[#1994-02] Erinacines A, B and C, strong stimulators of nerve growth factor (NGF)-synthesis, from the mycelia of Hericium erinaceum, Hirokazu Kawagishi et al.

Erinacines A, B and C, strong stimulators of nerve growth factor (NGF)-synthesis,
from the mycelia of Hericium erinaceum.

Hirokazu Kawagishi^*, Atsushi Shimada, Ryoko Shiraia, Kenji Okamotob,
Fumihiro Ojimab, Hideki Sakamotob, Yukio Ishiguro, and Shoei Furukawa

Department of Applied Biological Chemistry, Faculty of Agriculture,
Shizuoka University, 836 Ohya, Shizuoka 422, Japan.
Research Institute, Kagome Co., Ltd.,
17 Nishitomiyama, Nishinasuno-cho, Tochigi 329-27, Japan.
cDepartment of Molecular Biology, Gifu Pharmaceutical University,
5-6-1 Mitahora-Higashi, Gifu 502, Japan.

Abstract: The structures of novel diterpenoids, erinacines A, B, and C, isolated from the cultured mycelia of Hericium erinaceum ( lion’s mane ) were determined by interpretation of the spectral data, and chemical and enzymatic reactions. These compounds showed potent stimulating activity of nerve growth factor (NGF)-synthesis.