[#1996-05] Anti Diabetic Mechanism of Maitake (Grifola frondosa), K. Kubo et al.

Anti Diabetic Mechanism of Maitake (Grifola frondosa)

Kubo, K, Nanba, H

Department of Microbial Chemistry, Kobe Pharmaceutical University

Glucose Tolerance Tests were conducted on KK-A mice, model animals of NIDDM (non-insulin dependent diabetes mellitus). The elevated blood glucose levels after 15 minutes and 30 minutes of Maitake-fed group were 0.64 times and 0.76 times those of the control group respectively, indicating inhibition of a significant blood glucose increase. Insulin receptor capability of liver cells then was examined using the liver perfusion method. Downward regulation was observed among the Maitake-fed group, while a state of tolerance was seen among the control group. Next, glucose absorption activity at the enteron and sucrase activity at the mucosa of the small intestine were examined. Neither inhibition of glucose at the small intestine nor inhibition of sucrase activation was observed when Maitake powder or X-fraction was administered. These results suggested that Maitake’s anti-diabetic activity is not related to the inhibition of glucose absorption at the enteron, but with the process of metabolism of absorbed glucose.