[#1986-02] Effect of Glucans on the Anti...

Chem. Pharm. Bull. 1986; 34(5): 2149-54. Effect of Glucans on the Antitumor Activity of Grifolan Ohno, N(a), Hayashi, M (a), Iino, K (a), Suzuki, I (a), Oikawa, S (b), Sato, K (b), Suzuki, Y (b), Yadomae , T (a) a)Tokyo College of Pharmacy, b) Nippon Beet Sugar Mfg. Co. Ltd. The effects of antitumor active [β-1,3-glucan(grifolan)] and inactive [β-1,6-(islandican), α-1,4-(starch)]glucans in mice were compared. β-1,6-Glucan enhanced the antitumor activity of grifolan, whereas  α-1,4-glucan showed a suppressive effect on the antitumor activity of grifolan. When these...

[#1986-01] Fractionation and Characteriz...

Fractionation and Characterization of Antitumor Polysaccharides from Maitake, Grifola frondosa Mizuno, T, Ohsawa, K, Hagiwara, N, Kuboyama, R Dept. of Agricultural Chemistry, Faculty of Agriculture, Shizuoka University Three groups of polysaccharides from the edible mushroom, “Maitake”, the cultured fruiting body of Grifola frondosa, were extracted with hot water, 3% NH4-oxalate (100o C), and 5% sodium hydroxide solution (30o C ) in this order. The three fractions, FI, FII, and FIII, were divided into several sub-fractions using various chromatagraphic...

[#1985-07] Structural Characterization o...

Structural Characterization of a Neutral Antitumor Beta-D-Glucan Extracted with Hot Sodium Hydroxide from Cultured Fruit Bodies of Grifola frondosa Iino, K(a), Ohno, N(a), Suzuki, I(a), Miyazaki, T(a), Yadomae, T(a), Oikawa, S(b), Sata, K(b) a) Laboratory of Immunopharmacology of Microbial Proudcts, Tokyo College of Pharmacy, b) Nippon Beet Sugar Mfg. Co. Ltd. The structural characterization of an antitumor beta-D-glucan (grifolan-7N) obtained from the hot sodium hydroxide extract of Grifola frondosa ( maitake ), is described. Grifolan-7N, purified by digestion with...

[#1985-05] Effect of a polysaccharide fr...

Effect of a polysaccharide fraction from Grifola frondosa on immune response in mice Suzuki I, Itani T, Ohno N, Oikawa S, Sato K, Miyazaki T, Yadomae T. Tokyo College of Pharmacy The biological and immunomodulating activities of polysaccharide fraction (GF-1), an antitumor poysaccharide fraction from cultured fruiting bodies of Grifola frondosa ( maitake ), was examined in mice.  GF-1 showed no cytocidal effect on culturing tumor cells. However, GF-1 induced resistance against Sarcoma 180 in ICR mice which had completely regressed from the tumor by the effect of GF-1. The...

[#1985-04] Neutral and Acidic Antitumor ...

Neutral and Acidic Antitumor Polysaccharides Extracted from Cultured Fruit Bodies of Grifola frondosa NAOHITO OHNO,a KAZUYOSHI IINO,a IWAO SUZUKI,a SHOZO OIKAWA,b KICHIRO SATO,b TOSHIOMIYAZAKI,a and TOSHIRO YADOMAE*’ a Tokyo College of Pharmacy,’ Horinouchi, Hachioji, Tokyo 192-03, Japan and Nippon Beet Sugar Mfg. Co., Ltd.,’ Kyobashi, Chuo-ku, Tokyo 104, Japan Water-soluble glucan fractions extracted from the cultured fruit bodies of Grifola frondosa ( maitake ) with hot water, and with cold and hot sodium hydroxide containing urea showed potent...

[#1985-03] Maitake: Ohno, Naohito et al ...

Structural Characterization and Antitumor Activity of the Extracts from Matted Mycelium of Cultured Grifola frondosa Ohno, N(a), Iino, K(a), Takeyama, T(a), Suzuki, I(a), Sato, K(b), Oikawa, S(b), Miyazaki, T(a), Yadomae, T(a) a) Tokyo College of Pharmacy, b) Nippon Beet Sugar Mfg. Co. Ltd. The fruit body of Grifola frondosa, an edible mushroom, is used as a food in Japan. However, the matted mycelium of the fruit body is not utilized. In this paper, structural characterization and antitumor activity of the extracts from the matted mycelium of this fungus were examined....