[#2022-01] Poria Konno, Sensuke et al. &...

In the present study, the Poria mushroom extract, PE, appears to be a promising natural oral agent capable of significantly reducing cell viability and ultimately leading to ER-induced apoptosis in human RCC, ACHN cells. Thus, PE may have potential clinical implications as an adjuvant agent/supplement offering the therapeutic option for RCC, although more studies are yet required.

[#2020-03] Poria Liao, Yueh-Hsiang et al...

Background. Traditional Chinese medicine (TCM) for the treatment of female infertility remains ambiguous. -e aim of the present case-control study was to examine the association between TCM treatment and successful pregnancy among infertile women. Methods. -is population-based case-control study included the data from 2,627 infertile women with successful pregnancy and 2,627 infertile women without successful pregnancy using datasets from the Longitudinal Health Insurance Database 2000 of the National Health Insurance Research Database during 2000–2010. -e odds ratios...

[#2019-06] Poria Sun, Shan Shan et al. A...

Metabolic syndrome characterized by obesity, hyperglycemia and liver steatosis is becoming prevalent all over the world. Herein, a water insoluble polysaccharide (WIP) was isolated and identified from the sclerotium of Poria cocos, a widely used Traditional Chinese Medicine. WIP was confirmed to be a (1-3)-β-D-glucan with an average Mw of 4.486 × 106 Da by NMR and SEC-RI-MALLS analyses. Furthermore, oral treatment with WIP from P. cocos significantly improved glucose and lipid metabolism and alleviated hepatic steatosis in ob/ob mice. 16S DNA sequencing analysis of...

[#2018-01] Poria Konno, Sensuke et al. A...

Oxidative stress (OXS) has been recently considered as one of anticancer strategies by taking advantage of higher vulnerability of cancer cells (than normal cells) to OXS. In fact, the successful outcomes using OXS have been reported in several cancer cases. A medicinal mushroom extract, PE isolated from Poria mushroom, has been shown to have anticancer/antitumor activity, although its anticancer mechanism has not been fully understood but may involve OXS. We investigated if PE might have anticancer effect on human bladder cancer cells through OXS in vitro. A...

[#2016-07] Poria Konno, Sensuke et al. A...

The present study shows that PE has antioxidant and renoprotective effects against severe oxidative stress exerted by H2O2 or COM (CaOx monohydrate). Such oxidative stress would inhibit glycolysis, deplete cellular ATP, and also interfere with the cell cycle progression (a G1 cell cycle arrest). These adverse effects may account for the resulting cell viability reduction but could be effectively prevented by PE. Therefore, PE is a promising agent with antioxidant activity, capable of protecting renal cells from oxidative assault, and may also reduce the incidence...

[#2015-03] Poria Cheng, Shujie et al. P...

Pachymic acid (PA) is a purified triterpene extracted from medicinal fungus Poria cocos. In this paper, we investigated the anticancer effect of PA on human chemotherapy resistant pancreatic cancer. PA triggered apoptosis in gemcitabine-resistant pancreatic cancer cells PANC-1 and MIA PaCa-2. Comparative gene expression array analysis demonstrated that endoplasmic reticulum (ER) stress was induced by PA through activation of heat shock response and unfolded protein response related genes. Induced ER stress was confirmed by increasing expression of XBP-1s, ATF4,...