[#2008-06] Grifola frondosa (Maitake Mus...

Grifola frondosa (Maitake Mushroom) Water Extract Inhibits Vascular Endothelial Growth Factor-Induced Angiogenesis Through Inhibition of Reactive Oxygen Species and Extracellular Signal-Regulated Kinase Phosphorylation Jong-Suk Lee,1 Byung Chul Park,1 Yu Jin Ko,1 Mi Kyoung Choi,1 Han Gon Choi,1 Chul Soon Yong,1 Jae-Sung Lee,2 and Jung-Ae Kim1 1College of Pharmacy and 2School of Food Technology and Food Service Industry, Yeungnam University, Gyeongsan, Republic of Korea ABSTRACT Grifola frondosa, a large edible mushroom also known as maitake, has been used as a health food...

[#2008-05] Possible immunotherapeutic po...

Possible immunotherapeutic potentiation with D-Fraction in prostate cancer cells Paul Pyo, Brandon Louie, Srinivas Rajamahanty, Muhammad Choudhury and Sensuke Konno* Department of Urology, New York Medical College   Abstract Background: Prostate cancer remains the most common malignancy among elderly men and the second leading cause of cancer death in the United States. Although several conventional therapies are currently available, they have a low efficacy and the more effective treatment modalities need to be established. Interferons (IFNs) are one of such options...

[#2007-11] Maitake Yang, Byung-Keun et a...

Chemical characteristics and immuno-modulating activities of exo-biopolymers produced by Grifola frondosa during submerged fermentation process Byung-Keun Yang, Young-Ah Gu, Yong-Tae Jeong, Hun Jeong, Chi-Hyun Song Abstract The immune-modulating activities and chemical characteristics of exo-biopolymer (EX-GF) produced by a submerged mycelial culture of Maitake (Grifola frondosa) were studied. The EX-GF was fractionated into EX-GF-Fr.1, II, and III by Sephadex G-100 gel chromatography. Anti-complementary activity of EX-GF-Fr. III was highest (71.1%) among them, and its...

[#2007-10] Enhanced insulin-hypoglycemic...

Enhanced insulin-hypoglycemic activity in rats consuming a specific glycoprotein extracted from maitake mushroom Preuss HG, Echard B, Bagchi D, Perricone NV, Zhuang C Department of Physiology, Georgetown University Medical Center Aim: Intraperitoneal glucose tolerance (ipGTT) and insulin challenge (ICT) tests were implemented to evaluate whether a specific glycoprotein extract of maitake mushroom (Grifola frondosa) known as SX-fraction enhances insulin sensitivity in spontaneously hypertensive rats (SHR). Methods: SHR were divided randomly into a control group, a group...

[#2007-09] Stimulating Effects of Grifol...

Stimulating Effects of Grifola frondosa (Maitake) on human osteoblastic cell cultures Saif A, Lindequist U, Wende K Institute of Pharmacy, Ernst-Moritz-Arndt University Greifswald The effect of Grifola frondosa (GF – maitake ) total water extract on two osteoblastic cell cultures (HOS58 and SaOS-2) was investigated to determine if this edible medicinal mushroom has osteoinductive properties. The activity of alkaline phosphate and mineralization were used as indicators for the vitality and maturation of bone cells. The cultivation of human osteosarcoma cells HOS58 for...

[#2007-08] Mushroom-Derived D-fraction a...

Mushroom-Derived D-fraction as Single Agent for the Treatment of Lymphoma in Dogs P.C. Griessmayr, M. Gauthier, L.G. Barber, and S.M. Cotter Background: D-fraction for Pet is a standardized essence extracted from the mushroom Maitake (Grifola frondosa) that has antitumor activity in tumor-bearing mice. In addition, D-fraction induces apoptosis in human prostate and bladder cancer cells and suppresses the proliferation in vitro of several canine tumor cell lines, such as lymphoma (C1-1), mammary gland (CF33), and connective tissue...