[#2001-04] Relationship between Solubili...

Relationship between Solubility of Grifolan, a Fungal 1,3-β-D-Glucan, and Production of Tumor Necrosis Factor by Macrophages in Vitro. Ishibashi K, Miura NN, Adachi Y, Ohno N, Yadomae T. Laboratory for Immunopharmacology for Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Science Grifolan, GRN, is a fungal antitumor β-glucan isolated from Grifola frondosa ( maitake ). Various studies suggested that the underlying mechanism of the antitumor activity of GRN is strongly related to immune modulation. In the previous publication (Adachi et al.,...

[#2001-03] Addition of Maitake D-fractio...

Addition of Maitake D-fraction reduces the effective dosage of vancomycin for the treatment of Listeria-infected mice Kodama N, Yamada M, Nanba H. Department of Microbial Chemistry, Kobe Pharmaceutical University Maitake D-fraction, β1,6-glucan having β,3-branches, has been reported to activate the immune system of the host. To elucidate whether the D-fraction can reduce the clinical effective dosage of antibiotics in the treatment of opportunistic bacterial infection, we examined the effects of D-fraction on the treatment of Listeria monocytogenes-infected mice in...

[#2001-02] Maitake Extract and Their The...

Maitake Extract and Their Therapeutic Potential — A Review Mark Mayell Abstract Maiitake (Grifola frondosa) is the Japanese name for an edible fungus with a large fruiting body characterized by overlapping caps. It is a premier culinary as well as medicinal mushroom, Maitake is increasingly being recognized as a potent source of polysaccharide compounds with dramatic health-promoting potential. The most recent development is the MD-fraction, a proprietary maitake extract its Japanese inventors consider to be a notable advance upon the preceding D-fraction. The...

[#2001-01] Effects of maitake (Grifola f...

Effects of maitake (Grifola frondosa) D-Fraction on the carcinoma angiogenesis Matsui K, Kodama N, Nanba H. Department of Microbial chemistry, Kobe Pharmaceutical University We have reported that D-Fraction extracted from maitake (Grifola frondosa), activates immune competent cells, and indicates anti-tumor activities. The D-Fraction was observed to induce angiogenesis in vivo and to enhance the proliferation capability and migration capability of human vascular endothelial cell in vitro. The D-Fraction also increased plasma vascular endothelial growth factor (VEGF)...

[#2000-09] Structures of New Ceramides f...

Structures of New Ceramides from the Fruit Bodies of Grifola frondosa Yasunori YAOITA, Takaaki ISHIZUKA, Rie KAKUDA, Koichi MACHIDA, and Masao KIKUCHI* ToKyo Pharmaceutical University, Japan. Four new phytosphingosine-type ceramides, (25,35,4R)-2-[(2'R)-2'-hydroxydocosanoylamino1-1,3,4-octade­canetriol (1), (2S,3S,4R)-2-[(2'R)-2'-hydroxytricosanoylamino]-1,3,4-octadecanetriol (2), (2S,3S,4R)-2-[(2'R)-2'- hydroxypentacosanoylamino]-1,3,4-octadecanetriol (3) and (2S,3S,4R)-2-[(2'R)-2'-hydroxyhexacosanoylamino]- 1,3,4-octadecanetriol (4), have been isolated from the fruit...

[#2000-08] Angiotensin I-Converting Enzy...

Angiotensin I-Converting Enzyme Inhibitory Peptides from Pepsin Digest of Maitake (Grifola frondosa) Ohtsuru, M(a), Horio, H(b), Masui, H(c) a) Department of Food Science and Nutrition, Mukogawa University, b) Department of Food Science and Nutrition, Nishikyushu University, c) Department of Dietary Life and Food Science, Mukogawa Women’s University Junior College Division Three peptides which inhibit angiotension I-converting enzyme were isolated from maitake (Grifola frondosa) water extract digested by pepsin. Among them,...