[#2004-07] Potential growth inhibitory e...

Potential growth inhibitory effect of maitake D-fraction on canine cancer cells Konno S. Department of Urology, New York Medical College The postulated anticancer effect of D-fraction, the bioactive extract of maitake mushroom, on three types (CF33, CF21, and CL-1) of canine cancer cells was evaluated. The effect of D-fraction on several human cancer cells was also investigated. The effect of other β-glucan products was likewise examined. D-fraction was highly effective on the canine cancer cells, either potently inhibiting cell growth or directly killing cells. Similar...

[#2004-06] Administration of a polysacch...

Administration of a polysaccharide from Grifola frondosa stimulates immune function of normal mice Kodama N, Murata Y, Nanba H. Department of Microbial Chemistry, Kobe Pharmaceutical University We have reported that D-Fraction, a polysaccharide extracted from the edible maitake mushroom (Grifola frondosa), activates immunocompetent cells, thereby eliciting antitumor activity. To extend the application of D-Fraction as a nutritional supplement for healthy people as well as treatment for those with cancer, we investigated the effects of D-Fraction on the immune system in...

[#2003-04] Maitake Talpur, Nadeem et al ...

Effects of niacin-bound chromium, Maitake mushroom fraction SX and (-)-hydroxycitric acid on the metabolic syndrome in aged diabetic Zucker fatty rats Talpur N, Echard BW, Yasmin T, Bagchi D, Preuss HG. Department of Physiology and Biophysics, Georgetown University Medical Center Previous studies in our laboratories have demonstrated that niacin-bound chromium (NBC), Maitake mushroom and (-)-hydroxycitric acid (HCA-SX) can ameliorate hypertension, dyslipidemias and diabetes mellitus, and therefore may be useful in weight management. In the present study, we used aged,...

[#2003-03] Maitake Kodama, Noriko et al...

Effect of Maitake (Grifola frondosa) D-Fraction on the activation of NK cells in cancer patients Kodama N, Komuta K, Nanba H. Department of Microbial Chemistry, Kobe Pharmaceutical University Maitake D-Fraction, extracted from maitake mushroom, has been reported to exert its antitumor effect in tumor-bearing mice by enhancing the immune system through activation of macrophages, T cells, and natural killer (NK) cells. In a previous study, the combination of immunotherapy with the maitake D-Fraction and chemotherapy suggested that the D-Fraction may have the potential to...

[#2003-02] Relationship between dendriti...

Relationship between dendritic cells and the D-fraction-induced Th-1 dominant response in BALB/c tumor-bearing mice Harada N, Kodama N, Nanba H. Department of Microbial Chemistry, Kobe Pharmaceutical University Dendritic cells (DCs) are known to not only induce the activation of T cells, but are also associated with the differentiation of T cells. The D-fraction, a β-glucan extracted from maitake (Grifola frondosa) which expresses anti-tumor effects by establishing a helper (Th)-1 dominance in BALB/c mice, enhanced IL-12p70 production by DCs, when the ratio of CD8α(+)...

[#2002-18] Maitake Konno, Sensuke Maitak...

Introduction Despite the medicinal aspects of several mushrooms having been passed down through folklore in the Orient, the scientific study of these mushrooms to explore their biological properties has been initiated only within the past 20 years. A number of researchers have particularly focused their attention on one of these mushrooms called maitake {Grifola frondosa) mushroom. ”Maitake” (pronounced “my-tah-keh”) is an edible, tasty mushroom and literally means “dancing mushroom.” Characteristically, it is a giant mushroom that...