Effects of niacin-bound chromium, Maitake mushroom fraction SX and (-)-hydroxycitric acid on the metabolic syndrome in aged diabetic Zucker fatty rats Talpur N, Echard BW, Yasmin T, Bagchi D, Preuss HG. Department of Physiology and Biophysics, Georgetown University Medical Center Previous studies in our laboratories have demonstrated that niacin-bound chromium (NBC), Maitake mushroom and (-)-hydroxycitric acid (HCA-SX) can ameliorate hypertension, dyslipidemias and diabetes mellitus, and therefore may be useful in weight management. In the...
read moreEffect of Maitake (Grifola frondosa) D-Fraction on the activation of NK cells in cancer patients Kodama N, Komuta K, Nanba H. Department of Microbial Chemistry, Kobe Pharmaceutical University Maitake D-Fraction, extracted from maitake mushroom, has been reported to exert its antitumor effect in tumor-bearing mice by enhancing the immune system through activation of macrophages, T cells, and natural killer (NK) cells. In a previous study, the combination of immunotherapy with the maitake D-Fraction and chemotherapy suggested that the D-Fraction...
read moreRelationship between dendritic cells and the D-fraction-induced Th-1 dominant response in BALB/c tumor-bearing mice Harada N, Kodama N, Nanba H. Department of Microbial Chemistry, Kobe Pharmaceutical University Dendritic cells (DCs) are known to not only induce the activation of T cells, but are also associated with the differentiation of T cells. The D-fraction, a β-glucan extracted from maitake (Grifola frondosa) which expresses anti-tumor effects by establishing a helper (Th)-1 dominance in BALB/c mice, enhanced IL-12p70 production by DCs,...
read moreInhibitive effect of cordyceps sinensis on experimental hepatic fibrosis and its possible mechanism Yu-Kan Liu, Wei Shen Department of Gastroenterology, the Second affiliated hospital, Chongqing University of Medical Sciences,China Abstract AIM: To investigate the inhibitive effect and its possible mechanism of Cordyceps Sinensis (CS) on CCl4-plus ethanol-induced hepatic fibrogenesis in experimental rats. METHODS: Rats were randomly allocated into a normal control group, a model control group and a CS group. The latter two groups were...
read moreABSTRACT Objective: The goal of this in vitro study was to test the cytostatic and cytotoxic activities of extracts derived from the polysaccharopeptide (PSP), I’m-Yunity,™ (Integrated Chinese Medicine Holdings Ltd., Kowloon, Hong Kong) prepared from strain Cov-1 of the mushroom Coriolus versicolor. Design: Different volumes of 70% ethanol and water extracts of I’m-Yunity were incubated with cultures of human promyelocytic leukemic HL-60 cells, and compared to nontreated control cells. At various times after treatment, cells were...
read moreIntroduction Despite the medicinal aspects of several mushrooms having been passed down through folklore in the Orient, the scientific study of these mushrooms to explore their biological properties has been initiated only within the past 20 years. A number of researchers have particularly focused their attention on one of these mushrooms called maitake {Grifola frondosa) mushroom. ”Maitake” (pronounced “my-tah-keh”) is an edible, tasty mushroom and literally means “dancing mushroom.”...
read moreThe medicinal mushroom Ganoderma lucidum (G. lucidum) has been used in the Orient for the prevention and treatment of various diseases including cancer. Except for the immune enhancing properties of its polysaccharide constituent, very little is known about the anticancer activity of another major constituent, triterpenes. In this report, we studied the anticancer mechanism of triterpene-enriched extracts from G. lucidum. The triterpeneenriched fraction, WEES-G6, was prepared from mycelia of G. lucidum by sequential hot water...
read moreEffects of a water-soluble extract of maitake mushroom on circulating glucose/insulin concentrations in KK mice Manohar V, Talpur NA, Echard BW, Lieberman S, Preuss HG. Department of Physiology, Georgetown University Medical Center AIM: We examined benefits of a water-soluble extract of maitake mushroom designated as Fraction X (FXM) on the glucose/insulin metabolism of insulin-resistant KK mice, and compared the results of FXM with those of a sulphonylurea, Glipizide. DESIGN: In several acute studies, insulin-resistant KK mice were gavaged...
read moreInteractions of Lipid Metabolism and Intestinal Physiology with Tremella fuciformis Berk Edible Mushroom in Rats Fed a High-Cholesterol Diet with or without Nebacitin HSING-HSIEN CHENG,WEN-CHI HOU, AND MEI-LING LU Male adult Wistar rats were randomly divided into six groups in a 2 x 3 factorial design and fed diets containing different levels of Tremella fuciformis Berk (TFB) dietary fiber (0, 5, or 10%) and 1 g of cholesterol/100 g of diet with or without 0.7% Nebacitin for 4 weeks. TFB contained 6.2% soluble dietary fiber and 57.3% insoluble...
read moreThe Immunomodulating Eifects of Ganoderma lucidum (Curt.: Fr.) P. Karst. (Ling Zhi, Reishi Mushroom) (Aphyllophoromycetideae) Shufeng Zhou and Yihuai Gao ABSTRACT: This review highlights the recent research progress in the study of immunomodulating effects of Ganoderma lucidum (Curt.: Fr.) P. Karst. (reishi mushroom), which belongs to the higher Basidiomycetes. Several major substances with potent immunomodulating action have been isolated. These include polysaccharides (in particular β-D-glucans), proteins, and triterpenoids. The major...
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