[#1997-07] Poria Cuellar, Maria Jesus et al. Effect of the Basidiomycete Poria cocos on Experimental Dermatitis and Other Inflammatory Conditions

Effect of the Basidiomycete Poria cocos on Experimental Dermatitis and Other Inflammatory Conditions

Maria Jesus CUELLAR, Rosa Maria GINER, Maria del Carmen RECIO, Maria Jose JUST, Salvador MANEZ,* and Jose Luis Rios

Departament de Farmacologia, Facultat de Farmacia, Universitat de Valencia, Valencia, Spain.

The hydroalcoholic extract from Poria cocos was examined for oral and topical anti-inflammatory activities. It proved to be active against carrageenan, arachidonic acid, tetradecanoyl phorbol acetate (TPA) acute edemas, TPA chronic inflammation and oxazolone delayed hypersensitivity in mice. Two lanostane-type triterpenes were isolated and identified by spectroscopic methods as dehydrotumulosic and pachymic acids. Their ID₅₀ on acute TPA edema was 4.7 x 10^{- 3} and 6.8 x 10^-4 μmol/ear, respectively.