[#1987-08] Antitumor Activities of Edibl...

Antitumor Activities of Edible Mushrooms by Oral Administration Mori, K (a), Toyomasu, H (a), Nanba, H (b), Kuroda, H (b) a) The Mushroom Research Institute of Japan, b) Kobe Women’s College of Pharmacy Antitumor activities of edible mushrooms were investigated by breeding mice with the feed containing 10-30% (w/w) powdered fruit bodies. In allogeneic tumor systems (Sarcoma 180 in ICR mice), the tumor growth was suppressed to 40-50% by oral administration of edible mushrooms. While in syngeneic systems (B-16 melanoma or Lewis Lung carcinoma in C57BL/6, Meth-A...

[#1987-07] Host-mediated antitumor effec...

Host-mediated antitumor effect of grifolan NMF-5N, a polysaccharide obtained from Grifola frondosa ( maitake ) Takeyama T, Suzuki I, Ohno N, Oikawa S, Sato K, Ohsawa M, Yadomae T. Tokyo College of Pharmacy The antitumor mechanism of grifolan NMF-5N, a β-1,3-glucan obtained from mycelia of Grifola frondosa, was examined. Grifolan NMF-5N did not show direct cytocidal effect on cultured tumor cells. However, intraperitoneal injection of grifolan NMF-5N increased the number of peritoneal exudate cells and peritoneal adherent cells which showed cytostatic activity towards...

[#1987-06] ANTITUMOR EFFECT OF POLYSACCH...

ANTITUMOR EFFECT OF POLYSACCHARIDE GRIFOLAN NMF-5N ON SYNGENEIC TUMOR IN MICE IWAO SUZUKI,* TAKAHIRO TAKEYAMA,* NAOHITO OHNO,* SHOZO OIKAWA,** KICHIRO SATO,** YOSHIYUKI SUZUKI,** AND TOSHIRO YADOMAE* Tokyo College of Pharmacy, * Horinouchi, Hachioji, Tokyo, 192-03, Japan and Nippon Beet Sugar Mfg., Co. Ltd., ** Chuo-ku, Tokyo, 104, Japan   Antitumor activity of grifolan (from maitake ) NMF-5N, a β-1,3-glucan obtained from mycelia of Grifola frondosa, was examined. Grifolan NMF-5N showed antitumor activities in alloge­neic and syngeneic murine tumor systems. In the...

[[#1987-05] Conformational Changes of th...

Conformational Changes of the Two Different Conformers of Grifolan in Sodium Hydroxide, Urea or Dimethylsulfoxide Solution Ohno, N (a), Adachi, Y(a), Ohsawa, M (b), Sato, K (b),Oikawa, S (b), Yadomae, T (b) a) Tokyo College of Pharmacy, b) Nippon Beet Sugar Mfg. Co. Ltd. Grifolan is an antitumor (1–>3)-β-D-glucan with a β-glucosyl substitution at C-6 of every three main chain units, and is produced by Grifola frondosa ( maitake ). Grifolan possesses two different solid-state conformations, N (native) and H (helix) (N. Ohno et al., Chem. Pharm. Bull. 34, 2555...

[#1987-04] Conformation of Grifolan in t...

Conformation of Grifolan in the Fruit Body of Grifola frondosa Assessed by Carbon-13 Cross Polarization—Magic Angle Spinning Nuclear Magnetic Resonance Spectroscopy NAOHITO OHNO,a MASUMI OHSAWA,b KICHIRO SATO,b SHOZO 01KAWA,b and TOSHIRO YADOMAE*‘b Tokyo College of Pharmacy,” Horinoudri. Hachiofi, Tokyo 192-03, Japan and Nippon Beer Sugar Mfg. Co., Ltd.,’ Kyobashi, Chuo-ku, Tokyo 104. Japan Grifola frondosa ( maitake ) produces an antitumor (1–>3)-β-D-glucan, grifolan, which possesses two kinds of conformations in the solid state, i.e.,...

[#1987-03] Effect of Grifolan on the Asc...

Effect of Grifolan on the Ascites Form of Sarcoma 180 NAOHITO OHNO,b YOSHIYUKI SUZUKI,b KICHIRO SATO,bSHOZO OIKAWA,b and TOSHIRO YADOMAO’b Tokyo College of Pharmacy,’ Horinouchi, Hachioji, Tokyo 192-03, Japan and Nippon Beet Sugar Mfg. Co., Ltd.,’ Kyobashi, Chuo-ku, Tokyo 104, Japan The antitumor activity of a (1–>3)-β-D-glucan, grifolan from Maitake , which was obtained from a fungus, Grifola frondosa, on the ascites form of Sarcoma 180 in ICR mice was examined. Grifolan was effective on the ascites tumor when it was administered before tumor...