Maitake beta-glucan promotes recovery of leukocytes and myeloid cell function in peripheral blood from paclitaxel hematotoxicity Hong Lin • Elisa de Stanchina • Xi Kathy Zhou • Feng Hong • Andrew Seidman • Monica Fornier • Wei-Lie Xiao • Edward J. Kennelly • Kathleen Wesa • Barrie R. Cassileth • Susanna Cunningham-Rundles Maitake Abstract Bone marrow myelotoxicity is a major limitation of chemotherapy. While granulocyte colony stimulating factor (G-CSF) treatment is effective, alternative approaches to support...
read moreA polysaccharide extracted from Grifola frondosa enhances the anti-tumor activity of bone marrow-derived dendritic cell-based immunotherapy against murine colon cancer Yuki Masuda • Koichi Ito • Morichika Konishi • Hiroaki Nanba Abstract We previously isolated the novel heteropolysaccharide maitake Z-fraction (MZF) from the maitake mushroom (Grifola frondosa), and demonstrated that MZF significantly inhibited tumor growth by inducing cell-mediated immunity. In this study, we demonstrated that MZF upregulated the...
read moreCommonly consumed and specialty dietary mushrooms reduce cellular proliferation in MCF-7 human breast cancer cells Keith R Martin and Sara K Brophy Nutrition Program, Healthy Lifestyles Research Center, Arizona State University, USA Abstract Worldwide, over one million women will be newly diagnosed with breast cancer in the next year. Moreover, breast cancer is the second leading cause of cancer death in the USA. An accumulating body of evidence suggests that consumption of dietary mushrooms can protect against breast cancer. In this study,...
read moreBoth common and specialty mushrooms inhibit adhesion molecule expression and in vitro binding of monocytes to human aortic endothelial cells in a pro-inflammatory environment Keith R Martin Abstract Background: Cardiovascular disease (CVD) is a leading cause of mortality in the United States as well as globally. Epidemiological studies show that regular fruit and vegetable consumption reduces CVD risk, in part, due to antioxidant activity and immunomodulation since oxidative stress and inflammation are features of atherogenesis. Accumulating...
read moreINORGANIC IODINE CONTENT OF COMMON, EDIBLE MUSHROOMS J. VETTER* Department of Botany, Faculty of Veterinary Science, Szent István University, Hungary The edible mushrooms have different valuable chemical properties (proteins, minerals, aromatic compounds, low lipid and energy contents, etc.) but there are practically no data about the iodine content. The aim of this work was to produce new data on the iodine content of the common edible mushrooms. The inorganic iodine contents of different wild growing (n=49) and cultivated (n=30) mushroom...
read moreGrifola frondosa ( Maitake ) water extract alleviates intestinal inflammation by suppressing TNF-α production and its signaling Jong Suk Lee1*, Su-Young Park1*, Dinesh Thapa1, Mi Kyoung Choi1, Ill-Min Chung2, Young-Joon Park3, Chul Soon Yong1, Han Gon Choi1 and Jung-Ae Kim1 1College of Pharmacy Yeungnam University, Korea 2College of Life and Environmental Sciences Konkuk University Seoul, Korea 3Research Center Samil Pharmaceutical Co. Ltd. Korea Abstract TNF-α is a major cytokine involved in inflammatory bowel disease (IBD). In this...
read morePotential Antitumor Activity of a Low-Molecular-Weight Protein Fraction from Grifola frondosa Through Enhancement of Cytokine Production Noriko Kodama,1,2 Shigeto Mizuno,3 Hiroaki Nanba,4 and Naoaki Saito1 1Laboratory of Molecular Pharmacology, Biosignal Research Center, Kobe University; and Departments of 2Basic Educational Center for Pharmacy and 3Medical Pharmaceutics, 4Kobe Pharmaceutical University, Kobe, Japan ABSTRACT Edible mushrooms contain an abundance of immune-enhancing nutritients. Some of these compounds, referred to as...
read moreAnti-fungal Cell Wall β-glucan Antibody in Animal Sera Ken-ichi Ishibashi, Chikaku Dogasaki, Masuro Motoi, Noriko Miura,Yoshiyuki Adachi, Naohito Ohno β-Glucan is a major component of the cell walls and pathogen-associated microbial patterns of fungi. We previously reported the presence of an antibody which reacts to β-glucan, anti-β-glucan (BG) antibody, in human sera. In livestock and domestic pets, the antibody’s response to fungal cell wall β-glucan is little understood. In this study, we examined the existence and...
read moreMaitake Mushroom (Grifola frondosa) Extract Induces Ovulation in Patients with Polycystic Ovary Syndrome: A Possible Monotherapy and a Combination Therapy After Failure with First-Line Clomiphene Citrate Jui-Tung Chen, MD, PhD, Kunihiko Tominaga, MD, DrPh, PhD, Yoshiaki Sato, MD, PhD,3Hideo Anzai, BS, BS, RPh, and Ryo Matsuoka, MD, PhD Abstract Background: Insulin resistance is a prominent feature of polycystic ovary syndrome (PCOS), and insulin-sensitizing drugs are used to induce ovulation. Recently, it was reported that an extract from...
read moreA Novel Lectin with Antiproliferative and HIV-1 Reverse Transcriptase Inhibitory Activities from Dried Fruiting Bodies of the Monkey Head Mushroom Hericium erinaceum (Lion’s Mane Mushroom) Yanrui Li,1 Guoqing Zhang, 1 Tzi Bun Ng,2 and Hexiang Wang, 1 ‘ State Key Laboratory for Agrobiotechnology, Department of Microbiology, China Agricultural University, China 2 School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong A lectin designated as Hericium erinaceum agglutinin (HEA) was...
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