Immunoceuticals isolated from more than 30 mushroom species have demonstrated anticancer properties in animals, but many fewer have been involved in human cancer research. Of those that are studied in human cancer, all are classified chemically as β-D-glucans (linear polymers of D-glucose with monosaccharides attached) bound to proteins. Collectively they are known as “proteoglycans.” Polysaccharide K (PSK) and polysaccharide peptide (PSP) are the only two proteoglycans that have been systematically investigated in human cancer...
read moreTraditional Chinese medicines (TCM) are growing in popularity. However, are they effective? Cordyceps is not studied as systematically for bioactivity as another TCM, Ganoderma. Cordyceps is fascinating per se, especially because of the pathogenic lifestyle on Lepidopteron insects. The combination of the fungus and dead insect has been used as a TCM for centuries. However, the natural fungus has been harvested to the extent that it is an endangered species. The effectiveness has been attributed to the Chinese philosophical concept of Yin...
read moreCytotoxic and Anti-oxidant Activities of Lanostane-Type Triterpenes Isolated from Poria cocos Liang ZHOU, Yaochun ZHANG, Leslie Adell GAPTER,Hui LING, Rajesh AGARWAL,b and Ka-yun A new lanostane-type triterpene, 29-hydroxypolyporenic acid C (8), was isolated from the dried sclerotia of Poria cocos together with eight other known compounds pachymic acid (I), dehydropachymic acid (2), 3-acetyloxy-16a-hydroxytrametenolic acid (3), polyporenic acid C (4), 3-epi-dehydropachymic acid (5), 3-epi-dehydrotumulosic acid (6), tumulosic acid (7), and...
read moreMeshima (Phellinus linteus) suppresses growth, angiogenesis and invasive behaviour of breast cancer cells through the inhibition of AKT signalling D Sliva1,2‘3, A Jedinak’, J Kawasaki, K Harvey’ and V Slivova’ 1Cancer Research Laboratory, Methodist Research Institute 2Department of Medicine, Indiana University 3lndiana University Simon Cancer Center, School of Medicine, Indiana University The antitumour activity of a medicinal meshima mushroom Phellinus linteus (PL), through the stimulation of immune system or the...
read moreProtein HGFI from the edible mushroom Maitake (Grifola frondosa) is a novel 8 kDa class I hydrophobin that forms rodlets in compressed monolayers Lei Yu,1,2t Baohua Zhang,1 Géza R. Szilvay,2 Ren Sun,1 Janne Jänis,3 Zefang Wang,1 Shuren Feng,1 Haijin Xu,1 Markus B. Linder2 and Mingqiang Qiao1 1College of Life Sciences, Nankai University, 2VTT Biotechnology, Technical Research Centre of Finland 3University of Joensuu, Department of Chemistry Hydrophobins are a group of low-molecular-mass, cysteine-rich proteins that have unusual biophysical...
read moreEvaluation of widely consumed botanicals as immunological adjuvants Govind Ragupathia,∗, K. Simon Yeungb, Ping-Chung Leunge, Mavis Leee, Clara Bik San Laue, Andrew Vickersd, Chandra Hooda, Gary Dengb, Nai-Kong Cheungc, Barrie Cassilethb, Philip Livingstona a Laboratory of Tumor Vaccinology, Melanoma and Sarcoma Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center b Integrative Medicine Memorial Sloan-Kettering Cancer Center c Department of Pediatrics, Memorial Sloan-Kettering Cancer Center d Department of Epidemiology and...
read moreInhibitory Effect of TNF-α Produced by Macrophages Stimulated with Grifola frondosa Extract (ME) on the Growth of Influenza A/Aichi/2/68 Virus in MDCK Cells Nobuko Obi,∗,‡ Katsumi Hayashi,§ Tatsurou Miyahara,† Yutaka Shimada,∗,‡Katsutoshi Terasawa,‡,§ Masataka Watanabe,/ Masahide Takeyama, Ryosuke Obi∗ and Hiroshi Ochiai†,‡ ∗Departments of Oriental Medicine and †Human Science, Faculty ofMedicine ‡21st Century COE Program, University of Toyama §Department of Frontier Japanese Oriental (Kampo) Medicine Graduate...
read moreAntiatherosclerotic effect of the edible mushrooms Pleurotus eryngii (Eringi), Grifola frondosa (Maitake), and Hypsizygus marmoreus (Bunashimeji) in apolipoprotein E?deficient mice Mori K(a,b), Kobayashi C(c), Tomita T(c), Inatomi S(b), Ikeda M(c,d) a) Graduate School of Pharmaceutical Sciences, University of Shizuoka, b)Mushroom laboratory, Hokuto Corporation, c)Graduate School of Health Sciences, University of Shizuoka, d)College of Environment and Disaster Research, Fuji Tokoha University In the present study, we examined the...
read moreA Water-Soluble Extract from Grifola frondosa, Maitake Mushroom, Decreases Lipid Droplets in Brown Adipocyte Tissue Cells Katsuhiko MINAMINO, Yumi NAGASAWA and Masaru OHTSURU Department of Food Science and Nutrition, School of Human Environmental Science, Mukogawa Women’s University, Nishinomiya 663-8558, Japan (Received August 2, 2007) Summary We investigated the effect of a water-soluble extract from Grifola frondosa, the maitake mushroom, on lipid droplets in brown adipocyte tissue (BAT) cells. This water-soluble extract inhibits...
read moreBioactive Substance from Grifola frondosa (Maitake) Mushroom Inhibits CCAAT Enhancer Binding Protein β and δ Expression on C3H10T1/2 B2C1 Adipocyte Cells Katsuhiko MINAMINO, Yuri YANAGA and Masaru OHTSURU* Department of Food Science and Nutrition, School of Human Environmental Science, Mukogawa Women’s University, Nishinomiya 663-8558, Japan Summary Bioactive compound substances from Maitake (Grifola frondosa) inhibited adipocyte differentiation of B2C1 preadipocytes. This compound is not related to MAP kinase (ERK1 and ERK2)...
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