[#2018-09] Maitake Zhang, Michael et al....

Bladder cancer is the second common genitourinary malignancy next to prostate cancer in the United States.1 Nearly 82,000 new cases would be diagnosed and ~ 17,000 people may die this year (2018).1 Approximately 75% of all newly diagnosed cases will present nonmuscle invasive bladder cancer (NMIBC) including stage Ta, T1 and carcinoma in situ,2,3 while other 25% are muscle invasive bladder cancers (MIBCs) or metastatic cancers.3 The primary treatment for NMIBC is transurethral resection of bladder tumor (TURBT);4 however, NMIBC following TURBT has a high recurrence...

[#2018-06] Maitake Mao, Guang-Hua et al....

GP11 had been reported to have effectively anti-tumor activity by improving the immune function in our previous study. To avoid drawbacks of the 5-Fu, GP11 in combinationwith 5-Fuwas investigated in this study. The results demonstrated that such synergism displayed enhance the anti-tumor activity of 5-Fu. Additionally, a strength effectwas also observed in regulating immune function of GP11 and 5-Fu simultaneous administration, such as enhancing seruminterleukin-2 (IL-2) and tumor necrosis factor-alpha (TNF-α) secretion, and increasing immune organs weights....

[#2018-05] Maitake Huang, Jian et al. Gr...

Grifola frondosa polysaccharide (GFP) is the extract of Grifola frondosa. In this study, 50 male wistar rats were separated into S + C, S + T, LG + T, MG + T and HG + T groups to study the effect of GFP on the immune function of heavy load exercising rats. In S + T group, blood neutrophil number, neutrophil phagocytic index and bactericidal capacity decreased significantly, and adhesion function showed remarkable increase after 8 weeks excessive exercise. Low, medium and high doses of GFP were administered to different groups based on gavage. After gavaging GFP during...

[#2018-04] Maitake Li, Qian et al. Purif...

A novel bioactive polysaccharide, GFP-22, was isolated from the fruit bodies of Grifola frondosa by anion-exchange and gel filtration chromatography. Structure of GFP-22 was investigated using gas chromatography–mass spectrometry (GC–MS), methylation, nuclear magnetic resonance (NMR), high-performance size exclusion chromatography-multi-angle laser light scattering-refractive index detector (HPSEC-MALLS-RI) and atomic force microscopy (AFM) analysis. The backbone of GFP-22 is composed of 1,4-β-D-Glcp, 1,3-β-D-Glcp, 1,6-α-D-Glcp, 1,6-α-D-Galp, 1,4,6-α-D-Manp...

[#2018-03] Maitake Alonso, Eliana Noelia...

Triple-negative breast cancer (TNBC) is associated with poor prognosis, high local recurrence rate and high rate of metastasis compared with other breast cancer subtypes. In addition, TNBC lacks a targeted therapy. This scenario highlights the need for novel compounds with high potential for TNBC treatment. In this regard, natural products are important sources of anticancer drugs. D-Fraction, a proteoglucan extracted from the edible and medicinal mushroom Grifola frondosa (Maitake), is a dietary supplement that has been shown to exert both immunostimulatory...

[#2017-05] Maitake Zhang, Yizhi et al. G...

Grifola frondosa, a type of food and medical fungus, has been shown to exhibit various pharmacological activities, including anticancer effects. As the most typical cancer diagnosed among female patients, breast cancer remains a huge concern threatening human health globally. In the present study, the anti-breast cancer effects of Grifola frondosa polysaccharides (GFPs) and the underlying mechanisms were investigated in MCF-7 and MDA-MB-231 cells, as well as in nude mice bearing MCF-7 tumor xenografts. GFPs exerted cytotoxic effects on the cells, as indicated by a decrease...