Objective: The objective of this study was to examine the effect of Cs-4 (Cordyceps sinensis) on exercise performance in healthy elderly subjects. Design: Twenty (20) healthy elderly (age 50–75 years) subjects were enrolled in this double-blind, placebocontrolled, prospective trial. The subjects were taking either Cs-4 333mg or placebo capsules 3 times a day for 12 weeks. Measurement: Subjects received baseline screening including physical examination and laboratory tests. Maximal incremental exercise testing was performed on a...
read moreGanoderma lucidum (G. lucidum), a traditional Chinese medicine, has been used for the treatment of various diseases including cancer and atherosclerosis. In this study, the positive effect of G. lucidum on metabolic syndrome was investigated in more detail by the use of 3T3-L1 pre-adipocyte cells. Treatment of 3T3-L1 cells with G. lucidum extract (GE) significantly promoted adipocyte differentiation and adiponectin production in a dose-dependent manner, as assessed by Oil-Red O staining, quantitative RT-PCR and ELISA. Treatment with GW9662, an...
read moreObstructive jaundice develops after occlusion of the common bile duct. Direct hyperbilirubinaemia, which occurs secondary to the condition, causes various life-threatening pathologies. Cytoprotective effects of Ganoderma lucidum (GL) have previously been shown. In this study, the effects of GL on oxidative stress and oxidant DNA damage in experimental obstructive jaundice were evaluated.
read moreAbstract Background: Polysaccharopeptide (PSP) from Coriolus versicolor (Yunzhi) is used as a supplementary cancer treatment in Asia. The present study aims to investigate whether PSP pre-treatment can increase the response of the human leukemia HL-60 cells to apoptosis induction by Camptothecin (CPT). Methods: We used bivariate bromodeoxyuridine/propidium iodide (BrdUrd/PI) flow cytometry analysis to measure the relative movement (RM) of the BrdUrd positively labeled cells and DNA synthesis time (Ts) on the HL-60 cell line. We used annexin...
read moreHepatoprotective Effect of Syringic Acid and Vanillic Acid on CC14 Induced Liver Injury Ayano ITOH, a Katsuhiro ISODA, a Masuo KONDOH, a Malaya KAWASE, a Akihiro WATARI, a Masakazu KOBAYASHI,b Makoto TAMESADA,b and Kiyohito YAGI * ‘a a Graduate School of Pharmaceutical Sciences, Osaka University; 1-6 Yamada-oka, Saha, Osaka 565-0871, Japan: and b Research and Development Center, Kobayashi Pharmaceutical Co., Ltd.; 1-30-3 Toyokawa, Ibaraki, Osaka 567-0057, Japan. Received December 22, 2009; accepted March 16, 2010; published...
read moreStudies on Bioactive Substances and Medicinal Effects of Reishi, Ganoderma lucidum in Japan Shizuoka University Takashi Mizuno REISHI, the fruiting body of Mannentake, Ganoderma lucidum has been known in Japan, China, and other countries as a food and raw material for the development of drugs. Recent studies have shown that the carcinistaticsubstance in REISHI is a polysaccharide, β-8-(1→3)-D-glucan. This polysaccharide seems to have promise as a new type of carcinostatic agent which might be useful in immunotherapy. Unlike chemicals used...
read moreEffect of Ganoderma lucidum on radioprotection in Mice Yeunhwa GU1,2,5, Takashi NAKAMURA6, Kwang-Ho CHO8, Jung-Sook CHOI7, Toshihiro MAENAKA1, Yuka ITOKAWA1, Takenori YAMASHITA1, Kaori TANO4,5, Ihil-Bong CHOI2, Ki-Mun KANG3, Takeo HASEGAWA1, Masami OSHIMA1, Ikukatsu SUZUKI1, and Torao ISHIDA4,5 1Graduate School of Health Science, Suzuka University of Medical Science 2Department of Radiation Oncology, Catholic University Medical College, Seoul, Korea 3Deptment of Therapeutic Radiology, Gyeongsang National University Hospital, Gyeongsang...
read moreInhibitory Effects of the Methanol Extract of Ganoderma on Mosquito Allergy—Induced Itch-Associated Responses in Mice Tsugunobu Andoh’, Qun Zhang’, Takumi Yamamoto’, Manabu Tayama’, Masao Hattori2, Ken Tanaka³, and Yasushi Kuraishil ‘Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan 2Division of Metabolic Engineering, ³Division of Pharmacognosy, Institute of Natural Medicine, University of Toyama, 2630...
read moreImmunomodulatory Effect of the Polysaccharide-Rich Fraction from Sclerotium of Medicinal Mushroom Poria cocos F.A. Wolf (Aphyllophoromycetideae) on Balb/c Mice Chia-Yu Ma,1 Wan-Ching Chang,2 Hung-Min Chang,2 & James Swi-Bea Wu2,* 1Department of Food and Beverage Management, Technology and Science Institute of Northern Taiwan, Taipei City 112, Taiwan; 2Graduate Institute of Food Science and Technology, National Taiwan University, Taipei City 106, Taiwan ABSTRACT: Dried sclerotia of medicinal mushroom Poria cocos F.A.Wolf were...
read moreMedicinal mushroom Phellinus linteus ( Meshima ) as an alternative cancer therapy (Review) DANIEL SLIVA1‘2‘3 1Cancer Research Laboratory, Methodist Research Institute; 2Department of Medicine, and 3lndiana University Cancer Center, Indiana University School of Medicine, Indianapolis, IN, USA Abstract. Alternative cancer treatment with nutritional/dietary supplements containing a wide variety of herbal products is on the rise in Western countries. Recent epidemiological studies have suggested that mushrooms may prevent against...
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