REFERENCES
[#2025-03] Maitake Konno, Sensuke et al. Hypoglycemic Effect of Mushroom Extract (SXF) on Type 2 Diabetes Patients and Its Possible Mechanism
It has been long demanded that a better treatment modality for type 2 diabetes mellitus (T2DM) needs to be established, but few suitable regimens have yet been found. We came across the bioactive mushroom extract, SX-fraction (SXF), which appeared to have a hypoglycemic effect. Hence, we investigated if SXF would actually have such an effect, as well as its possible hypoglycemic mechanism. A small-scale clinical study including ten volunteered T2DM patients was conducted. They took a SXF tablet (500 mg) three times a day for 4 weeks, as...
read more[#2025-02] Maitake Konno, Sensuke et al. Anticancer Activity of Maitake D-Fraction
We have been studying anticancer effect of Maitake D-fraction (PDF), isolated from maitake mushroom, on various cancer cells in the past 24 years. PDF was highly effective on those cells, profoundly reducing their cell viability. However, we have not yet examined PDF on other cancer cells, particularly pancreatic, cervical, and small-cell lung cancer cells, which had been known to be dismal and deadly. Hence, we investigated if PDF alone or its combination with vitamin C (VC) might have a significant anticancer effect against...
read more[#2025-01] Maitake Ding, Yin-Yi et al. Structure characterization of Grifola frondosa polysaccharide….insulin resistance in HFD-fed mice
Polysaccharide extracted from Grifola frondosa (GFP) was selected in this study. After preliminary separation, four factions were collected, named GFP-F1, GFP-F2, GFP-F3 and GFP-F4. GPF-F2 was further separated into two fractions, namely GFP-N1 and GFP-N2. The molecular weight of GFP-N1 and GFP-N2 was 3.323×103kDa and 10.8 kDa, respectively. GFP-N1 was composed of glucose and galactose and 1→3, 1→4, and 1→6 glycosidic bonds. GFP-N2 was composed of glucose, galactose and mannose and 1→2, 1→3, 1→4, and 1→6 glycosidic bonds....
read more{#2024-04} Cordyceps Steven, Lawrence et al. – Cordycepin generally inhibits growth factor signal
Cordycepin (30 deoxyadenosine) has been widely researched as a potential cancer therapy, but many diverse mechanisms of action have been proposed. Here, we confirm that cordycepin triphosphate is likely to be the active metabolite of cordycepin and that it consistently represses growth factor-induced gene expression. Bioinformatic analysis, quantitative PCR and western blotting confirmed that cordycepin blocks the PI3K/AKT/mTOR and/or MEK/ERK pathways in six cell lines and that AMPK activation is not required. The effects of cordycepin...
read more[#2024-03) Cordyceps Ontawang, Atcharaporn et al. A randomized controlled clinical trial examining the effects of Cordyceps militaris beverage on the immune response in healthy adults
Cordyceps militaris (L.) Link (C. militaris) contains various beneficial substances, including polysaccharides (galactomannan), nucleotides (adenosine and cordycepin), cordycepic acid, amino acids, and sterols (ergosterol and beta-sitosterol). It also contains other essential nutrients, such as protein, vitamins (E, K, B1, B2, and B12), and minerals (potassium, sodium, calcium, magnesium, iron, zinc, and selenium). Due to the numerous health benefits of supplements and products containing C. militaris extract, their popularity has...
read more[#2024-02] Lion’s Mane Wang, Tianran et al. Amyloban, extracted from Hericium erinaceus, ameliorates social deficits and suppresses the enhanced dopaminergic system in social defeat stress mice
Social dysfunctions are common in various psychiatric disorders, including depression, schizophrenia, and autism, and are long-lasting and difficult to treat. The development of treatments for social impairment is critical for the treatment of several psychiatric disorders. “Amyloban 3399,” a product extracted from the mushroom Hericium erinaceus, markedly improves social dysfunctions in patients with treatment-resistant schizophrenia and depression. However, the molecular mechanism(s) through which amyloban ameliorates social impairment...
read more[#2024-01] Maitake Balogh, Gabriela Pharmacokinetic Parameters and Tissular Biodistribution of 1,3 β-Glucans
This study aimed to analyze the pharmacokinetic parameters of 1,3-beta-glucans from Maitake Pro4X in BALBc mice through oral and Intra Venous (IV) administration. The objectives were to determine the following parameters: Tmax, Cmax, t1/2, ta1/2, Ke, Ka, Clearance, Vd, Cp0, and AUC. Additionally, the tissue distribution of 1,3-beta-glucans after oral and IV administration of Maitake Pro4X was examined to identify the organs involved in absorption, elimination, and distribution. The results comparison indicated that certain elimination...
read more[#2022-01] Poria Konno, Sensuke et al. – Anticancer Effect of Medicinal Mushroom Extract on Renal
In the present study, the Poria mushroom extract, PE, appears to be a promising natural oral agent capable of significantly reducing cell viability and ultimately leading to ER-induced apoptosis in human RCC, ACHN cells. Thus, PE may have potential clinical implications as an adjuvant agent/supplement offering the therapeutic option for RCC, although more studies are yet required.
read more[#2020-04] Coriolus Jedrzejewski, Tomasz et al., Extract from the Coriolus versicolor Fungus as an Anti Inflammatory Agent.
Chronic inflammation is a well-recognised tumour-enabling component, which includes bioactive molecules from cells infiltrating the tumour microenvironment and increases the risk of cancer progression. Since long-term use of the currently available anti-inflammatory drugs used in cancer therapy causes numerous side effects, the aim of this study was to investigate the effct of an extract isolated from the Coriolus versicolor fungus (CV extract) on HUVEC endothelial cells and MCF-7 breast cancer cells in a pro-inflammatory microenvironment...
read more[#2020-03] Poria Liao, Yueh-Hsiang et al. Traditional Chinese Medicine Treatment Associated with Female Infertility In Taiwan, A Population Based Case Control Study
Background. Traditional Chinese medicine (TCM) for the treatment of female infertility remains ambiguous. -e aim of the present case-control study was to examine the association between TCM treatment and successful pregnancy among infertile women. Methods. -is population-based case-control study included the data from 2,627 infertile women with successful pregnancy and 2,627 infertile women without successful pregnancy using datasets from the Longitudinal Health Insurance Database 2000 of the National Health Insurance Research Database during...
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