Inhibitory Effect of MD-Fraction on Tumor Metastasis: Involvement of NK Cell Activation and Suppression of Intercellular Adhesion Molecule (ICAM)-1 Expression in Lung Vascular Endothelial Cells Yuki MASUDA,*,a Yukihito MURATA,a Masahiko HAYASHI,b and Hiroaki NANBAa aDepartment of Microbial Chemistry, Kobe Pharmaceutical University and b Department of Pharmacy, Iwaki Meisei University The anti-metastatic activity of MD-Fraction extracted from the maitake mushroom (Grifola frondosa) was examined in an experimental murine model of lung...
read moreSubmerged culture mycelium and broth of Grifola frondosa improve glycemic responses in diabetic rats. Lo HC, Hsu TH, Chen CY. Department of Medical Education and Research, Changhua Christian Hospital, Changhua, Taiwan. Grifola frondosa ( maitake ), an edible fungus with a large fruiting body and overlapping caps, has been demonstrated to be a natural source of health-promoting substances, mainly due to its polysaccharides β-glucan. By using male Wistar rats injected with saline (normal rats) or nicotinamide plus streptozotocin (diabetic...
read moreGrifola frondosa (Maitake Mushroom) Water Extract Inhibits Vascular Endothelial Growth Factor-Induced Angiogenesis Through Inhibition of Reactive Oxygen Species and Extracellular Signal-Regulated Kinase Phosphorylation Jong-Suk Lee,1 Byung Chul Park,1 Yu Jin Ko,1 Mi Kyoung Choi,1 Han Gon Choi,1 Chul Soon Yong,1 Jae-Sung Lee,2 and Jung-Ae Kim1 1College of Pharmacy and 2School of Food Technology and Food Service Industry, Yeungnam University, Gyeongsan, Republic of Korea ABSTRACT Grifola frondosa, a large edible mushroom also known as maitake,...
read morePossible immunotherapeutic potentiation with D-Fraction in prostate cancer cells Paul Pyo, Brandon Louie, Srinivas Rajamahanty, Muhammad Choudhury and Sensuke Konno* Department of Urology, New York Medical College Abstract Background: Prostate cancer remains the most common malignancy among elderly men and the second leading cause of cancer death in the United States. Although several conventional therapies are currently available, they have a low efficacy and the more effective treatment modalities need to be established. Interferons...
read moreEffect of Culinary-Medicinal Lion’s Mane Mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (Aphyllophoromycetideae), on Ethanol-Induced Gastric Ulcers in Rats Mahmood Ameen Abdulla,’,* Suzita Mohd Noor,’ Vikineswary Sabaratnam,2 Noorlidah Abdullah,2 Kah-Hui Wong,2 & Hapipah Mohd Ali3 ‘Department of Molecular Medicine, Faculty of Medicine, 2Institute of Biological Science, Faculty of Science, 3Department of Chemistry, Faculty of Science, University of Malaya ABSTRACT: The cytoprotective effect of Hericium erinaceus...
read moreMedicinal Value of the Caterpillar Fungi Species of the Genus Cordyceps (Fr.) Link (Ascomycetes). A Review John Holliday* & Matt Cleaver ABSTRACT: This review looks in depth at the history and medicinal value of the Cordyceps species, especially C. sinensis. The C. sinensis medicinal species, with a long history of use, has only been found growing from the head of one type of subterranean caterpillar, at high altitudes, in the Qinghai-Tibetan plateau. Because of this highly specific growth environment and restricted geographical...
read moreChaga mushroom (Inonotus obliquus) induces G0/G1 arrest and apoptosis in human hepatoma HepG2 cells Myung-Ja Youn, Jin-Kyung Kim, Seong-Yeol Park, Yunha Kim, Se-Jin Kim, Hong Seob So, Raekil Park, Vestibulocochlear Research Center, Wonkwang University School of Medicine, Jeonbuk, Korea Ki-Young Kim, Ming-Xun Cui,College of Human Environmental Science, Wonkwang University, Jeonbuk, Korea Jin Seok Lee, Kyu Yun Chai, Department of Bionanochemistry, College of Natural Science, Wonkwang University, Jeonbuk, Korea Abstract AIM: To investigate the...
read morePhellinus linteus is a fungus distributed throughout Japan, Korea and China. Boiled watersoluble extracts from P. linteus (PLW) have shown anti-tumor and immunomodulatory properties in experiments done by intraperitoneal treatment, or in in vitro cell cultures. This is the first investigation on how oral administration of PLW influences immune responses. Here, we established immunodeficient mice by mitomycin C (MMC) and then researched how PLW influenced plaque-forming cell (PFC) production and populations of cytokine [interferon-(IFNg-)...
read moreChemical characteristics and immuno-modulating activities of exo-biopolymers produced by Grifola frondosa during submerged fermentation process Byung-Keun Yang, Young-Ah Gu, Yong-Tae Jeong, Hun Jeong, Chi-Hyun Song Abstract The immune-modulating activities and chemical characteristics of exo-biopolymer (EX-GF) produced by a submerged mycelial culture of Maitake (Grifola frondosa) were studied. The EX-GF was fractionated into EX-GF-Fr.1, II, and III by Sephadex G-100 gel chromatography. Anti-complementary activity of EX-GF-Fr. III was highest...
read moreEnhanced insulin-hypoglycemic activity in rats consuming a specific glycoprotein extracted from maitake mushroom Preuss HG, Echard B, Bagchi D, Perricone NV, Zhuang C Department of Physiology, Georgetown University Medical Center Aim: Intraperitoneal glucose tolerance (ipGTT) and insulin challenge (ICT) tests were implemented to evaluate whether a specific glycoprotein extract of maitake mushroom (Grifola frondosa) known as SX-fraction enhances insulin sensitivity in spontaneously hypertensive rats (SHR). Methods: SHR were divided randomly...
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