[#2015-07] Lion’s Mane Mori, Koich...

ABSTRACT: Chronic low-grade inflammation in the adipose tissue accompanying obesity is thought to be an underlying driver of metabolic diseases. In this study, we aimed to investigate the efficacy of Hericium erinaceus on adipose tissue inflammation. The anti-inflammatory effects of the ethyl acetate soluble fraction of H. erinaceus (EAHE) were examined using cocultures of 3T3-L1 adipocytes and RAW264 macrophages. EAHE significantly suppressed tumor necrosis factor (TNF)-α and interleukin (IL)-6 production in cultured RAW264 macrophages stimulated by...

[#2015-06] Lion’s Mane Okamura, Hi...

The pilot study evaluated the effects of a 4-week administration of H. erinaceus (Amyloban 3399) on female undergraduate students who were likely to have a high incidence of sleep problems.  We assessed the changes in asleep quality and subjective well-being with the GHQ-28 and PSQI (Pittsburgh Sleep Quality Index).  Furthermore, we examined the level of salivary free-MHPG after awakening, which is generally regarded as an accurate index of chronic stress and depressive symptoms and reflects sympathetic nervous system activity.  Thus, we were able to conduct a...

[#2015-05] Lion’s Mane Yao, Wei et...

Accumulating evidence suggests that inflammation plays a role in the pathophysiology of depression and that anti-inflammatory substances have antidepressant effects. Amycenone is obtained from extracts of the Yamabushitake (Hericium erinaceum). The purpose of this study is to examine whether amycenone shows anti-inflammatory and antidepressant effects in an inflammation-induced mouse model of depression. First, we examined the effects of amycenone on the serum levels of the pro-inflammatory cytokine, tumor necrosis factor-α (TNF-α), and the anti-inflammatory cytokine,...

[#2014-10] Lion’s Mane Inanaga, Ka...

Hericium erinaceum (HE) is a unique mushroom for its cognitive function improving actions. HE is known as Yamabushitake in Japanese and Lion’s Mane in English.  Since the early 1990s, Kawagishi and his colleagues have been investigating the role of the compounds derived from HE in the treatment of dementia (Kawagishi et al., 1991; Kawagishi et al., 1992; Kawagishi et al., 2004; Kawagishi et al., 2008). Bioactive substances in HE have the potential to stimulate the production of NGF, repair neuronal damage and improve brain function if the substances in HE are...

[#2014-03] Lion’s Mane Rahman, MA ...

Oxidation of low-density lipoprotein (LDL) has been strongly suggested as the key factor in the pathogenesis of atherosclerosis. Mushrooms have been implicated in having preventive effects against chronic diseases due especially to their antioxidant properties. In this study, in vitro inhibitory effect of Hericium erinaceus on LDL oxidation and the activity of the cholesterol biosynthetic key enzyme, 3-hydroxy-3-methyl glutaryl coenzyme A (HMG Co-A) reductase, was evaluated using five liquid-liquid solvent fractions consisting of methanol : dichloromethane (M : DCM),...

[#2014-02] Lion’s Mane Inanaga, Ka...

Introduction Nerve growth factor (NGF) is considered as a very promising candidate in the treatment of Alzheimer’s disease [1]. However, NGF is a protein that becomes inactive after oral administration. A breakthrough in treatment occurred with the discovery of a class of compounds derived from the Lion’s Mane mushroom (Yamabush­itake, Hericium erinaceum), which stimulate the production of NGF [2,3]. Bioactive substances in H. erinaceum including hericenones, have the potential to repair neurological damage, improve brain function, and possibly prevent and treat...