REFERENCES
[#1997-05] Sterol Constituents from the Fruit Bodies of Grifola frondosa, T. Ishizuka et al.
Sterol Constituents from the Fruit Bodies of Grifola frondosa Ishizuka, T, Yaoita, Y, Kikuchi, M Tohoku College of Pharmacy Four new sterols, 5α, 6α-epoxy-(22E, 24R)-ergosta-8 (14), 22-diene-3β, 7β-diol (1), (22E, 24R)-ergosta – 8,22-diene-3β,5α,6β,7α-tetrol (2), (22E,24R)-ergosta-7,9(11), 22-triene-3β,5α,6β-triol (3) and 3β,5α,6β-trihydroxy-(22E,24R)-ergost-22-en-7-one (4), have been isolated from the fruit bodies of Grifola frondosa ( maitake ) together with fourteen known ones (5-18), of which two (5 and 6) are reported...
read more[#1997-04] Nitric Oxide Synthesis in Murine Peritoneal Macrophages by Fungal β-Glucans, Tomoe Hashimoto et al.
Nitric Oxide Synthesis in Murine Peritoneal Macrophages by Fungal β-Glucans Tomoe HASHIMOTO, Naohito OHNO, Yoshiyuki ADACHI, and Toshiro YADOMAE* Maitake Laboratory of Immunopharmacology of Microbial Products, Tokyo University of Pharmacy and Life Science, Japan. Fungal β-glucans have abilities to induce NO (nitric oxide) synthesis by macrophages in vivo, and the intensity of NO synthesis significantly varied dependent on the structure of β-glucans. The molecular mechanism of NO synthesis by β-glucans, however, has not been clarified in...
read more[#1997-03] Effect of Maitake D-Fraction on Cancer Prevention, Hiroaki Nanba et al.
Effect of Maitake D-Fraction on Cancer Prevention Nanba, H Kubo, K Department of Microbial Chemistry, Kobe Pharmaceutical University In this paper, the author investigates whether D-fraction is effective against chemically-induced cancer and against metastasis or recrudescence of MM-46 breast cancer. The known carcinogen, methylcholanthrene, was injected into mice. Subsequently, D-fraction or saline was administered. In the D-fraction-treated mice, carcinogenesis occurred in 31% of cases relative to 93% of cases in the control. In a similar...
read more[#1997-02] Maitake D-Fraction: Healing and Preventive Potential for Cancer, Hiroaki Nanba
Maitake D-Fraction: Healing and Preventive Potential for Cancer Nanba, H Kobe Pharmaceutical University, Japan Author has been studying medicinal mushrooms for the last 15 years and has reported that of all mushrooms studied, Maitake Mushroom (Grifola frondosa) has the strongest activity in tumor growth inhibition both in administered orally and intraperitoneally. In this report, Maitake extract D-fraction was investigated to determine its effectiveness not only on the inhibition against tumors already growing, but also on the inhibition of...
read more[#1997-01] Leukocyte activation by (1-3)-β-D glucans, Yoshiyuki Adachi et al.
Leukocyte activation by (1-3)-β-D glucans Yoshiyuki AdachiCA, Mitsuhiro Okazaki, Naohito Ohno and Toshiro Yadomae We studied the activities of several kinds of β-glucans, including sonifilan, grifolan, Sclerotinia sclerotiorum glucan, laminarin and zymosan, on macrophages. Pre-culture of macrophages with inactive β-glucans rendered the cells unresponsive to subsequent stimulation with grifolan, suggesting a specific pathway in the β -glucan structure. The importance of protein C and phosphorylation of mitogen-activated...
read more[#1996-05] Anti Diabetic Mechanism of Maitake (Grifola frondosa), K. Kubo et al.
Anti Diabetic Mechanism of Maitake (Grifola frondosa) Kubo, K, Nanba, H Department of Microbial Chemistry, Kobe Pharmaceutical University Glucose Tolerance Tests were conducted on KK-A mice, model animals of NIDDM (non-insulin dependent diabetes mellitus). The elevated blood glucose levels after 15 minutes and 30 minutes of Maitake-fed group were 0.64 times and 0.76 times those of the control group respectively, indicating inhibition of a significant blood glucose increase. Insulin receptor capability of liver cells then was examined using the...
read more[#1996-04] The effect of maitake mushrooms on liver and serum lipids, K. Kubo
The effect of maitake mushrooms on liver and serum lipids Kubo K, Nanba H. Department of Microbial Chemistry, Kobe Pharmaceutical University OBJECTIVE: To determine the efficacy of maitake mushrooms in inhibiting the elevation of liver and serum lipids in rats. DESIGN: Sprague-Dawley rats with hyperlipidemia were used to measure and compare the values of cholesterol, phospholipids, and triglycerides between cholesterol-fed rats and rats whose diets were fortified with 20% maitake mushroom dried powder. RESULTS: The values in maitake-fed...
read more[#1996-03] Poria Nukaya, Haruo et al. Isolation of Inhibitors of TPA-Induced Mouse Ear Edema from Hoelen
Isolation of Inhibitors of TPA-Induced Mouse Ear Edema from Hoelen, Poria cocos Haruo NUKAYA, Hirokazu YAMASHIRO, Hirotatsu FUKAZAWA, Hitoshi ISHIDA, and Kuniro TSUJI School of Pharmaceutical Sciences, University of Shizuoka, Japan. Several anti-inflammatory substances are known to inhibit the action of tumor promoters in two-stage mouseskin carcinogenesis.”) Since anti-inflammatory activity may play an important role in the mechanism of anti-tumor promotion, we have searched for new anti-inflammatory substances among natural...
read more[#1996-02] Effect of beta-glucans on the nitric oxide synthesis by peritoneal macrophage in mice, N. Ohno et al.
Effect of beta-glucans on the nitric oxide synthesis by peritoneal macrophage in mice Ohno N, Egawa Y, Hashimoto T, Adachi Y, Yadomae T. School of Pharmacy, Tokyo University Pharmacy and Life Science, Japan. Nitric oxide (NO) is an important effector molecule on antimicrobial and antitumor effects of macrophages. (1 -> 3)-β-D-Glucan (β-glucan) is well known to show various immunopharmacological effects such as antimicrobial effect and antitumor effect by activating various points of host defense mechanisms. This paper deals with NO...
read more[#1996-01] Blood clearance of (1->3)-β-D-glucan in MRL lpr/lpr mice, Norihiko Miura et al.
Blood clearance of (1->3)-β-D-glucan in MRL lpr/lpr mice Miura NN, Ohno N, Aketagawa J, Tamura H, Tanaka S, Yadomae T. Laboratory for Immunopharmacology of Microbial Products, Tokyo University of Pharmacy and Life Science (1->3)-β-D-Glucans have a variety of biological and immunopharmacological properties, and they are used clinically as biological response modifiers (BRMs). Clinically, these glucans have often been used for long periods by multiple dosing. During studies on the clearance and metabolism of the glucans in mice, we have...
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