[#2006-02] Maitake Gu, Chang-Qing et al....

Inhibition of hepatitis B virus by D-fraction from Grifola frondosa: Synergistic effect of combination with interferon-α in HepG2 2.2.15 Gu CQ, Li JW, Chao FH Institute of Health and Environmental Medicine, PR China In this study, D-fraction extracted from Grifola frondosa ( GF-D from maitake ) and its combination with human interferon alpha-2b (IFN) were investigated for the inhibitory effect on hepatitis B virus (HBV) in HepG2 2.2.15 cells (2.2.15 cells). HBV DNA and viral antigens were analyzed by a quantitative real-time polymerase chain reaction and end-point...

[#2005-08] Enhancement of cytotoxicity o...

Enhancement of cytotoxicity of NK cells by D-Fraction, a polysaccharide from Grifola frondosa Kodama N, Asakawa A, Inui A, Masuda Y, Nanba H. Department of Microbial Chemistry, Kobe Pharmaceutical University In innate immunity, activated natural killer (NK) cells attack and damage pathogens such as bacteria and virus without restriction by the MHC antigen. NK cells activated by IL-12 have been reported to recognize and kill tumor cells in perforin-mediated apoptosis. We have reported that D-Fraction, a polysaccharide extracted from the maitake mushroom (Grifola frondosa),...

[#2005-05] Characterization, Occurrence,...

Characterization, Occurrence, and Molecular Cloning of a Lectin from Gnfola frondosa: Jacalin-Related Lectin of Fungal Origin Yoshiho NAGATA,l‘t Masako YAMASHITA,’ Hiroaki HONDA,’ JUT1k0 AKABANE,’ Koichi UEHARA,’ Akihiro SArro,1 Futoshi SumtsA,1 Kozo NISHIBORI,2 and Yasuo OODAIRA2 ‘Department of Bioresources Chemistry, Faculty of Horticulture, Chiba University, 2Section of Research and Development, Yukiguni-Maitake Co., Ltd. A lectin named GFL was isolated from the fruiting body of the basidiomycete mushroom Grifola frondosa, which...

[#2005-04] Are Botanical Glucans Effecti...

Are Botanical Glucans Effective in Enhancing Tumoricidal Cell Activity? Cunningham-Rundles S, Lin H, Cassileth B Department of Pediatrics, The Weill Medical College of Cornell University, New York, NY Studies of nutrient immune interactions have shown that protein calorie malnutrition and micronutrient deficiency impair immune development and immune response especially in critical phases of life. More recently, important data on the role of fatty acids in immune responses has emerged. The question of how or when dietary intervention might augment immune response or reduce...

[#2005-03] Maitake, Lull, Cristina et al...

Anti-inflammatory and Immunomodulating Properties of Fungal Metabolites Cristina Lull,1 Harry J. Wichers,1 and Huub F. J. Savelkoul2 1Agrotechnology and Food Innovations, Wageningen University and Research Center, Bornsesteeg 59, 6708 PD Wageningen, The Netherlands 2Cell Biology and Immunology Group, Wageningen University and Research Center, Marijkeweg 40, 6709 PG Wageningen, The Netherlands Received 22 December 2004; accepted 25 January 2005 We discuss current information on the ability of extracts and isolated metabolites from mushrooms such as Ganoderma lucidum...

[#2005-02] Maitake D-Fraction enhances a...

Maitake D-Fraction enhances antitumor effects and reduces immunosuppression by mitomycin-C in tumor-bearing mice Kodama N, Murata Y, Asakawa A, Inui A, Hayashi M, Sakai N, Nanba H. Department of Microbial Chemistry, Kobe Pharmaceutical University OBJECTIVE: D-Fraction, a polysaccharide extracted from maitake mushrooms (Grifola frondosa), has been reported to exhibit an antitumor effect through activation of immunocompetent cells, including macrophages and T cells, with modulation of the balance between T-helper 1 and 2 cells. We examined whether D-Fraction could decrease...