REFERENCES
[#1990-04] An Alkali-Soluble Alpha-D-Glucan from the Fruiting Body of Grifola frondosa, K. Kato et al.
An Alkali-Soluble Alpha-D-Glucan from the Fruiting Body of Grifola frondosa Kato, K, Kawaguchi, M, Kumada, K, Yamauchi, R, Ueno, Y Department of Agricultural Chemistry, Gifu University Previously, we reported studies of the polysaccharides extracted from the fruiting body of the basidiomycete Grifola frondosa ( maitake ) with 10% aqueous zinc choride (designated F4) and 10% aqueous sodium hyroxide (designated F7 and F8). In continuation of this work, we now describe the isolation of an alkali-soluble alpha-D-glucan present in the fruiting...
read more[#1990-03] Antitumor Effect of Orally Administered Extracts from Fruit Body of Grifola frondosa (Maitake), Y. Yamada et al.
Antitumor Effect of Orally Administered Extracts from Fruit Body of Grifola frondosa ( Maitake ) Yamada, Y, Nanba, H, Kuroda, H Laboratory of Microbiology, Kobe Women’s College of Pharmacy We conducted a footpad swelling test to clarify whether a delayed-type hypersensitivity (DTH) reaction against tumor antigen is potentiated by oral administration of D-fraction extracted and purified from fruit body of Grifola frondosa (maitake) with a ratio of β-glucan to protein of 7:3. When the antigen was injected in D-fraction administered...
read more[#1990-02] Change of biological activities of (1-3)-β-D-glucan from Grifola frondosa upon molecular weight reduction by heat treatment, Y. Adachi et al.
Change of biological activities of (1-3)-β-D-glucan from Grifola frondosa upon molecular weight reduction by heat treatment Adachi Y, Ohno N, Ohsawa M, Oikawa S, Yadomae T. Laboratory of Immunopharmacology of Microbial Products, Tokyo College of Pharmacy Changes of biological activities manifested by (1-6)-branched (1-3)-β-D-glucans (from maitake ) of various molecular weights obtained by heat treatment of the corresponding intact β-glucan at 150 degrees C (HD-LE) were examined. The activities assessed in this study were as follows: an...
read more[#1990-01] Macrophage Activation in Vitro by Chemically Cross-Linked (1-3)-β-D-Glucans, Y. Adachi et al.
Macrophage Activation in Vitro by Chemically Cross-Linked (1-3)-β-D-Glucans Yoshiyuki ADACHI,a Naohito °two,’ Masumi OHSAWA, Shozo OEKAWA and Toshiro YADOMAE Tokyo College of Pharmacy, Horinouchi, Hachioji, Tokyo 192-03, Japan and Nippon Beet Sugar Mfg. Co., Ltd., Kyobashi, Chuo-ku, Tokyo 104, Japan. Received September 11, 1989 The chemical cross-linking of soluble (1 -3)-β-D-glucans (from maitake ) having molecular weights of 21000 (CL 3 h) and 6400 (CL 6 h), and laminarin (CL LAMI), which showed negligible biological activity, by...
read more[#1989-04] Antitumor and Immunomodulating Activities of a β-Glucan Obtained from Liquid-Cultured Grifola frondosa, I. Suzuki et al.
Antitumor and Immunomodulating Activities of a β-Glucan Obtained from Liquid-Cultured Grifola frondosa Iwao SUZUKI, Koichi HASHIMOTO, Shozo OIKAWA, Kichiro SATO Masumi OSAWA and Toshiro YADOMAE Tokyo College of Pharmacy, Horinouchi, Hachioji, Tokyo 192-03, Japan and Nippon Beet Sugar Mfg., Co., Ltd., Chuo-ku, Tokyo 104, Japan. The effects of the β-1,3-glucan, LELFD, obtained from liquid-cultured mycelium of Grifola frondosa ( maitake ), on the growth of syngeneic tumors and immune responses in mice were examined. In Meth A or...
read more[#1989-03] Modification of Immunostimulating Activities of Grifolan by the Treatment with (1—.3)-p-D-Glucanase, I. Nono
Modification of Immunostimulating Activities of Grifolan by the Treatment with (1—.3)-p-D-Glucanase Isao NONO, Naohito OHNO,* Masumi OHSAWA, Shozo OIKAWA,** and Toshiro YADOMAE* Tokyo College of Pharmacy, * Horinouchi, Hachioji, Tokyo, 192-03, Japan and Nippon Beet Sugar Mfg., Co., Ltd., ** Chuo-ku, Tokyo, 104, Japan We have developed a method to control the effective time period of (1->3)-β-D-glucan in vivo by using (1->3)-β-D-glucanase and found that grifolan LE (GRN), from maitake ) , a (1->3)-β-D-glucan, administered...
read more[#1989-02] Modulation of Antitumor Activity of Grifolan by Subsequent Administration of (1–>3)-β-D-Glucanase in Vivo, I. Nono et al.
Modulation of Antitumor Activity of Grifolan by Subsequent Administration of (1–>3)-β-D-Glucanase in Vivo Isao NONO, Naohito OHNO,* Masumi OHSAWA, Shozo OIKAWA and Toshiro YADOMAE Laboratory of Immunopharmacology of Microbial Products, Tokyo College of Pharmacy, Horinouchi,Hachioji, Tokyo, 192-03, Japan and Nippon Beet Sugar Mfg., Co., Ltd., Chuo-ku, Tokyo, 104, Japan The initiation process of effector mechanism of the antitumor activity of (1–>3)-β-D-glucans has been examined in detail by applying treatment of mice...
read more[#1989-01] Maitake – Physiochemical properties and antitumor activities of chemically modified derivatives of antitumor glucan “grifolan LE” from Grifola frondosa, Y. Adachi et al.
Maitake - Physiochemical properties and antitumor activities of chemically modified derivatives of antitumor glucan “grifolan LE” from Grifola frondosa Adachi Y, Ohno N, Ohsawa M, Sato K, Oikawa S, Yadomae T. Laboratory of Immunopharmacology of Microbial Products, Tokyo College of Pharmacy Antitumor glucan, grifolan LE (GRN LE), from Grifola frondosa ( maitake ) was chemically modified to examine the structure-function relationship of the products. Modification by periodate, borohydride and acid hydrolysis of side chains of GRN...
read more[#1988-03] Distribution of Grifolan NMF-5N (I/B), a Chemically Modified Antitumor β- Glucan in Mice, T. Takeyama et al.
Distribution of Grifolan NMF-5N (I/B), a Chemically Modified Antitumor β- Glucan in Mice Takahiro TAKEYAMA, Iwao SUZUKI, Naohito OHNO,* Shozo OIKAWA, Kichiro SATO, Masumi OHSAWA,** and Toshiro YADOMAE* Tokyo College of Pharmacy, * Horinouchi, Hachioji, Tokyo, 192-03, Japan and Nippon Beet Sugar Mfg., Co., Ltd., ** Chuo-ku, Tokyo, 104, Japan The distribution of a 3H-labeled chemically modified antitumor β-glucan, grifolan ( from maitake ) NMF-5N (I/B), in various tissues after an injection into mice was examined in order to obtain...
read more[#1988-02] Antitumor Activity Exhibited by Orally Administered Extract from Fruit Body of Grifola frondosa (Maitake), I. Hishida et al.
Antitumor Activity Exhibited by Orally Administered Extract from Fruit Body of Grifola frondosa (Maitake) Hishida, I, Nanba, H, Kuroda, H Laboratory of Microbiology, Kobe Women’s College of Pharmacy, Japan The acid-insoluble, alkali-soluble, hot water-extractable polymer (a polysaccharide containing approximately 30% of protein; D-fraction) obtained from the fruit bodies of Grifola frondosa ( maitake ) exhibited antitumor activities against allogenic and syngeneic tumors on oral administration to mice. Winn assay conducted to examine the...
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