris. Cordycepin has been widely used as one compound for antitumor, which has been found to exert antiangiogenic, anti-metastatic, and antiproliferative effects, as well as inducing apoptosis. However, the...

[#2017-12] Cordyceps Hwang, In-Hu et al....

Cellular FLICE inhibitory protein (c-FLIP) is a key anti-apoptotic regulator that associates with the signaling complex downstream of NF-κB, negatively interfering with apoptotic signaling. The role of c-FLIP downregulation by negative regulation of NF-κB signaling during apoptosis is poorly understood. Here, we demonstrate that NF-κB-mediated c-FLIPL negatively regulates the JNK signaling pathway, and that cordycepin treatment of human renal cancer cells leads to apoptosis induction through c-FLIPL inhibition. TNF-α-induced inflammatory microenvironments...

[#2017-11] Cordyceps Panicker, Sangeeth...

Cordyceps is an entomophagous medicinal mushroom that commands a price close to that of Gold or even more, it is believed that the price of this fungus reached USD $20,000 to 40,000 per kg in the international market. Cordyceps spp is mainly endemic to the Tibetian plateau including the adjoining high altitude areas of the central and East Himalayas that includes Nepal, Bhutan and India’s Uttaranchal, Sikkim, Himachal and Arunachal Pradesh. However certain species like Cordyceps militaris is said to be distributed worldwide from 0 to >2000 m a.s.l. The fungus...