REFERENCES
[#2017-12] Cordyceps Hwang, In-Hu et al. Cordycepin promotes apoptosis in renal carcinoma
Cellular FLICE inhibitory protein (c-FLIP) is a key anti-apoptotic regulator that associates with the signaling complex downstream of NF-κB, negatively interfering with apoptotic signaling. The role of c-FLIP downregulation by negative regulation of NF-κB signaling during apoptosis is poorly understood. Here, we demonstrate that NF-κB-mediated c-FLIPL negatively regulates the JNK signaling pathway, and that cordycepin treatment of human renal cancer cells leads to apoptosis induction through c-FLIPL inhibition. TNF-α-induced...
read more[#2017-11] Cordyceps Panicker, Sangeetha et al. Cordyceps the Fungal Gold
Cordyceps is an entomophagous medicinal mushroom that commands a price close to that of Gold or even more, it is believed that the price of this fungus reached USD $20,000 to 40,000 per kg in the international market. Cordyceps spp is mainly endemic to the Tibetian plateau including the adjoining high altitude areas of the central and East Himalayas that includes Nepal, Bhutan and India’s Uttaranchal, Sikkim, Himachal and Arunachal Pradesh. However certain species like Cordyceps militaris is said to be distributed worldwide from 0 to...
read more[#2017-10] Lion’s Mane Spelman, Kevin et al. Neurological Activity of Lions Mane
Hericium erinaceus, most commonly known as lion’s mane, is an edible fungus, with a long history of use in Traditional Chinese Medicine. The mushroom is abundant in bioactive compounds including β-glucan polysaccharides; hericenones and erinacine terpenoids; isoindolinones; sterols; and myconutrients, which potentially have neuroprotective and neuroregenerative properties. Because of its anti-inflammatory properties and promotion of nerve growth factor gene expression and neurite (axon or dendrite) outgrowth, H. erinaceus mycelium...
read more[#2017-09] Meshima Arcella, Antonietta et al. Effects of hispolon on glioblastoma cell growth
Hispolon is a polyphenolic compound isolated from Phellinus linteus which exhibits antitumor activity. Here, we explored the effects of hispolon on human glioblastoma cells U87MG. Cell viability was examined by MTT assay. Growth was investigated by incubating cells with various concentrations of hispolon (25 and 50 mM) for 24, 48 or 72 h and daily cell count. Cell cycle and apoptosis assay were assessed by flow cytometry. Hispolon decreased cell viability in a dose- and timedependent manner. The cell cycle distribution showed that...
read more[#2017-08] Reishi Muhammad, Aslan et al. Antidepressant like activity of ethanol extract of ganoderma lucidum reishi in mice
Ganoderma lucidum, known as “Lingzhi” in China, is one among greatly regarded fungi around the world. In old Chinese encyclopedias of medical “Shen Nong’s Ben Cao Jing” and “Ben Cao Gang Mu”, it is rated as extraordinarily precious fungus. In this study, antidepressant activity of ethanol extract of Ganoderma lucidum has been assessed. The extract was given orally by gavage at the dose of 20 mg/kg, 75 mg/kg, and 130 mg/kg body weight. Fluoxetine (20 mg/kg p.o.) was used as the standard drug. The results of our study show that...
read more[#2017-07] Reishi Cao, Fang-Ruie et al. Plasma and brain pharmacokinetics of ganodric acid A in rats determined by a developed UFLC-MS MS method
Ganoderic acid A (GAA), an active triterpenoid of the traditional Chinese herbal medicine Lingzhi, hasbeen reported to exhibit antinociceptive, antioxidative, and anti-cancer activities. The present study aimsto establish a sensitive and rapid UPLC–MS/MS method for studying the plasma and brain pharmacoki-netics of GAA in rats. The analytes were separated on a C18 column eluted with a gradient mobile phaseconsisting of acetonitrile and 0.1% aqueous formic acid at 0.3 mL/min. The eluate was monitored by amass detector using an MRM (m/z,...
read more[#2017-06] Reishi, Vela Gurovic, Maria Soledad et al. DNA damaging potential of Ganoderma lucidum extracts
Ganoderma lucidum (Lingzhi or Reishi) is a medicinal mushroom historically used in Asian countries to treat a wide variety of diseases and prolong life. In the last years, G. lucidum has been internationally recognized as an effective adjuvant in cancer treatment. Among active components, the most recent research indicates that polysaccharides modulate the immune response favoring the recovery from toxicity of chemo and radiotherapy while triterpenes are cytotoxic to tumoral cells mainly by altering gene expression. Beyond this body of...
read more[#2017-05] Maitake Zhang, Yizhi et al. Grifola frondosa polysaccharides induce breast cancer cell apoptosis via the mitochondrial-dependent apoptotic pathway
Grifola frondosa, a type of food and medical fungus, has been shown to exhibit various pharmacological activities, including anticancer effects. As the most typical cancer diagnosed among female patients, breast cancer remains a huge concern threatening human health globally. In the present study, the anti-breast cancer effects of Grifola frondosa polysaccharides (GFPs) and the underlying mechanisms were investigated in MCF-7 and MDA-MB-231 cells, as well as in nude mice bearing MCF-7 tumor xenografts. GFPs exerted cytotoxic effects on the...
read more[#2017-04] Royal Agaricus Gobi, Veerapan Venkatesh et al. Agaricus blazei extract abrogates rotenone-induced dopamine depletion
Neuroinflammation and oxidative damage are the two main malfactors that play an important role in the pathogenesis of experimental and clinical Parkinson’s disease (PD). The current study was aimed to study the possible anti-oxidant and anti-inflammatory effects of the methanolic extract of Agaricus blazei (A. blazei) against rotenone-induced PD in mice. Male Albino mice were randomized and divided into the following groups: control, treated with rotenone (1 mg/kg/day), co-treated with rotenone and A. blazei (50, 100, and 200 mg/kg...
read more[#2017-03] Maitake Alonso, Eliana Noelia et al. Antitumoral Effects of D Fraction from Grifola Frondosa Maitake Mushroom in Breast Cancer (1)
D-Fraction is protein-bound b-1,6 and b-1,3 glucans (proteoglucan) extracted from the edible and medicinal mushroom Grifola frondosa (Maitake). The antitumoral effect of D-Fraction has long been exclusively attributed to their immunostimulatory capacity. However, in recent years increasing evidence showed that D-Fraction directly affects the viability of canine and human tumor cells, independent of the immune system. Previously, we have reported that D-Fraction modulates the expression of genes associated with cell proliferation, cell...
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