[#1988-03] Distribution of Grifolan NMF-...

Distribution of Grifolan NMF-5N (I/B), a Chemically Modified Antitumor β- Glucan in Mice Takahiro TAKEYAMA, Iwao SUZUKI, Naohito OHNO,* Shozo OIKAWA, Kichiro SATO, Masumi OHSAWA,** and Toshiro YADOMAE* Tokyo College of Pharmacy, * Horinouchi, Hachioji, Tokyo, 192-03, Japan and Nippon Beet Sugar Mfg., Co., Ltd., ** Chuo-ku, Tokyo, 104, Japan   The distribution of a 3H-labeled chemically modified antitumor β-glucan, grifolan ( from maitake ) NMF-5N (I/B), in various tissues after an injection into mice was examined in order to obtain information on distribution of the...

[#1988-02] Antitumor Activity Exhibited ...

Antitumor Activity Exhibited by Orally Administered Extract from Fruit Body of Grifola frondosa (Maitake) Hishida, I, Nanba, H, Kuroda, H Laboratory of Microbiology, Kobe Women’s College of Pharmacy, Japan The acid-insoluble, alkali-soluble, hot water-extractable polymer (a polysaccharide containing approximately 30% of protein; D-fraction) obtained from the fruit bodies of Grifola frondosa ( maitake ) exhibited antitumor activities against allogenic and syngeneic tumors on oral administration to mice. Winn assay conducted to examine the tumor growth-suppressing...

[#1988-01] Blood Pressure-Lowering Activ...

Blood Pressure-Lowering Activity Present in the Fruit Body of Grifola frondosa (Maitake) Adachi, K, Nanba, H, Otsuka, M, Kuroda, H Department of Microbiology, Kobe Women’s College of Pharmacy The fruit body of Grifola frondosa (maitake), Basidiomycetes, was confirmed to contain a substance with blood pressure-lowering activity. When powdered fruit body of maitake was given orally to spontaneously hypertensive rats (SHR), blood pressure reduction was observed, in contrast to the control group in which the blood pressure increased with aging. Ether-soluble (ES) and hot...

[#1987-09] Effect of Shiitake (Lentinus ...

Effect of Shiitake (Lentinus edodes) and Maitake (Grifola frondosa) Mushrooms on Blood Pressure and Plasma Lipids of Spontaneously Hypertensive Rats Kabir, Y, Yamaguchi, M, Kimura, S Laboratory of Nutrition, Department of Food Chemistry, Tohoku University To study the effect of Shiitake (Lentinus edodes) and Maitake (Grifola frondosa) on hypertension, spontaneously hypertensive rats were fed a diet containing 5% mushroom powder and 0.5% NaCl solution as drinking water for 9 weeks. The dietary mushrooms decreased the blood pressure. The plasma free cholesterol level...

[#1987-08] Antitumor Activities of Edibl...

Antitumor Activities of Edible Mushrooms by Oral Administration Mori, K (a), Toyomasu, H (a), Nanba, H (b), Kuroda, H (b) a) The Mushroom Research Institute of Japan, b) Kobe Women’s College of Pharmacy Antitumor activities of edible mushrooms were investigated by breeding mice with the feed containing 10-30% (w/w) powdered fruit bodies. In allogeneic tumor systems (Sarcoma 180 in ICR mice), the tumor growth was suppressed to 40-50% by oral administration of edible mushrooms. While in syngeneic systems (B-16 melanoma or Lewis Lung carcinoma in C57BL/6, Meth-A...

[#1987-07] Host-mediated antitumor effec...

Host-mediated antitumor effect of grifolan NMF-5N, a polysaccharide obtained from Grifola frondosa ( maitake ) Takeyama T, Suzuki I, Ohno N, Oikawa S, Sato K, Ohsawa M, Yadomae T. Tokyo College of Pharmacy The antitumor mechanism of grifolan NMF-5N, a β-1,3-glucan obtained from mycelia of Grifola frondosa, was examined. Grifolan NMF-5N did not show direct cytocidal effect on cultured tumor cells. However, intraperitoneal injection of grifolan NMF-5N increased the number of peritoneal exudate cells and peritoneal adherent cells which showed cytostatic activity towards...