[#2008-09] Bioactive Substance from Grifola frondosa (Maitake) Mushroom Inhibits CCAAT Enhancer Binding Protein β and δ Expression on C3H10T1/2 B2C1 Adipocyte Cells, Katsuhiko Minamino et al.

Bioactive Substance from Grifola frondosa (Maitake) Mushroom Inhibits CCAAT Enhancer Binding Protein β and δ Expression on C3H10T1/2 B2C1 Adipocyte Cells

Katsuhiko MINAMINO, Yuri YANAGA and Masaru OHTSURU*

Department of Food Science and Nutrition, School of Human Environmental Science, Mukogawa Women’s
University, Nishinomiya 663-8558, Japan

Summary Bioactive compound substances from Maitake (Grifola frondosa) inhibited adi­pocyte differentiation of B2C1 preadipocytes. This compound is not related to MAP kinase (ERK1 and ERK2) cascades or β-catenin, which inhibit the expression of Glut4, PPARγ and C/EBPα. The compound reduced the expression time of C/EBPβ and C/EBPδ. These results suggest that the inhibitory action of these bioactive compounds on adipocyte differentiation is exhibited through preadipocytes. They cannot induce the expression of PPARγ or C/EBPα because of the reduced expression time of C/EBPβ  and C/EBPδ.