REFERENCES
[#2017-05] Maitake Zhang, Yizhi et al. Grifola frondosa polysaccharides induce breast cancer cell apoptosis via the mitochondrial-dependent apoptotic pathway
Grifola frondosa, a type of food and medical fungus, has been shown to exhibit various pharmacological activities, including anticancer effects. As the most typical cancer diagnosed among female patients, breast cancer remains a huge concern threatening human health globally. In the present study, the anti-breast cancer effects of Grifola frondosa polysaccharides (GFPs) and the underlying mechanisms were investigated in MCF-7 and MDA-MB-231 cells, as well as in nude mice bearing MCF-7 tumor xenografts. GFPs exerted cytotoxic effects on the...
read more[#2017-04] Royal Agaricus Gobi, Veerapan Venkatesh et al. Agaricus blazei extract abrogates rotenone-induced dopamine depletion
Neuroinflammation and oxidative damage are the two main malfactors that play an important role in the pathogenesis of experimental and clinical Parkinson’s disease (PD). The current study was aimed to study the possible anti-oxidant and anti-inflammatory effects of the methanolic extract of Agaricus blazei (A. blazei) against rotenone-induced PD in mice. Male Albino mice were randomized and divided into the following groups: control, treated with rotenone (1 mg/kg/day), co-treated with rotenone and A. blazei (50, 100, and 200 mg/kg...
read more[#2017-03] Maitake Alonso, Eliana Noelia et al. Antitumoral Effects of D Fraction from Grifola Frondosa Maitake Mushroom in Breast Cancer (1)
D-Fraction is protein-bound b-1,6 and b-1,3 glucans (proteoglucan) extracted from the edible and medicinal mushroom Grifola frondosa (Maitake). The antitumoral effect of D-Fraction has long been exclusively attributed to their immunostimulatory capacity. However, in recent years increasing evidence showed that D-Fraction directly affects the viability of canine and human tumor cells, independent of the immune system. Previously, we have reported that D-Fraction modulates the expression of genes associated with cell proliferation, cell...
read more[#2017-02] Maitake He, Xirui et al. Polysaccharides in Grifola frondosa mushroom and their health promoting properties, A review
Grifola frondosa is a widely consumed edible and medicinal fungus, Ancient books record that it can boost qi and fortify the spleen, moisten the lung and protect the liver. Modern people mainly use it to assist in the treatment of diabetes mellitus and various cancers. Over the past three decades, G. frondosa polysaccharides were shown to possess various promising bioactivities, mainly including anti-tumor and immunomodulation, anti-oxidation, anti-hyperglycemia, and meanwhile can effectively act on the skin and hematopoietic stem cells. The...
read more[#2017-01] Lion’s Mane Phan, Chia-Wei et al Edible and Medicinal Mushrooms – Emerging Brain Food for the Mitigation of Neurodegenerative Diseases
There is an exponential increase in dementia in old age at a global level because of increasing life expectancy. The prevalence of neurodegenerative diseases such as dementia and Alzheimer’s disease (AD) will continue to rise steadily, and is expected to reach 42 million cases worldwide in 2020. Despite the advancement of medication, the management of these diseases remains largely ineffective. Therefore, it is vital to explore novel nature-based nutraceuticals to mitigate AD and other age-related neurodegenerative disorders. Mushrooms...
read more[#2016-12] Lion’s Mane Sokol, Slawomir et al. Biology, cultivation, and medicinal functions of the mushroom Hericium erinaceus
Hericium erinaceum (Bull.: Fr.) Pers. is an edible fungus of great significance in medicine. It is rarely found in Europe, in contrast, it is common in Japan and North America. Its fruitbodies have been well-known for hundreds of years in traditional Chinese medicine and cuisine. A cradle of H. erinaceum cultivation is Asia. In Eastern Europe is rare in natural habitats, but can be successfully cultivated. Both fruitbodies and mycelia are rich in active, health promoting substances. Tests of substances extracted from this mushroom...
read more[#2016-11] Cordyceps Wang, Ningqun et al. Herbal Medicine Cordyceps sinensis improves health related qualtiy of life in moderate to severe asthma
Moderate-to-severe asthma has a substantial impact on the health-related quality of life (HR-QOL) of the patients. Cordyceps sinensis is a traditional Chinese medicine that is evaluated clinically for the treatment of many diseases, such as chronic allograft nephropathy, diabetic kidney disease, and lung fibrosis. In order to investigate the effects of Cordyceps sinensis on patients with moderate-to-severe persistent asthma, 120 subjects were randomized to receive Corbin capsule containing Cordyceps sinensis for 3 months (treatment group,
read more[#2016-10] Maitake Erjavec, Igor et al. Mushroom Extracts Decrease Bone Resorption and Improve Bone Formation
ABSTRACT: Mushroom extracts have shown promising effects in the treatment of cancer and various chronic diseases. Osteoporosis is considered one of the most widespread chronic diseases, for which currently available therapies show mixed results. In this research we investigated the in vitro effects of water extracts of the culinary-medicinal mushrooms Trametes versicolor, Grifola frondosa, Lentinus edodes, and Pleurotus ostreatus on a MC3T3-E1 mouse osteoblast-like cell line, primary rat osteoblasts, and primary rat osteoclasts. In an...
read more[#2016-09] Meshima Konno, Sensuke et al. Alternative Therapeutic Approach to Urothelial Cell Carcinoma with Medicinal Mushroom Extracts
Abstract Severe side effects from chemotherapy or immunotherapy often limit their clinical utility in urothelial cell carcinoma of the bladder. To explore alternative therapies, we were particularly interested in one of medicinal mushrooms called Phellinus linteus (PL) with antitumor/anticancer activity. We investigated possible anticancer effects of three distinct extracts or fractions of PL using an urothelial cell carcinoma (UCC) model in vitro. Those fractions included PL-I (crude extract), PL-II (water-extracted), and PL-III...
read more[#2016-08] Maitake Bao, Hongkun et al. Grifola frondosa GF produces significant antidepressant effects involving AMPA receptor activation in mice
In this paper, we investigated the antidepressant effects of the medical mushroom GF. We found that (1) GF demonstrated antidepressant effects in the TST and FST after 1-day or 5-day treatments; (2) GF led to no hyperactive effects in the OFT; (3) The antidepressant effects of GF were stronger compared to the other medical mushroom PO; (4) AMPA receptor-specific antagonist GYKI 52466 was able to block the antidepressant effects of GF, suggesting that AMPA receptors are involved in the antidepressant effects of GF.
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