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[#2007-10] Enhanced insulin-hypoglycemic...

Enhanced insulin-hypoglycemic activity in rats consuming a specific glycoprotein extracted from maitake mushroom Preuss HG, Echard B, Bagchi D, Perricone NV, Zhuang C Department of Physiology, Georgetown University Medical Center Aim: Intraperitoneal glucose tolerance (ipGTT) and insulin challenge (ICT) tests were implemented to evaluate whether a specific glycoprotein extract of maitake mushroom (Grifola frondosa) known as SX-fraction enhances insulin sensitivity in spontaneously hypertensive rats (SHR). Methods: SHR were divided randomly into a control group, a group...
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[#2007-09] Stimulating Effects of Grifol...

Stimulating Effects of Grifola frondosa (Maitake) on human osteoblastic cell cultures Saif A, Lindequist U, Wende K Institute of Pharmacy, Ernst-Moritz-Arndt University Greifswald The effect of Grifola frondosa (GF – maitake ) total water extract on two osteoblastic cell cultures (HOS58 and SaOS-2) was investigated to determine if this edible medicinal mushroom has osteoinductive properties. The activity of alkaline phosphate and mineralization were used as indicators for the vitality and maturation of bone cells. The cultivation of human osteosarcoma cells HOS58 for...
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[#2007-08] Mushroom-Derived D-fraction a...

Mushroom-Derived D-fraction as Single Agent for the Treatment of Lymphoma in Dogs P.C. Griessmayr, M. Gauthier, L.G. Barber, and S.M. Cotter Background: D-fraction for Pet is a standardized essence extracted from the mushroom Maitake (Grifola frondosa) that has antitumor activity in tumor-bearing mice. In addition, D-fraction induces apoptosis in human prostate and bladder cancer cells and suppresses the proliferation in vitro of several canine tumor cell lines, such as lymphoma (C1-1), mammary gland (CF33), and connective tissue...
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[#2007-07] Enhancement of Umbilical Cord...

Enhancement of Umbilical Cord Blood Cell Hematopoiesis by Maitake Beta-Glucan Is Mediated by Granulocyte Colony-Stimulating Factor Production Lin H(a,b), Cheung SWY(b), Nesin M(b), Cassileth BR(a), Cunningham-Rundles S(b) a)Integrative Medicine Service, Memorial Sloan-Kettering Cancer Center, New York, New York, b)Host Defenses Program, Department of Pediatrics, Cornell University Weill Medical College, New York, New York Maitake beta-glucan (MBG) is an extract from the fruit body of the Grifola frondosa mushroom that is being widely used to treat cancer in Asia. We have...
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[#2007-06] Submerged Production and Char...

Submerged Production and Characterization of Grifola frondosa Polysaccharides – A New Application to Cosmeceuticals Sang Woo Kim, Hye Jin Hwang, Bum Chun Lee and Jong Won Yun Summary Grifola frondosa (maitake) is traditionally called ‘the king of mushrooms’ and ‘the hen of the woods’. Both the fruiting bodies and the mycelium of maitake have been reported to have antitumor and antiviral activities. Recently, submerged culture processes have been developed, with the intention of providing opportunities for increased economic exploita­tion of...
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[#2007-05] Isolation, identification and...

Isolation, identification and function of a novel anti-HSV-1 protein from Grifola frondosa Gu CQ, Li JW, Chao FH, Jin M, Wang XW, Shen ZQ Institute of Environment and Health, PR China A novel antiviral protein was purified from an extract of Grifola frondosa ( maitake ) fruiting bodies using a procedure that included 40% ammonium sulfate precipitation and DEAE-cellulose ion exchange chromatography, and designated GFAHP. This protein inhibited herpes simplex virus type 1 (HSV-1) replication in vitro with an IC50 value of 4.1 μg/ml and a therapeutic index >29.3. Higher...