REFERENCES
[#1986-07] Characterization of the Antitumor Glucan Obtained from Liquid-Cultured Grifola frondosa, N. Ohno et al.
Characterization of the Antitumor Glucan Obtained from Liquid-Cultured Grifola frondosa Ohno, N (a), Adachi, Y (a), Suzuki, I (a), Sato, K (b), Oikawa, S (b), Yadomae, T(a) a) Tokyo College of Pharmacy, b) Nippon Beet Sugar Mfg. Co. Ltd. Chemical characterization of the extracts, and purification and structural characterization of an antitumor glucan obtained from liquid-cultured mycelium of Grifola frondosa ( maitake ) are described in this paper. The mycelium (13 g dry weight/l culture) was extracted successively with hot water (LMHW, 14.9...
read more[#1986-06] Two Different Conformations of Antitumor Glucans Obtained from Grifola frondosa, Naohito Ohno et al.
Two Different Conformations of Antitumor Glucans Obtained from Grifola frondosa Ohno, N (a), Adachi, A (a), Suzuki, A (a), Oikawa, S (b), Sato, K (b), Suzuki, Y (b), Ohsawa, M (b), Yadomae, T (a) a) Tokyo College of Pharmacy, b) Nippon Beet Sugar Mfg. Co. Ltd. Several antitumor glucan fractions obtained by various extraction procedures from Grifola frondosa ( maitake ) were compared by solution and solid (cross polarization, magic angle spinning (CP/MAS)) carbon-13 nuclear magnetic resonance (13C-NMR) spectroscopy. The fractions prepared...
read more[#1986-05] Antitumor activity of a β-1,3-glucan obtained from liquid cultured mycelium of Grifola frondosa, Naohito Ohno et al.
Antitumor activity of a β-1,3-glucan obtained from liquid cultured mycelium of Grifola frondosa Ohno N, Adachi Y, Suzuki I, Oikawa S, Sato K, Ohsawa M, Yadomae T. Tokyo College of Pharmacy The antitumor activity of a branched β-1,3-glucan “grifolan LE” purified from liquid cultures of Grifola frondosa ( maitake ) (Ohno et al. Chem. Pharm. Bull., 34, 1709-1715, 1986) was examined on an allogeneic murine tumor system. By intraperitoneal (i.p.) administration (100-200 μg/mouse/d X 5) at days 1 to 9 from the tumor transplantation,...
read more[#1986-04] Effect of Activation or Blockade of the Phagocytic System on the Antitumor Activity of Grifolan, Naohito Ohno et al.
Effect of Activation or Blockade of the Phagocytic System on the Antitumor Activity of Grifolan NAOHITO OHNO,a MAMI HAYASHI,a IWAO SUZUKI,a SHOZO OIKAWA,b KICHIRO SATO,b YOSHIYUKI Suzuiu,b and TOSHIRO YADOMAE*‘ a Tokyo College of Pharmacy,a and Nippon Beet Sugar Mfg., Co., Ltd.,b The effect of activation or blockade of the phagocytic system on the antitumor activity of grifolan from Maitake was investigated. The activity of grifolan was abrogated by treatment of mice with a blocker of the phagocytic system, i.e., carrageenan,...
read more[#1986-03] Fractionation of Acidic Antitumor β-Glucan of Grifola frondosa by Anion-Exchange Chromatography Using Urea Solutions of Low and High Ionic Strengths, Naohito Ohno et al.
Fractionation of Acidic Antitumor β-Glucan of Grifola frondosa by Anion-Exchange Chromatography Using Urea Solutions of Low and High Ionic Strengths NAOHITO OHNO,a KAZUYOSHI IINO,a SHOZO OEKAWA,b KICHIRO SATO,b MASUMI OHSAWA,b and TOSHIRO YADOMAE*‘ a Tokyo College of Pharmacy,’ Horinouchi, Hachioji, Tokyo 192-03, Japan and Nippon Beet Sugar Mfg. Co., Ltd.,’ Kyobashi, Chuo-ku, Tokyo 104, Japan The antitumor β-glucan from the fruit body of Grifola frondosa ( Maitake ) was resolved by DEAE Sephadex chromatography into...
read more[#1986-02] Effect of Glucans on the Antitumor Activity of Grifolan, Naohito Ohno et al.
Chem. Pharm. Bull. 1986; 34(5): 2149-54. Effect of Glucans on the Antitumor Activity of Grifolan Ohno, N(a), Hayashi, M (a), Iino, K (a), Suzuki, I (a), Oikawa, S (b), Sato, K (b), Suzuki, Y (b), Yadomae , T (a) a)Tokyo College of Pharmacy, b) Nippon Beet Sugar Mfg. Co. Ltd. The effects of antitumor active [β-1,3-glucan(grifolan)] and inactive [β-1,6-(islandican), α-1,4-(starch)]glucans in mice were compared. β-1,6-Glucan enhanced the antitumor activity of grifolan, whereas α-1,4-glucan showed a suppressive effect on the antitumor...
read more[#1986-01] Fractionation and Characterization of Antitumor Polysaccharides from Maitake, Grifola frondosa, T. Mizuno et al.
Fractionation and Characterization of Antitumor Polysaccharides from Maitake, Grifola frondosa Mizuno, T, Ohsawa, K, Hagiwara, N, Kuboyama, R Dept. of Agricultural Chemistry, Faculty of Agriculture, Shizuoka University Three groups of polysaccharides from the edible mushroom, “Maitake”, the cultured fruiting body of Grifola frondosa, were extracted with hot water, 3% NH4-oxalate (100o C), and 5% sodium hydroxide solution (30o C ) in this order. The three fractions, FI, FII, and FIII, were divided into several sub-fractions using...
read more[#1985-07] Structural Characterization of a Neutral Antitumor Beta-D-Glucan Extracted with Hot Sodium Hydroxide from Cultured Fruit Bodies of Grifola frondosa, K. Iino et al.
Structural Characterization of a Neutral Antitumor Beta-D-Glucan Extracted with Hot Sodium Hydroxide from Cultured Fruit Bodies of Grifola frondosa Iino, K(a), Ohno, N(a), Suzuki, I(a), Miyazaki, T(a), Yadomae, T(a), Oikawa, S(b), Sata, K(b) a) Laboratory of Immunopharmacology of Microbial Proudcts, Tokyo College of Pharmacy, b) Nippon Beet Sugar Mfg. Co. Ltd. The structural characterization of an antitumor beta-D-glucan (grifolan-7N) obtained from the hot sodium hydroxide extract of Grifola frondosa ( maitake ), is described. Grifolan-7N,...
read more[#1985-06] Reishi Kohda, Hiroshi et al. The Biologically Active Constituents of Ganoderma lucidum (Fr.) Karst. Histamine Release Inhibitory Triterpenes
The Biologically Active Constituents of Ganoderma lucidum (FR..) KARST. Histamine Release-Inhibitory Triterpenes HIROSHI KOHDA,a WAKAKO TOKUMOTO,a KIYOE SAKAMOTO,a MICHIKO FUJII,a YUKO HIRAI,a KAZUO YAMASAKI,*’ a YASUO KOMODA,bHIDEO NAKAMURA,` SHIGEMASA ISHIHARA`and MASARU UCHIDA` Institute of Pharmaceutical Sciences, School of Medicine, Hiroshima University,’1-2-3, Kaszoni, Minami-ku, Hiroshima 734, Japan, Institute for Medical andDental Engineering, Tokyo Medical and Dental University,’ 2-3-10,Surugadai, Kanda, Chiyoda-ku,...
read more[#1985-05] Effect of a polysaccharide fraction from Grifola frondosa on immune response in mice, I. Suzuki et al.
Effect of a polysaccharide fraction from Grifola frondosa on immune response in mice Suzuki I, Itani T, Ohno N, Oikawa S, Sato K, Miyazaki T, Yadomae T. Tokyo College of Pharmacy The biological and immunomodulating activities of polysaccharide fraction (GF-1), an antitumor poysaccharide fraction from cultured fruiting bodies of Grifola frondosa ( maitake ), was examined in mice. GF-1 showed no cytocidal effect on culturing tumor cells. However, GF-1 induced resistance against Sarcoma 180 in ICR mice which had completely regressed from the...
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