[#2009-09] Synergistic potentiation of D...

Synergistic potentiation of D-fraction with vitamin C as possible alternative approach for cancer therapy Sensuke Konno Department of Urology, New York Medical College, Valhalla, NY, USA Abstract: Maitake D-fraction or PDF is the bioactive extract of maitake mushroom (Grifola frondosa) and its active constituent is the protein-bound polysaccharide (proteoglucan), or more specifically known as Beta-glucan. PDF has been extensively studied and a number of its medicinal potentials/properties have been unveiled and demonstrated. Those include various physiological benefits...

[#2009-08] Maitake β-glucan enhances the...

Maitake β-glucan enhances therapeutic effect and reduces myelosupression and nephrotoxicity of cisplatin in mice Yuki Masuda a,*, Munechika Inoue a, Ayu Miyata a, Shigeto Mizuno b, Hiroaki Nanba a a Department of Microbial Chemistry, Kobe Pharmaceutical University, Japan b Department of Medical Pharmaceutics, Kobe Pharmaceutical University, Japan   Cisplatin is broadly used clinically as an anticancer drug. Despite its significant anticancer activity, cisplatin­ induced nephrotoxicity and myelosuppression limit its use. MD-Fraction is glucan purified from maitake...

[#2009-07] Possible disease remission in...

Possible disease remission in patient with invasive bladder cancer with D-fraction regimen Srinivas Rajamahanty, Brandon Louie, Cormac O’Neill, Muhammad Choudhury, Sensuke Konno Department of Urology, New York Medical College, Valhalla, New York, USA Abstract: Superficial bladder tumors are the most prevalent form of bladder cancers and transurethral resection is the primary surgical modality for those tumors. However, nearly 65% of patients will have tumor recurrence in five years while about 15% will have progression to muscle invasion. Thus, the primary therapeutic...

[#2009-06] Synergistic potentiation of i...

Synergistic potentiation of interferon activity with maitake mushroom D-fraction on bladder cancer cells Brandon Louie, Srinivas Rajamahanty, John Won, Muhammad Choudhury and Sensuke Konno Department of Urology, New York Medical College, Valhalla, NY, USA   To examine whether the combination of interferon (IFN)-α and maitake mushroom D-fraction (PDF), a bioactive mushroom extract, might potentiate the anticancer activity of IFN-α in bladder cancer T24 cells in vitro. IFN-α2B  was able to induce a significant ( ≈ 50%) growth reduction at 20 000 IU/mL, which...

[#2009-05] A phase I/II trial of a polys...

A phase I/II trial of a polysaccharide extract from Maitake mushroom( Grifola frondosa) in breast cancer patients Gary Deng · Hong Lin · Andrew Seidman · Monica Fornier · Gabriella D’Andrea · Kathleen Wesa · Simon Yeung · Susanna Cunningham-Rundles · Andrew J. Vickers · Barrie Cassileth Abstract Background: Cancer patients commonly use dietary supplements to “boost immune function”. A polysaccharide extract from Grifola frondosa (Maitake extract) showed immunomodulatory effects in preclinical studies and there­fore the potential for clinical use. Whether...

[#2008-14] Protein HGFI from the edible ...

Protein HGFI from the edible mushroom Maitake (Grifola frondosa) is a novel 8 kDa class I hydrophobin that forms rodlets in compressed monolayers  Lei Yu,1,2t Baohua Zhang,1 Géza R. Szilvay,2 Ren Sun,1 Janne Jänis,3 Zefang Wang,1 Shuren Feng,1 Haijin Xu,1 Markus B. Linder2 and Mingqiang Qiao1 1College of Life Sciences, Nankai University, 2VTT Biotechnology, Technical Research Centre of Finland 3University of Joensuu, Department of Chemistry Hydrophobins are a group of low-molecular-mass, cysteine-rich proteins that have unusual biophysical properties. They are highly...