[#2009-09] Synergistic potentiation of D...

Synergistic potentiation of D-fraction with vitamin C as possible alternative approach for cancer therapy Sensuke Konno Department of Urology, New York Medical College, Valhalla, NY, USA Abstract: Maitake D-fraction or PDF is the bioactive extract of maitake mushroom (Grifola frondosa) and its active constituent is the protein-bound polysaccharide (proteoglucan), or more specifically known as Beta-glucan. PDF has been extensively studied and a number of its medicinal potentials/properties have been unveiled and demonstrated. Those include various physiological benefits...

[#2009-07] Possible disease remission in...

Possible disease remission in patient with invasive bladder cancer with D-fraction regimen Srinivas Rajamahanty, Brandon Louie, Cormac O’Neill, Muhammad Choudhury, Sensuke Konno Department of Urology, New York Medical College, Valhalla, New York, USA Abstract: Superficial bladder tumors are the most prevalent form of bladder cancers and transurethral resection is the primary surgical modality for those tumors. However, nearly 65% of patients will have tumor recurrence in five years while about 15% will have progression to muscle invasion. Thus, the primary therapeutic...

[#2009-06] Synergistic potentiation of i...

Synergistic potentiation of interferon activity with maitake mushroom D-fraction on bladder cancer cells Brandon Louie, Srinivas Rajamahanty, John Won, Muhammad Choudhury and Sensuke Konno Department of Urology, New York Medical College, Valhalla, NY, USA   To examine whether the combination of interferon (IFN)-α and maitake mushroom D-fraction (PDF), a bioactive mushroom extract, might potentiate the anticancer activity of IFN-α in bladder cancer T24 cells in vitro. IFN-α2B  was able to induce a significant ( ≈ 50%) growth reduction at 20 000 IU/mL, which...

[#2008-05] Possible immunotherapeutic po...

Possible immunotherapeutic potentiation with D-Fraction in prostate cancer cells Paul Pyo, Brandon Louie, Srinivas Rajamahanty, Muhammad Choudhury and Sensuke Konno* Department of Urology, New York Medical College   Abstract Background: Prostate cancer remains the most common malignancy among elderly men and the second leading cause of cancer death in the United States. Although several conventional therapies are currently available, they have a low efficacy and the more effective treatment modalities need to be established. Interferons (IFNs) are one of such options...

[#2007-08] Mushroom-Derived D-fraction a...

Mushroom-Derived D-fraction as Single Agent for the Treatment of Lymphoma in Dogs P.C. Griessmayr, M. Gauthier, L.G. Barber, and S.M. Cotter Background: D-fraction for Pet is a standardized essence extracted from the mushroom Maitake (Grifola frondosa) that has antitumor activity in tumor-bearing mice. In addition, D-fraction induces apoptosis in human prostate and bladder cancer cells and suppresses the proliferation in vitro of several canine tumor cell lines, such as lymphoma (C1-1), mammary gland (CF33), and connective tissue...

[#2007-04] Effect of various natural pro...

Effect of various natural products on growth of bladder cancer cells: two promising mushroom extracts. Konno S New York Medical College; Department of Urology, Valhalla, NY Despite the availability of several therapeutic options, a safer and more effective modality is urgently needed for treatment of bladder cancer. Specific immunotherapy is effective, but severe side effects limit its clinical use and underscore the need for unconventional therapies using less toxic substances. Many natural substances are touted for their medicinal aspects and side effect profiles, and...