Characterization and Antitumor Effect of a Novel Polysaccharide from Maitake ( Grifola frondosa ) YUKI MASUDA,*,† AKIHISA MATSUMOTO,‡ TOSHIHIKO TOIDA,‡ TADAO OIKAWA,§KOICHI ITO,# AND HIROAKI NANBA† †Department of Microbial Chemistry, Kobe Pharmaceutical University, Japan, ‡Graduate School of Pharmaceutical Sciences, Chiba University, Japan, §Department of Life Science and Biotechnology, Faculty of Chemistry, Materials and Bioengineering, Kansai University, Japan, and #Science 2 (G12), School of Medical Science, Gold Coast...
read moreSynergistic potentiation of D-fraction with vitamin C as possible alternative approach for cancer therapy Sensuke Konno Department of Urology, New York Medical College, Valhalla, NY, USA Abstract: Maitake D-fraction or PDF is the bioactive extract of maitake mushroom (Grifola frondosa) and its active constituent is the protein-bound polysaccharide (proteoglucan), or more specifically known as Beta-glucan. PDF has been extensively studied and a number of its medicinal potentials/properties have been unveiled and demonstrated. Those include...
read moreMaitake β-glucan enhances therapeutic effect and reduces myelosupression and nephrotoxicity of cisplatin in mice Yuki Masuda a,*, Munechika Inoue a, Ayu Miyata a, Shigeto Mizuno b, Hiroaki Nanba a a Department of Microbial Chemistry, Kobe Pharmaceutical University, Japan b Department of Medical Pharmaceutics, Kobe Pharmaceutical University, Japan Cisplatin is broadly used clinically as an anticancer drug. Despite its significant anticancer activity, cisplatin induced nephrotoxicity and myelosuppression limit its use. MD-Fraction is...
read morePossible disease remission in patient with invasive bladder cancer with D-fraction regimen Srinivas Rajamahanty, Brandon Louie, Cormac O’Neill, Muhammad Choudhury, Sensuke Konno Department of Urology, New York Medical College, Valhalla, New York, USA Abstract: Superficial bladder tumors are the most prevalent form of bladder cancers and transurethral resection is the primary surgical modality for those tumors. However, nearly 65% of patients will have tumor recurrence in five years while about 15% will have progression to muscle invasion....
read moreSynergistic potentiation of interferon activity with maitake mushroom D-fraction on bladder cancer cells Brandon Louie, Srinivas Rajamahanty, John Won, Muhammad Choudhury and Sensuke Konno Department of Urology, New York Medical College, Valhalla, NY, USA To examine whether the combination of interferon (IFN)-α and maitake mushroom D-fraction (PDF), a bioactive mushroom extract, might potentiate the anticancer activity of IFN-α in bladder cancer T24 cells in vitro. IFN-α2B was able to induce a significant ( ≈ 50%) growth...
read moreA phase I/II trial of a polysaccharide extract from Maitake mushroom( Grifola frondosa) in breast cancer patients Gary Deng · Hong Lin · Andrew Seidman · Monica Fornier · Gabriella D’Andrea · Kathleen Wesa · Simon Yeung · Susanna Cunningham-Rundles · Andrew J. Vickers · Barrie Cassileth Abstract Background: Cancer patients commonly use dietary supplements to “boost immune function”. A polysaccharide extract from Grifola frondosa (Maitake extract) showed immunomodulatory effects in preclinical studies and therefore the...
read moreImproving Effects of the Mushroom Yamabushitake (Hericium erinaceus) on Mild Cognitive Impairment: A Double-blind Placebo-controlled Clinical Trial Koichiro Mori1*, Satoshi Inatomi1, Kenzi Ouchi1, Yoshihito Azumi1 and Takashi Tuchida2 1Mushroom Laboratory, Hokuto Corporation, 800-8, Shimokomazawa, Nagano 2Isogo Central and Neurosurgical Hospital, , Yokohama, Japan A double-blind, parallel-group, placebo-controlled trial was performed on 50- to 80-year-old Japanese men and women diagnosed with mild cognitive impairment in order to...
read moreAntiaging Effect of Cordyceps sinensis Extract Deng-Bo Ji’, Jia Chang-Ling Li’, Yu-Hua Wang’, Jiong Zhao’ and Shao-Qing Cai2 ‘Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University, Beijing 2Department of Nature Medicines, School of Pharmaceutical Sciences, Peking University, Beijing This experiment studied the effect of Cordyceps sinensis extract (CSE) on mice aged by n-galactose and castrated rats to analyse its antiaging effect. Water maze and step-down...
read moreComparative study of antioxidant activity and antiproliferative effect of hot water and ethanol extracts from the mushroom Chaga (Inonotus obliquus) Honghai Hu,1 Zhenya Zhang,1 Zhongfang Lei,2•* Yingnan Yang,1 and Norio Sugiural Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba 305-8572, Japan’ Department of Environmental Science and Engineering, Fudan University, Shanghai 200433, China2 The medicinal mushroom Chaga (Inototus obliquus) is a traditional and widely used multi-functional fungus. Hot...
read moreAn extract of the medicinal mushroom Agaricus blazei Murill can protect against allergy Linda K Ellertsen1 and Geir Hetland*2 1Department of Environmental Immunology, Norwegian Institute of Public Health, Oslo, Norway 2Department of Immunology and Transfusion Medicine, Oslo University Hospital, Ulleval, Oslo, Norway Abstract Background: Agaricus blazei Murill (AbM) is an edible Brazilian mushroom that has been used in traditional medicine for a range of diseases. It has been shown to have anti-infection and anti-tumor properties in the...
read more