[#2009-12] Maitake Beta-Glucan Enhances ...

Maitake Beta-Glucan Enhances Umbilical Cord Blood Stem Cell Transplantation in the NOD/SCID Mouse HONG LIN, ELISA DE STANCHINA, XI KATHY ZHOU, YUHONG SHE, DANTHANH HOANG, SANDY WY CHEUNG, BARRIE CASSILETH, AND SUSANNA CUNNINGHAM-RUNDLES   Beta glucans are cell wall constituents of yeast, fungi and bacteria, as well as mushrooms and barley. Glucans are not expressed on mammalian cells and are recognized as pathogen-associated molecular patterns (PAMPS) by pattern recognition receptors (PRR). Beta glucans have potential activity as bio­logical response modifiers for...

[#2009-11] Maitake beta-glucan enhances ...

Maitake beta-glucan enhances granulopoiesis and mobilization of granulocytes by increasing G-CSF production and modulating CXCR4/SDF-1 expression Koichi Ito, Yuki Masuda, Yoshihiko Yamasaki, Yoshinobu Yokota, Hiroaki Nanba Department of Microbial Chemistry, Kobe Pharmaceutical University,  Japan Abstract Previous studies have presented that Maitake beta-glucan (MD-Fraction) extracted from the fruit body of Grifola frondosa has an anti-tumor effect by activating the immune system. Recently, the stimulating effects of beta-glucans on hematopoiesis were identified as new...

[#2009-10] Characterization and Antitumo...

Characterization and Antitumor Effect of a Novel Polysaccharide from Maitake ( Grifola frondosa ) YUKI MASUDA,*,† AKIHISA MATSUMOTO,‡ TOSHIHIKO TOIDA,‡ TADAO OIKAWA,§KOICHI ITO,# AND HIROAKI NANBA† †Department of Microbial Chemistry, Kobe Pharmaceutical University,  Japan, ‡Graduate School of Pharmaceutical Sciences, Chiba University, Japan, §Department of Life Science and Biotechnology, Faculty of Chemistry, Materials and Bioengineering, Kansai University, Japan, and #Science 2 (G12), School of Medical Science, Gold Coast Campus, Griffith University, ...

[#2009-09] Synergistic potentiation of D...

Synergistic potentiation of D-fraction with vitamin C as possible alternative approach for cancer therapy Sensuke Konno Department of Urology, New York Medical College, Valhalla, NY, USA Abstract: Maitake D-fraction or PDF is the bioactive extract of maitake mushroom (Grifola frondosa) and its active constituent is the protein-bound polysaccharide (proteoglucan), or more specifically known as Beta-glucan. PDF has been extensively studied and a number of its medicinal potentials/properties have been unveiled and demonstrated. Those include various physiological benefits...

[#2009-08] Maitake β-glucan enhances the...

Maitake β-glucan enhances therapeutic effect and reduces myelosupression and nephrotoxicity of cisplatin in mice Yuki Masuda a,*, Munechika Inoue a, Ayu Miyata a, Shigeto Mizuno b, Hiroaki Nanba a a Department of Microbial Chemistry, Kobe Pharmaceutical University, Japan b Department of Medical Pharmaceutics, Kobe Pharmaceutical University, Japan   Cisplatin is broadly used clinically as an anticancer drug. Despite its significant anticancer activity, cisplatin­ induced nephrotoxicity and myelosuppression limit its use. MD-Fraction is glucan purified from maitake...

[#2009-07] Possible disease remission in...

Possible disease remission in patient with invasive bladder cancer with D-fraction regimen Srinivas Rajamahanty, Brandon Louie, Cormac O’Neill, Muhammad Choudhury, Sensuke Konno Department of Urology, New York Medical College, Valhalla, New York, USA Abstract: Superficial bladder tumors are the most prevalent form of bladder cancers and transurethral resection is the primary surgical modality for those tumors. However, nearly 65% of patients will have tumor recurrence in five years while about 15% will have progression to muscle invasion. Thus, the primary therapeutic...