REFERENCES
[#2018-10] Chaga Piu, Liu et al. Hypoglycaemic Activities of Two Polysaccharides from Inonotus obliquus
Abstract: In the present study, two polysaccharides (HIOP1-S and HIOP2-S) were isolated and purified from Inonotus obliquus using DEAE-52 cellulose and Sephadex G-100 column chromatography. The structural characterization and in vitro and in vivo hypoglycaemic activities of these molecules were investigated. HPLC analysis HIOP1-S was a heterpolysaccharide with glucose and galactose as the main compontent monosaccharides (50.247%, molar percentages). However, HIOP2-S was a heterpolysaccharide with glucose as the main monosaccharide...
read more[#2018-09] Maitake Zhang, Michael et al. Enhanced Anticancer Effect by Combination of Proteoglucan and Vitamin K3
Bladder cancer is the second common genitourinary malignancy next to prostate cancer in the United States.1 Nearly 82,000 new cases would be diagnosed and ~ 17,000 people may die this year (2018).1 Approximately 75% of all newly diagnosed cases will present nonmuscle invasive bladder cancer (NMIBC) including stage Ta, T1 and carcinoma in situ,2,3 while other 25% are muscle invasive bladder cancers (MIBCs) or metastatic cancers.3 The primary treatment for NMIBC is transurethral resection of bladder tumor (TURBT);4 however, NMIBC...
read more[#2018-08] Cordyceps Jin, Ye et al. Anti-tumor and anti-metastatic roles of cordycepin
Public interest in complementary and alternative medicine has been increased worldwide, due to its wide applications in cancer prevention and treatment. Cordycepin is one of the most common and crucial types of complementary and alternative medicine. Cordycepin (30-deoxyadenosine), a derivative of adenosine, was first isolated from medicine drug Cordyceps militaris. Cordycepin has been widely used as one compound for antitumor, which has been found to exert antiangiogenic, anti-metastatic, and antiproliferative effects, as well as...
read more[#2018-07] Blagodatski, Artem et al. Medicinal mushrooms as an attractive new source of natural compounds for future cancer therapy
Medicinal mushrooms have been used throughout the history of mankind for treatment of various diseases including cancer. Nowadays they have been intensively studied in order to reveal the chemical nature and mechanisms of action of their biomedical capacity. Targeted treatment of cancer, non-harmful for healthy tissues, has become a desired goal in recent decades and compounds of fungal origin provide a vast reservoir of potential innovative drugs. Here, on example of four mushrooms common for use in Asian and Far Eastern folk medicine...
read more[#2018-06] Maitake Mao, Guang-Hua et al. Effect of Grifola frondosa polysaccharide on anti-tumor activity.pdf
GP11 had been reported to have effectively anti-tumor activity by improving the immune function in our previous study. To avoid drawbacks of the 5-Fu, GP11 in combinationwith 5-Fuwas investigated in this study. The results demonstrated that such synergism displayed enhance the anti-tumor activity of 5-Fu. Additionally, a strength effectwas also observed in regulating immune function of GP11 and 5-Fu simultaneous administration, such as enhancing seruminterleukin-2 (IL-2) and tumor necrosis factor-alpha (TNF-α) secretion, and...
read more[#2018-05] Maitake Huang, Jian et al. Grifola Frondosa Polysaccharide improves neutrophils immune function
Grifola frondosa polysaccharide (GFP) is the extract of Grifola frondosa. In this study, 50 male wistar rats were separated into S + C, S + T, LG + T, MG + T and HG + T groups to study the effect of GFP on the immune function of heavy load exercising rats. In S + T group, blood neutrophil number, neutrophil phagocytic index and bactericidal capacity decreased significantly, and adhesion function showed remarkable increase after 8 weeks excessive exercise. Low, medium and high doses of GFP were administered to different groups based on...
read more[#2018-04] Maitake Li, Qian et al. Purification, characterization and immunomodulatory activity of a novel polysaccharide from Grifola frondosa
A novel bioactive polysaccharide, GFP-22, was isolated from the fruit bodies of Grifola frondosa by anion-exchange and gel filtration chromatography. Structure of GFP-22 was investigated using gas chromatography–mass spectrometry (GC–MS), methylation, nuclear magnetic resonance (NMR), high-performance size exclusion chromatography-multi-angle laser light scattering-refractive index detector (HPSEC-MALLS-RI) and atomic force microscopy (AFM) analysis. The backbone of GFP-22 is composed of 1,4-β-D-Glcp, 1,3-β-D-Glcp,...
read more[#2018-03] Maitake Alonso, Eliana Noelia et al. Antitumoral and antimetastatic activity of Maitake D-Fraction in triple-negative breast cancer
Triple-negative breast cancer (TNBC) is associated with poor prognosis, high local recurrence rate and high rate of metastasis compared with other breast cancer subtypes. In addition, TNBC lacks a targeted therapy. This scenario highlights the need for novel compounds with high potential for TNBC treatment. In this regard, natural products are important sources of anticancer drugs. D-Fraction, a proteoglucan extracted from the edible and medicinal mushroom Grifola frondosa (Maitake), is a dietary supplement that has been shown to exert...
read more[#2018-02] Tremella Ruan, Yang et al. Tremella fuciformis Polysaccharides attenuate oxidative stress and inflammation in macrophages through miR-155
Aim - To investigate the function of Tremella fuciformis polysaccharides (TFPS) in LPS-induced inflammation and oxidative stress of macrophages. Methods. RAW264.7 cells were pretreated with TFPS and then stimulated with 0.1 μg/ml LPS. NFκB, Akt, p38MAPK, MCP-1, and SOD-1 were analyzed by Western blotting. Cell viability was measured using MTT assays. Reactive oxygen species (ROS) production, real-time PCR, ELISA, and immunofluorescence staining were performed on RAW264.7 cells that were treated with LPS and/or TFPS to investigate the...
read more[#2018-01] Poria Konno, Sensuke et al. Anticancer effect of Medicinal mushrooms with Prooxidant Activity on Human Bladder Cancer Cells
Oxidative stress (OXS) has been recently considered as one of anticancer strategies by taking advantage of higher vulnerability of cancer cells (than normal cells) to OXS. In fact, the successful outcomes using OXS have been reported in several cancer cases. A medicinal mushroom extract, PE isolated from Poria mushroom, has been shown to have anticancer/antitumor activity, although its anticancer mechanism has not been fully understood but may involve OXS. We investigated if PE might have anticancer effect on human bladder cancer cells through...
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