[#2025-03] Maitake Konno, Sensuke et al....

It has been long demanded that a better treatment modality for type 2 diabetes mellitus (T2DM) needs to be established, but few suitable regimens have yet been found. We came across the bioactive mushroom extract, SX-fraction (SXF), which appeared to have a hypoglycemic effect. Hence, we investigated if SXF would actually have such an effect, as well as its possible hypoglycemic mechanism. A small-scale clinical study including ten volunteered T2DM patients was conducted. They took a SXF tablet (500 mg) three times a day for 4 weeks, as the fasting blood glucose...

[#2025-02] Maitake Konno, Sensuke et al....

We have been studying anticancer effect of Maitake D-fraction (PDF), isolated from maitake mushroom, on various cancer cells in the past 24 years. PDF was highly effective on those cells, profoundly reducing their cell viability. However, we have not yet examined PDF on other cancer cells, particularly pancreatic, cervical, and small-cell lung cancer cells, which had been known to be dismal and deadly. Hence, we investigated if PDF alone or its combination with vitamin C (VC) might have a significant anticancer effect against those cancer cells. Pancreatic cancer...

[#2025-01] Maitake Ding, Yin-Yi et al. S...

Polysaccharide extracted from Grifola frondosa (GFP) was selected in this study. After preliminary separation, four factions were collected, named GFP-F1, GFP-F2, GFP-F3 and GFP-F4. GPF-F2 was further separated into two fractions, namely GFP-N1 and GFP-N2. The molecular weight of GFP-N1 and GFP-N2 was 3.323×103kDa and 10.8 kDa, respectively. GFP-N1 was composed of glucose and galactose and 1→3, 1→4, and 1→6 glycosidic bonds. GFP-N2 was composed of glucose, galactose and mannose and 1→2, 1→3, 1→4, and 1→6 glycosidic bonds. GFP could...

[#2024-01] Maitake Balogh, Gabriela Pha...

This study aimed to analyze the pharmacokinetic parameters of 1,3-beta-glucans from Maitake Pro4X in BALBc mice through oral and Intra Venous (IV) administration. The objectives were to determine the following parameters: Tmax, Cmax, t1/2, ta1/2, Ke, Ka, Clearance, Vd, Cp0, and AUC. Additionally, the tissue distribution of 1,3-beta-glucans after oral and IV administration of Maitake Pro4X was examined to identify the organs involved in absorption, elimination, and distribution. The results comparison  indicated that certain elimination constants were similar in both...

[#2020-01] Maitake Konno, Sensuke et al....

This study shows that anticancer activity of BCNU is significantly potentiated with PDF in T24 cells. This is rather attributed to inactivated Gly-I and increased oxidative stress. Therefore, PDF appears to have a chemosensitizing effect capable of enhancing BCNU cytotoxicity, which may offer an alternative, improved therapeutic option for bladder cancer.

[#2019-03] Coriolus, Maitake Roca-Lema...

Colorectal cancer (CRC) is one of leading cause of mortality in western countries and novel treatment strategies are required. The medicinal application of mushrooms has been used in traditional medicine in many oriental countries. Polysaccharide-rich extracts obtained from certain medicinal mushroom species have shown antitumor effects in different experimental models. In the present study, we have developed polysaccharide-rich extracts from Trametes versicolor (TV) and Grifola frondosa (GF) fruit bodies. We aim to evaluate the anticancer effects of...