[#1985-05] Effect of a polysaccharide fr...

Effect of a polysaccharide fraction from Grifola frondosa on immune response in mice Suzuki I, Itani T, Ohno N, Oikawa S, Sato K, Miyazaki T, Yadomae T. Tokyo College of Pharmacy The biological and immunomodulating activities of polysaccharide fraction (GF-1), an antitumor poysaccharide fraction from cultured fruiting bodies of Grifola frondosa ( maitake ), was examined in mice.  GF-1 showed no cytocidal effect on culturing tumor cells. However, GF-1 induced resistance against Sarcoma 180 in ICR mice which had completely regressed from the tumor by the effect of GF-1. The...

[#1985-04] Neutral and Acidic Antitumor ...

Neutral and Acidic Antitumor Polysaccharides Extracted from Cultured Fruit Bodies of Grifola frondosa NAOHITO OHNO,a KAZUYOSHI IINO,a IWAO SUZUKI,a SHOZO OIKAWA,b KICHIRO SATO,b TOSHIOMIYAZAKI,a and TOSHIRO YADOMAE*’ a Tokyo College of Pharmacy,’ Horinouchi, Hachioji, Tokyo 192-03, Japan and Nippon Beet Sugar Mfg. Co., Ltd.,’ Kyobashi, Chuo-ku, Tokyo 104, Japan Water-soluble glucan fractions extracted from the cultured fruit bodies of Grifola frondosa ( maitake ) with hot water, and with cold and hot sodium hydroxide containing urea showed potent...

[#1985-03] Maitake: Ohno, Naohito et al ...

Structural Characterization and Antitumor Activity of the Extracts from Matted Mycelium of Cultured Grifola frondosa Ohno, N(a), Iino, K(a), Takeyama, T(a), Suzuki, I(a), Sato, K(b), Oikawa, S(b), Miyazaki, T(a), Yadomae, T(a) a) Tokyo College of Pharmacy, b) Nippon Beet Sugar Mfg. Co. Ltd. The fruit body of Grifola frondosa, an edible mushroom, is used as a food in Japan. However, the matted mycelium of the fruit body is not utilized. In this paper, structural characterization and antitumor activity of the extracts from the matted mycelium of this fungus were examined....

[#1985-02] Purification and Structural C...

Purification and Structural Characterization of an Antitumor β-1,3-glucan Isolated from Hot Water Extract of the Fruit Body of Cultured Grifola frondosa Ohno, N(a), Suzuki, I(a), Sato, K(b), Oikawa, S(b), Miyazaki, T(a), Yadomae, T(a) (a) Tokyo College of Pharmacy, (b) Nippon Beet Sugar Mfg. Co, Ltd. Polysaccharides in the hot water extract of the fruit bodies of G. frondosa ( maitake ) contain α-1,4-, α-1,6-, β-1,6- and β-1,3-glucosidic linkages, and include an antitumor-active substance assumed to be a β-1,3-glucan (N. Ohno et al Chem. Pharm. Bull. 32, 1142...

[#1985-01] Structure-Function Relationsh...

Structure-Function Relationship of Antitumor β-1,3-Glucan Obtained from Matted Mycelium of Cultured Grifola frondosa Iino, K(a), Ohno, N(a), Suzuki, I(a), Sata, K(b), Oikawa, S(b), Yadomae, T(a) a) Tokyo College of Pharmacy, b) Nippon Beet Sugar Mfg. Co. Ltd The structure-function relationship of the antitumor 6-branched β-1,3-glucan (grifolan NMF-5N) extracted from the matted mycelium of Grifola frondosa ( maitake ) was examined by using various chemical modification procedures (periodate oxidation, Smith degradation, and enzymic hydrolysis). The antitumor activity of...

[#1984-02] Antitumor activity of a polys...

Antitumor activity of a polysaccharide fraction extracted from cultured fruiting bodies of Grifola frondosa Suzuki I, Itani T, Ohno N, Oikawa S, Sato K, Miyazaki T, Yadomae T. Tokyo College of Pharmacy Antitumor activity of a polysaccharide fraction (GF-1) extracted from cultured fruiting bodies of a fungus, Grifola frondosa ( maitake ), was examined on allogeneic and syngeneic tumors in mice. GF-1 had a marked inhibitory activity against the growth of subcutaneously (s.c.) inoculated Sarcoma 180 by the intraperitoneally (i.p.) injection at 0.5-5.0 mg/mouse for 10...