REFERENCES
[#2018-03] Maitake Alonso, Eliana Noelia et al. Antitumoral and antimetastatic activity of Maitake D-Fraction in triple-negative breast cancer
Triple-negative breast cancer (TNBC) is associated with poor prognosis, high local recurrence rate and high rate of metastasis compared with other breast cancer subtypes. In addition, TNBC lacks a targeted therapy. This scenario highlights the need for novel compounds with high potential for TNBC treatment. In this regard, natural products are important sources of anticancer drugs. D-Fraction, a proteoglucan extracted from the edible and medicinal mushroom Grifola frondosa (Maitake), is a dietary supplement that has been shown to exert...
read more[#2018-02] Tremella Ruan, Yang et al. Tremella fuciformis Polysaccharides attenuate oxidative stress and inflammation in macrophages through miR-155
Aim - To investigate the function of Tremella fuciformis polysaccharides (TFPS) in LPS-induced inflammation and oxidative stress of macrophages. Methods. RAW264.7 cells were pretreated with TFPS and then stimulated with 0.1 μg/ml LPS. NFκB, Akt, p38MAPK, MCP-1, and SOD-1 were analyzed by Western blotting. Cell viability was measured using MTT assays. Reactive oxygen species (ROS) production, real-time PCR, ELISA, and immunofluorescence staining were performed on RAW264.7 cells that were treated with LPS and/or TFPS to investigate the...
read more[#2018-01] Poria Konno, Sensuke et al. Anticancer effect of Medicinal mushrooms with Prooxidant Activity on Human Bladder Cancer Cells
Oxidative stress (OXS) has been recently considered as one of anticancer strategies by taking advantage of higher vulnerability of cancer cells (than normal cells) to OXS. In fact, the successful outcomes using OXS have been reported in several cancer cases. A medicinal mushroom extract, PE isolated from Poria mushroom, has been shown to have anticancer/antitumor activity, although its anticancer mechanism has not been fully understood but may involve OXS. We investigated if PE might have anticancer effect on human bladder cancer cells through...
read more[#2017-12] Cordyceps Hwang, In-Hu et al. Cordycepin promotes apoptosis in renal carcinoma
Cellular FLICE inhibitory protein (c-FLIP) is a key anti-apoptotic regulator that associates with the signaling complex downstream of NF-κB, negatively interfering with apoptotic signaling. The role of c-FLIP downregulation by negative regulation of NF-κB signaling during apoptosis is poorly understood. Here, we demonstrate that NF-κB-mediated c-FLIPL negatively regulates the JNK signaling pathway, and that cordycepin treatment of human renal cancer cells leads to apoptosis induction through c-FLIPL inhibition. TNF-α-induced...
read more[#2017-11] Cordyceps Panicker, Sangeetha et al. Cordyceps the Fungal Gold
Cordyceps is an entomophagous medicinal mushroom that commands a price close to that of Gold or even more, it is believed that the price of this fungus reached USD $20,000 to 40,000 per kg in the international market. Cordyceps spp is mainly endemic to the Tibetian plateau including the adjoining high altitude areas of the central and East Himalayas that includes Nepal, Bhutan and India’s Uttaranchal, Sikkim, Himachal and Arunachal Pradesh. However certain species like Cordyceps militaris is said to be distributed worldwide from 0 to...
read more[#2017-10] Lion’s Mane Spelman, Kevin et al. Neurological Activity of Lions Mane
Hericium erinaceus, most commonly known as lion’s mane, is an edible fungus, with a long history of use in Traditional Chinese Medicine. The mushroom is abundant in bioactive compounds including β-glucan polysaccharides; hericenones and erinacine terpenoids; isoindolinones; sterols; and myconutrients, which potentially have neuroprotective and neuroregenerative properties. Because of its anti-inflammatory properties and promotion of nerve growth factor gene expression and neurite (axon or dendrite) outgrowth, H. erinaceus mycelium...
read more[#2017-09] Meshima Arcella, Antonietta et al. Effects of hispolon on glioblastoma cell growth
Hispolon is a polyphenolic compound isolated from Phellinus linteus which exhibits antitumor activity. Here, we explored the effects of hispolon on human glioblastoma cells U87MG. Cell viability was examined by MTT assay. Growth was investigated by incubating cells with various concentrations of hispolon (25 and 50 mM) for 24, 48 or 72 h and daily cell count. Cell cycle and apoptosis assay were assessed by flow cytometry. Hispolon decreased cell viability in a dose- and timedependent manner. The cell cycle distribution showed that...
read more[#2017-08] Reishi Muhammad, Aslan et al. Antidepressant like activity of ethanol extract of ganoderma lucidum reishi in mice
Ganoderma lucidum, known as “Lingzhi” in China, is one among greatly regarded fungi around the world. In old Chinese encyclopedias of medical “Shen Nong’s Ben Cao Jing” and “Ben Cao Gang Mu”, it is rated as extraordinarily precious fungus. In this study, antidepressant activity of ethanol extract of Ganoderma lucidum has been assessed. The extract was given orally by gavage at the dose of 20 mg/kg, 75 mg/kg, and 130 mg/kg body weight. Fluoxetine (20 mg/kg p.o.) was used as the standard drug. The results of our study show that...
read more[#2017-07] Reishi Cao, Fang-Ruie et al. Plasma and brain pharmacokinetics of ganodric acid A in rats determined by a developed UFLC-MS MS method
Ganoderic acid A (GAA), an active triterpenoid of the traditional Chinese herbal medicine Lingzhi, hasbeen reported to exhibit antinociceptive, antioxidative, and anti-cancer activities. The present study aimsto establish a sensitive and rapid UPLC–MS/MS method for studying the plasma and brain pharmacoki-netics of GAA in rats. The analytes were separated on a C18 column eluted with a gradient mobile phaseconsisting of acetonitrile and 0.1% aqueous formic acid at 0.3 mL/min. The eluate was monitored by amass detector using an MRM (m/z,...
read more[#2017-06] Reishi, Vela Gurovic, Maria Soledad et al. DNA damaging potential of Ganoderma lucidum extracts
Ganoderma lucidum (Lingzhi or Reishi) is a medicinal mushroom historically used in Asian countries to treat a wide variety of diseases and prolong life. In the last years, G. lucidum has been internationally recognized as an effective adjuvant in cancer treatment. Among active components, the most recent research indicates that polysaccharides modulate the immune response favoring the recovery from toxicity of chemo and radiotherapy while triterpenes are cytotoxic to tumoral cells mainly by altering gene expression. Beyond this body of...
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