[#2013-10] Alternative Therapeutic Appro...

Because of a dismal prognosis for advanced renal-cell carcinoma (RCC), an alternative therapeutic approach, using vitamin K3 (VK3) and D-fraction (DF) was investigated. VK3 is a synthetic VK derivative and DF is a bioactive mushroom extract, and they have been shown to have antitumor activity. We examined if the combination of VK3 and DF would exhibit the improved anticancer effect on RCC in vitro. Materials and Methods: Human RCC, ACHN cell line, were treated with varying concentrations of VK3, DF, or a combination of the two. Cell viability was assessed at 72 hours by...

[#2013-03] Maitake, Eliana Noelia Alons...

It is already known that the Maitake (D-Fraction) mushroom is involved in stimulating the immune system and activating certain cells that attack cancer, including macrophages, T-cells, and natural killer cells. According to the U.S. National Cancer Institute, polysaccharide complexes present in Maitake mushrooms appear to have significant anticancer activity. However, the exact molecular mechanism of the Maitake antitumoral effect is still unclear. Previously, we have reported that Maitake (D-Fraction) induces apoptosis in breast cancer cells by activation of...

[#2013-02] Maitake Konno, Sensuke et al ...

The present study suggests that SXF may specifically target the insulin signal pathway, and, in particular, the IR and IRS-1 therein that trigger the subsequent signaling events. As a result, SXF could activate such an impaired signal pathway through high Glc or under a hyperglycemic milieu, thereby ultimately facilitating Glc uptake. This may then account for possible hypoglycemic action of SXF.

BIORESEARCH UPDATE NEWS LETTER #8 Patent...

April 4, 2013 – Japan   SX-fraction (called Grislin in Japan), a proprietary extract derived from Maitake Mushroom, has been patented in three countries.  Japan, the US and Canada, entitled, “A Glycoprotein with Anti-diabetic, Anti-hypertensive, Anti-obesity and Anti-hyperlipidemic effects.”  Its new patent against PCOS (Polycystic Ovary Syndrome) is now registered in the same three countries.  PCOS is a leading cause of infertility, affecting 5-10 % of women of reproductive age and believed to be closely associated with insulin resistance or...

[#2013-01] Maitake Alexander, Bobby et a...

Although several conventional therapeutic options for advanced renal cell carcinoma (RCC) are currently available, the unsatisfactory outcomes demand establishing more effective interventions. D-fraction (PDF), a bioactive proteoglucan of Maitake mushroom, demonstrates anticancer and immunomodulatory activities, which are also shown to be potentiated by vitamin C (VC).We thus hypothesized that a combination of PDF and VC (PDF + VC) could be an alternative approach to more effectively inhibit the growth of RCC. Study design. We examined the dose-dependent effects of PDF +...

BIORESEARCH UPDATE NEWS LETTER #6 Weight...

  Combination for Improved Weight Control with Medicinal Mushrooms and Other Compounds  Ken Babal, C.N.  Most of us know by now that there is no “magic pill” for weight-loss. Reducing body fat requires less food (calories in) along with an increase in energy expenditure (calories out). Nutritionists will disagree about the best proportions of protein, fat and carbohydrate, but there is a strong consensus that limiting high-glycemic foods and controlling blood sugar are critical factors and keys to successful weight management. This is because sharp blood sugar...