Stimulating Effects of Grifola frondosa (Maitake) on human osteoblastic cell cultures Saif A, Lindequist U, Wende K Institute of Pharmacy, Ernst-Moritz-Arndt University Greifswald The effect of Grifola frondosa (GF – maitake ) total water extract on two osteoblastic cell cultures (HOS58 and SaOS-2) was investigated to determine if this edible medicinal mushroom has osteoinductive properties. The activity of alkaline phosphate and mineralization were used as indicators for the vitality and maturation of bone cells. The cultivation of...
read moreMushroom-Derived D-fraction as Single Agent for the Treatment of Lymphoma in Dogs P.C. Griessmayr, M. Gauthier, L.G. Barber, and S.M. Cotter Background: D-fraction for Pet is a standardized essence extracted from the mushroom Maitake (Grifola frondosa) that has antitumor activity in tumor-bearing mice. In addition, D-fraction induces apoptosis in human prostate and bladder cancer cells and suppresses the proliferation in vitro of several canine tumor cell lines, such as lymphoma (C1-1), mammary gland (CF33), and connective tissue...
read moreEnhancement of Umbilical Cord Blood Cell Hematopoiesis by Maitake Beta-Glucan Is Mediated by Granulocyte Colony-Stimulating Factor Production Lin H(a,b), Cheung SWY(b), Nesin M(b), Cassileth BR(a), Cunningham-Rundles S(b) a)Integrative Medicine Service, Memorial Sloan-Kettering Cancer Center, New York, New York, b)Host Defenses Program, Department of Pediatrics, Cornell University Weill Medical College, New York, New York Maitake beta-glucan (MBG) is an extract from the fruit body of the Grifola frondosa mushroom that is being widely used to...
read moreSubmerged Production and Characterization of Grifola frondosa Polysaccharides – A New Application to Cosmeceuticals Sang Woo Kim, Hye Jin Hwang, Bum Chun Lee and Jong Won Yun Summary Grifola frondosa (maitake) is traditionally called ‘the king of mushrooms’ and ‘the hen of the woods’. Both the fruiting bodies and the mycelium of maitake have been reported to have antitumor and antiviral activities. Recently, submerged culture processes have been developed, with the intention of providing opportunities for increased...
read moreIsolation, identification and function of a novel anti-HSV-1 protein from Grifola frondosa Gu CQ, Li JW, Chao FH, Jin M, Wang XW, Shen ZQ Institute of Environment and Health, PR China A novel antiviral protein was purified from an extract of Grifola frondosa ( maitake ) fruiting bodies using a procedure that included 40% ammonium sulfate precipitation and DEAE-cellulose ion exchange chromatography, and designated GFAHP. This protein inhibited herpes simplex virus type 1 (HSV-1) replication in vitro with an IC50 value of 4.1 μg/ml and a...
read moreEffect of various natural products on growth of bladder cancer cells: two promising mushroom extracts. Konno S New York Medical College; Department of Urology, Valhalla, NY Despite the availability of several therapeutic options, a safer and more effective modality is urgently needed for treatment of bladder cancer. Specific immunotherapy is effective, but severe side effects limit its clinical use and underscore the need for unconventional therapies using less toxic substances. Many natural substances are touted for their medicinal aspects...
read moreInduction of apoptosis in SGC-7901 cells by polysaccharide-peptide GFPS1b from the cultured mycelia of Grifola frondosa GF9801. Cui FJ(a), Li Y(c), Xu YY(d), Liu ZQ(e), Huang DM(a), Zhang ZC(a), Tao WY(b) a)Institute of Bioengineering, School of Food and Biotechnology, Jiangsu University, b)Laboratory of Biopharmaceutics, School of Biotechnology, Southern Yangtze University, c)Department of Plant Science, North Dakota State University, Fargo, ND,d)Department of Cereal and Food Science, North Dakota State University, Fargo, ND, e)Institute of...
read moreBIOACTIVE COMPOUNDS FROM MUSHROOMS Hirokazu Kawagishi and Cun Zhuang Anti-dementia Compounds We have been engaged in a study to search for nerve growth factor (NGF) synthesis-promoting compounds in medicinal mushrooms, since 1991. We discovered a series of benzyl alcohol derivatives named as hericenones C — H (1 - 6), as well as a series of diterpenoid derivatives named as erinacines A — 1 (7 -15) from Hericium erinaceum, which evidently stimulate NGF production from mouse astroglial...
read moreA Turkey Tails Polysaccharide as an Immunochemotherapy Agent in Cancer Kathy Abascal, B.S., J.D., R.H. (AHG), and Eric Yarnell, N.D., R.H. (AHG) Abstract Trametes versicolor or Coriolus versicolor (turkey tails) is a medicinal mushroom containing a number of protein-bound polysaccharides that have shown strong potential in the treatment of cancer. This discussion examines the use of Polysaccharide Krestin (PSK), a proprietary polysaccharide extracted from T. versicolor, in the treatment of gastric, colorectal, lung, breast, and esophageal...
read morePrevention of radiation-induced damages by aqueous extract of Ganoderma lucidum occurring in southern parts of India Thulasi G. Pillai1, Veena P. Salvi2, Dharmendra Kumar Maurya2,Cherupally Krishnan Krishnan Nair2 and K. K. Janardhanan1,* 1Amala Cancer Research Centre, Thrissur 680 555, India 2Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Mumbai 400 085, India Our previous studies have demonstrated that aqueous extract of Reishi (Ganoderma lucidum) occurring in South India possessed significant antioxidant...
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