[#1994-08] Anti-diabetic activity present in the fruit body of Grifola frondosa (Maitake), Keiko Kubo et al.

Anti-diabetic activity present in the fruit body of Grifola frondosa (Maitake)

Kubo K(a), Aoki H(b), Nanba H(c) a) Yukiguni Maitake Co., Ltd., b) Aoki Clinic, c) Department of Microbial Chemistry, Kobe Pharmaceutical University

 

The fruit body of Grifola frondosa ( maitake ), Basidiomycetes was confirmed to contain substances with anti-diabetic activity. When 1 g/d of powdered fruit body of maitake was given orally to a genetically diabetic mouse (KK-Aγ), blood glucose reduction was observed, in contrast to the control group in which the blood glucose increased with ageing. Moreover, levels of insulin and triglyceride in plasma demonstrated a change similar to blood glucose with feeding of maitake. Ether-ethanol-soluble (ES) and hot water-soluble (WS) fractions were prepared from the fruit body and their hypoglycemic activity was examined. Blood glucose-lowering activity was found when ES-fraction or WS-50% ethanol float (X) fraction was administered orally, but other WS-fractions were inactive. These results suggest that the anti-diabetic activity was present not only in the ES-fraction consisting of lipid but also in the X-fraction of peptidoglycan (sugar:protein = 65:35).