[#2000-08] Angiotensin I-Converting Enzyme Inhibitory Peptides from Pepsin Digest of Maitake (Grifola frondosa), Masaru Otsuru et al.

Angiotensin I-Converting Enzyme Inhibitory Peptides from Pepsin Digest of Maitake (Grifola frondosa)

Ohtsuru, M(a), Horio, H(b), Masui, H(c)

a) Department of Food Science and Nutrition, Mukogawa University, b) Department of Food Science and Nutrition, Nishikyushu University, c) Department of Dietary Life and Food Science, Mukogawa Women’s University Junior College Division

Three peptides which inhibit angiotension I-converting enzyme were isolated from maitake (Grifola frondosa) water extract digested by pepsin. Among them, Lys-Tyr-Thr-Phe-Ala-Val-Thr-Thr-Val-Lys-Thr-Trp-Val had the strongest angiotensinI-converting enzyme inhibitory activity with an IC50 value of 2.6 μM, and the others Gly-Pro-Ser-gly-Pro-Ser-gly, and Tyr-Pro-Ser- also showed inhibitory activity with IC50 values of 2160 and 570 μM, respectively.