[#2017-03] Maitake Alonso, Eliana Noeli...

D-Fraction is protein-bound b-1,6 and b-1,3 glucans (proteoglucan) extracted from the edible and medicinal mushroom Grifola frondosa (Maitake). The antitumoral effect of D-Fraction has long been exclusively attributed to their immunostimulatory capacity. However, in recent years increasing evidence showed that D-Fraction directly affects the viability of canine and human tumor cells, independent of the immune system. Previously, we have reported that D-Fraction modulates the expression of genes associated with cell proliferation, cell death, migration, invasion, and...

[#2017-02] Maitake He, Xirui et al. Poly...

Grifola frondosa is a widely consumed edible and medicinal fungus, Ancient books record that it can boost qi and fortify the spleen, moisten the lung and protect the liver. Modern people mainly use it to assist in the treatment of diabetes mellitus and various cancers. Over the past three decades, G. frondosa polysaccharides were shown to possess various promising bioactivities, mainly including anti-tumor and immunomodulation, anti-oxidation, anti-hyperglycemia, and meanwhile can effectively act on the skin and hematopoietic stem cells. The purpose of the present review...

[#2016-10] Maitake Erjavec, Igor et al. ...

ABSTRACT: Mushroom extracts have shown promising effects in the treatment of cancer and various chronic diseases. Osteoporosis is considered one of the most widespread chronic diseases, for which currently available therapies show mixed results. In this research we investigated the in vitro effects of water extracts of the culinary-medicinal mushrooms Trametes versicolor, Grifola frondosa, Lentinus edodes, and Pleurotus ostreatus on a MC3T3-E1 mouse osteoblast-like cell line, primary rat osteoblasts, and primary rat osteoclasts. In an animal osteoporosis model,...

[#2016-08] Maitake Bao, Hongkun et al. G...

In this paper, we investigated the antidepressant effects of the medical mushroom GF. We found that (1) GF demonstrated antidepressant effects in the TST and FST after 1-day or 5-day treatments; (2) GF led to no hyperactive effects in the OFT; (3)  The antidepressant effects of GF were stronger compared to the other medical mushroom PO; (4) AMPA receptor-specific antagonist GYKI 52466 was able to block the antidepressant effects of GF, suggesting that AMPA receptors are involved in the antidepressant effects of GF.

[#2015-16] Maitake Masuda, Yuki et al. S...

The maturation of dendritic cells into more immunostimulatory dendritic cells by stimulation with different combinations of immunologic agents is expected to provide efficient, adoptive immunotherapy against cancer. Soluble b-glucan maitake D-fraction, extracted from the maitake mushroom Grifola frondosa, acts as a potent immunotherapeutic agent, eliciting innate and adoptive immune responses, thereby contributing to its antitumor activity.

[#2015-04] Maitake Konno, Sensuke et al...

A variety of nutritional supplements are commercially available for the potential therapeutic purpose for dogs and other domestic animals with cancers. However, the efficacy of these supplements on those cancer-bearing animals has not been verified and remains uncertain, due to the lack of the sufficient scientific studies/data. To address this important issue, we examined actual anticancer effects of five selected commercial products on the two types of canine cancer models in vitro. Among them, PET-Fraction (PET-F) obtained from maitake mushroom has been shown to...