Cordyceps sinensis is a time-honored tonic food and herbal medicine in China, where recent research has shown that many of its traditional uses may be viewed from the basis of pharmacological activities. The ongoing exploration of C. sinensis in its wild form and cultured, fermented mycelial products derived from it, are reviewed from English and Chinese literature.
read moreTriterpenes from the Spores of Ganoderma lucidum and Their Inhibitory Activity against HIV-I Protease Byung-Sun Min, Norio NAKAMURA, Hirotsugu MIYASHIRO, Ki-Whan Bae, and Masao HATTORI Two new lanostane-type triterpenes, lucidumol A and ganoderic acid β, were isolated from the spores of Reishi ( Ganoderma lucidum ), together with a new natural one and seven that were known. The structures of the new triterpenes were determined as (24S)-24,25-dihydroxylanost-8-ene-3,7-dione and 3β,7β-dihydroxy-11,15-dioxolanosta-8,24(E)-dien-26-oic...
read morePurification and Characterization of a Trehalose Synthase from the Basidiomycete Grifola frondosa ( Maitake ) KOKI SAITO,1 TOSHIYA KASE,1 EIICHI TAKAHASHI,1 EISAKU TAKAHASHI,1 AND SUEHARU HORINOUCHI2* Nishiki Research Laboratories, Kureha Chemical Industry Co., Ltd.,Fukushima, Japan,1 and Department of Biotechnology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Tokyo, Japan2 A trehalose synthase (TSase) that catalyzes the synthesis of trehalose from D-glucose and α-D-glucose 1-phosphate (α-D-glucose 1-P) was...
read moreModification of cellular immune responses in experimental autoimmune hepatitis in mice by maitake (Grifola frondosa) Keiko Kubo and Hiroaki Nanba Department of Microbial Chemistry,KobePharmaceuticalUniversity, ,Japan Immune response to liver-specific lipoprotein (LSP) is involved in the pathogenesis of chronic active hepatitis. Experimental hepatitis could thus be prepared in C57BL/6 mice by injection of liver-specific protein in a syngeneic liver homogenate with Freund’s complete adjuvant. In hepatitic mice treated with maitake...
read moreActivation of by administration with gel-forming (1->3)-β-D-glucan from Grifola frondosa ( Maitake ) Adachi Y, Ohno N, Yadomae T. Laboratory of Immunopharmacology of Microbial Products, Tokyo University of Pharmacy and Life Science The effect of gel-forming (1->3)-β-D-glucan on the immunological activities of murine kupffer cells was examined. A branched type gel-forming (1->3)-β-D-glucan, GRN, was administered intravenously to mice. GRN associating to kupffer cells was detected by an immunohistochemical technique using anti-GRN...
read moreAdjuvant Effect of Grifolan on Antibody Production in Mice Yoshiyuki ADACHI, Yoko SUZUKI, Naohito OHNO, and Toshiro YADOMAE* Laboratory of Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Japan. The effects of grifolan (GRN from maitake ), a gel-forming (1—>6)-branched (1—>3)-β-glucan, on antibody production were examined. Sera from mice that were injected with GRN and trinitrophenyl ovalbumin (TNP-OVA) intraperitoneally showed a significantly increased level of anti-TNP...
read moreThe Scientific Rediscovery of an Ancient Chinese Herbal Medicine: Cordyceps sinensis Part I JIA-SHI ZHU, M.D., Ph.D., GEORGES M. HALPE. M.D., Ph.D.,and KENNETH JONES ABSTRACT This review presents Cordyceps sinensis (Berk.) Sacc., a fungus highly valued in China as a tonic food and herbal medicine. The extant records show the continued use of C. sinensis is now centuries old. The major chemical, pharmacological, and toxicological studies on C. sinensis and the various derived, cultured, fermented mycelia’ products currently in use...
read moreEffects of Lentinus edodes, Grifola frondosa and Pleurotus ostreatus administration on cancer outbreak, and activities of macrophages and lymphocytes in mice treated with a carcinogen, N-butyl-N-butanolnitrosoamine Kurashige S, Akuzawa Y, Endo F. Department of Laboratory Sciences, Gunma University School of Health Sciences ICR mice were treated with a carcinogen, N-butyl-N’-butanolnitrosoamine (BBN), every day for 8 consecutive weeks and the effects of oral administration of edible mushrooms on the induction of urinary bladder carcinoma...
read moreEffect of the Basidiomycete Poria cocos on Experimental Dermatitis and Other Inflammatory Conditions Maria Jesus CUELLAR, Rosa Maria GINER, Maria del Carmen RECIO, Maria Jose JUST, Salvador MANEZ,* and Jose Luis Rios Departament de Farmacologia, Facultat de Farmacia, Universitat de Valencia, Valencia, Spain. The hydroalcoholic extract from Poria cocos was examined for oral and topical anti-inflammatory activities. It proved to be active against carrageenan, arachidonic acid, tetradecanoyl phorbol acetate (TPA) acute edemas, TPA chronic...
read moreAnti-hyperliposis effect of maitake fruit body (Grifola frondosa) Kubo K, Nanba H. Department of Microbial Chemistry, Kobe Pharmaceutical University Experimental rat models (5-week-old Sprague-Dawley rats) with hyperlipemia were prepared by feeding high-cholesterol feed containing sodium cholate and casein as a protein source. Dried maitake (Grifola frondosa) powder was mixed with the basic high-cholesterol feed and the serum lipids were periodically measured. Values of cholesterol, triglyceride and phospholipid in serum of rats in the...
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