REFERENCES
[#2013-20] Cordyceps Tuli, Hardeep et al. Phamacological and therapeutic potential of Cordyceps
Abstract An entomopathogenic fungus, Cordyceps sp. has been known to have numerous pharmacological and therapeutic implications, especially, in terms of human health making it a suitable candidate for ethno-pharmacological use. Main constituent of the extract derived from this fungus comprises a novel bio-metabolite called as Cordycepin (30deoxyadenosine) which has a very potent anti-cancer, antioxidant and anti-inflammatory activities. The current review discusses about the broad spectrum potential of Cordycepin including biological...
read more[#2013-19] Cordyceps Meena, Harsahay et al. Sub-acute toxicity of cultured mycelia, Himalayan entomogenous fungus Cordyceps
Oral administration of laboratory cultured mycelia powder of C. sinensis did not show any sign of toxicity as no significant change was observed in organ weight and serological parameters in rats. However, there was a significant increase in food intake, body weight gain and hematological parameters like WBC, RBC, Hb and lymphocytes in treated groups. Histopathology of vital organs also supported the non toxic effect of C. sinensis. The results conclude that laboratory cultured mycelia powder of C. sinensis is safe and non toxic up to 2 g/kg...
read more[#2013-18] Meshima Kang, Chan Moo et al. Anticancer effect of phellinus linteus potential clinical application in treating pancreatic ductal adenocarcinoma
Pancreatic cancer (ductal adenocarcinoma) is one of the most lethal malignancies in gastrointestinal system. Till now, only margin-negative pancreatectomy is known to be the best treatment option for long-term survival. However, the resection rate is reported to be less than 20%. Even in cases of curative resection, most patients generally experience disease recurrence and ultimately die of metastatic disease. Therefore, surgery alone is not enough and adjuvant systemic chemotherapy should be considered for proper management of pancreatic...
read more[#2013-17] Reishi Wu, Xin et al. Hepatoprotective Effects of Aqueous Extract from Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum on alpha Amanitin-Induced Liver Injury in Mice
ABSTRACT: The Lingzhi or Reishi mushroom Ganoderma lucidum is a well-known traditional medicinal mushroom that has been shown to have obvious hepatoprotective effects. The aim of this study was to evaluate the hepatoprotective effects of G. lucidum aqueous extracts (GLEs) on liver injury induced by α-amanitin (α-AMA) in mice and to analyze the possible hepatoprotective mechanisms related to radical scavenging activity. Mice were treated with α-AMA prepared from Amanita exitialis and then administrated with GLE after the α-AMA injection....
read more[#2013-16] Poria Cheng, Shujie et al. Triterpenes from Poria cocos suppress growth and invasiveness of pancreatic cancer cells through the downregulation of MMP-7
Abstract. Poria cocos is a medicinal mushroom that is widely used in traditional Asian medicine. Here, we show that a characterized mixture of triterpenes extracted from P. cocos (PTE) and three purified triterpenes: pachymic acid (PA), dehydropachymic acid (DPA) and polyporenic acid C (PPAC) suppress the proliferation of the human pancreatic cancer cell lines Panc-1, MiaPaca-2, AsPc-1 and BxPc-3. Moreover, the most effective compound, PA, only slightly affects the proliferation of HPDE-6 normal pancreatic duct epithelial cells. The...
read more[#2013-15] Lion’s Mane Khan, Asaduzzaman et al. Hericium erinaceus: an edible mushroom with medicinal values
Mushrooms are considered as nutritionally functional foods and source of physiologically beneficial medicines. Hericium erinaceus, also known as Lion’s Mane Mushroom or Hedgehog Mushroom, is an edible fungus, which has a long history of usage in traditional Chinese medicine. This mushroom is rich in some physiologically important components, especially β-glucan polysaccharides, which are responsible for anti-cancer, immuno-modulating, hypolipidemic, antioxidant and neuro-protective activities of this mushroom. H. erinaceus has also been...
read more[#2013-14] Reishi Aguirre-Moreno, Alma et al. Anticonvulsant and Neuroprotective Effects of Oligosaccharides from Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Higher Basidiomycetes)
An oligosaccharide fraction isolated from the mycelium of the Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (GLOS) was separated by size-exclusion chromatography. The chemical structure of GLOS consists of a disaccharide repeating unit [-4-b-1-Galf(1-6)-O-(β-Glcp)−1-]n (n=3,4). In addition, this study was undertaken to determine the possible anticonvulsant and neuroprotective effects of GLOS (10–80 mg/kg) on kainic acid (KA)-induced seizures. The behavioral alterations and histopathology of hippocampal neurons were studied. Our...
read more[#2013-12] Maitake Su, Chun-Han et al Inhibitory potential of Grifola frondosa
This study has demonstrated that the nonpolar fraction of GF possesses potent anti-a-glucosidase activity, and its inhibitory kinetics is competitive inhibition. It was as good as acarbose in inhibiting starch digestion in vitro. This study also suggests that oleic acid and linoleic acid could be the major active compounds of GF contributing to the potent anti-a-glucosidase activity
read more[#2013-11] Maitake Lei, Hong et al. MT-α-Glucan from the Fruit Body of the Maitake Medicinal Mushroom Grifola frondosa (Higher Basidiomyetes) Shows Protective Effects for Hypoglycemic Pancreatic β-Cells
The hypoglycemic effect of an α-glucan (designated here as MT-α-glucan) from the fruit body of the Maitake medicinal mushroom, Grifola frondosa, on a murine type 2 diabetes mellitus (T2DM) model was evaluated. Body weight and levels of fasting plasma glucose, glycosylated hemoglobin, triglycerides, cholesterol, free fatty acid, nitric oxide (NO), NO synthase, inducible NO synthase, and hepatic malondialdehyde content decreased significantly when MT-α-glucan was administered to T2DM mice. The content of serum insulin, hepatic glycogen, and...
read more[#2013-10] Alternative Therapeutic Approach to Renal-Cell Carcinoma: Induction of Apoptosis with Combination of Vitamin K3 and D-fraction, M. Degan et al.
Because of a dismal prognosis for advanced renal-cell carcinoma (RCC), an alternative therapeutic approach, using vitamin K3 (VK3) and D-fraction (DF) was investigated. VK3 is a synthetic VK derivative and DF is a bioactive mushroom extract, and they have been shown to have antitumor activity. We examined if the combination of VK3 and DF would exhibit the improved anticancer effect on RCC in vitro. Materials and Methods: Human RCC, ACHN cell line, were treated with varying concentrations of VK3, DF, or a combination of the two. Cell viability...
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