Abstract Background: Polysaccharopeptide (PSP) from Coriolus versicolor (Yunzhi) is used as a supplementary cancer treatment in Asia. The present study aims to investigate whether PSP pre-treatment can increase the response of the human leukemia HL-60 cells to apoptosis induction by Camptothecin (CPT). Methods: We used bivariate bromodeoxyuridine/propidium iodide (BrdUrd/PI) flow cytometry analysis to measure the relative movement (RM) of the BrdUrd positively labeled cells and DNA synthesis time (Ts) on the HL-60 cell line. We used annexin...
read moreHepatoprotective Effect of Syringic Acid and Vanillic Acid on CC14 Induced Liver Injury Ayano ITOH, a Katsuhiro ISODA, a Masuo KONDOH, a Malaya KAWASE, a Akihiro WATARI, a Masakazu KOBAYASHI,b Makoto TAMESADA,b and Kiyohito YAGI * ‘a a Graduate School of Pharmaceutical Sciences, Osaka University; 1-6 Yamada-oka, Saha, Osaka 565-0871, Japan: and b Research and Development Center, Kobayashi Pharmaceutical Co., Ltd.; 1-30-3 Toyokawa, Ibaraki, Osaka 567-0057, Japan. Received December 22, 2009; accepted March 16, 2010; published...
read moreStudies on Bioactive Substances and Medicinal Effects of Reishi, Ganoderma lucidum in Japan Shizuoka University Takashi Mizuno REISHI, the fruiting body of Mannentake, Ganoderma lucidum has been known in Japan, China, and other countries as a food and raw material for the development of drugs. Recent studies have shown that the carcinistaticsubstance in REISHI is a polysaccharide, β-8-(1→3)-D-glucan. This polysaccharide seems to have promise as a new type of carcinostatic agent which might be useful in immunotherapy. Unlike chemicals used...
read moreEffect of Ganoderma lucidum on radioprotection in Mice Yeunhwa GU1,2,5, Takashi NAKAMURA6, Kwang-Ho CHO8, Jung-Sook CHOI7, Toshihiro MAENAKA1, Yuka ITOKAWA1, Takenori YAMASHITA1, Kaori TANO4,5, Ihil-Bong CHOI2, Ki-Mun KANG3, Takeo HASEGAWA1, Masami OSHIMA1, Ikukatsu SUZUKI1, and Torao ISHIDA4,5 1Graduate School of Health Science, Suzuka University of Medical Science 2Department of Radiation Oncology, Catholic University Medical College, Seoul, Korea 3Deptment of Therapeutic Radiology, Gyeongsang National University Hospital, Gyeongsang...
read moreInhibitory Effects of the Methanol Extract of Ganoderma on Mosquito Allergy—Induced Itch-Associated Responses in Mice Tsugunobu Andoh’, Qun Zhang’, Takumi Yamamoto’, Manabu Tayama’, Masao Hattori2, Ken Tanaka³, and Yasushi Kuraishil ‘Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan 2Division of Metabolic Engineering, ³Division of Pharmacognosy, Institute of Natural Medicine, University of Toyama, 2630...
read moreImmunomodulatory Effect of the Polysaccharide-Rich Fraction from Sclerotium of Medicinal Mushroom Poria cocos F.A. Wolf (Aphyllophoromycetideae) on Balb/c Mice Chia-Yu Ma,1 Wan-Ching Chang,2 Hung-Min Chang,2 & James Swi-Bea Wu2,* 1Department of Food and Beverage Management, Technology and Science Institute of Northern Taiwan, Taipei City 112, Taiwan; 2Graduate Institute of Food Science and Technology, National Taiwan University, Taipei City 106, Taiwan ABSTRACT: Dried sclerotia of medicinal mushroom Poria cocos F.A.Wolf were...
read moreMedicinal mushroom Phellinus linteus ( Meshima ) as an alternative cancer therapy (Review) DANIEL SLIVA1‘2‘3 1Cancer Research Laboratory, Methodist Research Institute; 2Department of Medicine, and 3lndiana University Cancer Center, Indiana University School of Medicine, Indianapolis, IN, USA Abstract. Alternative cancer treatment with nutritional/dietary supplements containing a wide variety of herbal products is on the rise in Western countries. Recent epidemiological studies have suggested that mushrooms may prevent against...
read moreProkaryotic expression, purification, and polyclonal antibody production of a hydrophobin from Grifola frondosa Zefang Wang1, Shuren Feng1, Yujian Huang1, Mingqiang Qiao1, Baohua Zhang2, and Haijin Xu2 1The Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, Tianjin 300071, China 2The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, College of Life Sciences, Nankai University, Tianjin 300071, China Hydrophobins are small fungal proteins that...
read moreInfluence of Culinary-Medicinal Maitake Mushroom, Grifola frondosa (Dicks.: Fr.) S.F. Gray (Aphyllophoromycetideae) Polysaccharides on Gene Expression in Jurkat T Lymphocytes Natasa Radic,1* Zala Jevnikar,1 Natasa Obermajer,1,2 Jernej Kristl,1 Janko Kos,1,2 Franc Pohleven,3 & Borut Strukelj1,2 1Department of Pharmaceutical Biology, Faculty of Pharmacy, University of Ljubljana, Slovenia; 2Department of Biotechnology, Jozef Stefan Institute, Slovenia; 3Biotechnical Faculty, University of Ljubljana, Slovenia ABSTRACT: The fruiting...
read moreMaitake Mushroom Extracts Ameliorate Progressive Hypertension and Other Chronic Metabolic Perturbations in Aging Female Rats Harry G. Preuss1~, Bobby Echard1, Debasis Bagchi2, Nicholas V. Perricone3 Georgetown University Medical Center, Department of Physiology, Washington, D.C. USA University of Houston College of Pharmacy, Department of Pharmacological and Pharmaceutical Services, Houston, TX 77204, USA Michigan State University College of Human Medicine, East Lansing, MI USA Abstract Objective: We assessed the ability of two...
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