Tremella fuciformis (family Tremellaceae, ordem Tremellales, class Basidiomycetes) is probably one of the most beautiful fungi growing in subtropical and tropical areas, or even temperate zones. It was first found in Brazil but has developed to an artificially cultivated species in Taiwan, China and some other countries in Asia (Urben, 2006, 2010). It is clearly associated with Ascomycetes in the field, especially Hypoxylon spp., however, unlike other Tremella mycoparasites in basidiocarps of Basidiomycetes, the real host-relationship of this...
read moreTremella polysaccharides (TP) are the major component and activity unit of Tremella. TP have anti-aging effects by regulating transcription and expression of cell cycle negative regulator P21, anti-oxidation and strengthen immunity (Li 2004). Tremella fuciformis polysaccharide (TFP), has good stability as well as excellent moisturizing effect and antiwrinkle effect. It can improve the skin texture, lower the skin harshness and increase the skin flexibility
read moreCordyceps, as a general term, describes a group of ascomycetous fungi growing on arthropods and other related fungi. Some cordyceps have been used in traditional Chinese medicine for centuries and cordyceps-derived products are currently a big industry in China. A number of medicinal and health products have been developed and extensively commercialized from natural Chinese cordyceps, its anamorphic fungus (Hirsutella sinensis), and other fungi known as Chinese cordyceps. The lack of a defined classification system for medicinal cordyceps...
read moreCordyceps sinensis, also called DongChongXiaCao (winter worm, summer grass) in Chinese, is becoming increasingly popular and important in the public and scientific communities. This study summarizes the chemical constituents and their corresponding pharmacological actions of Cordyceps sinensis. Many bioactive components of Cordyceps sinensis have been extracted including nucleoside, polysaccharide, sterol, protein, amino acid, and polypeptide. In addition, these constituents’ corresponding pharmacological actions were also shown in the...
read morePhellinus linteus, a species of mushroom, has been shown to contribute to health benefits, such as anti-inflammatory activity and immunomodulatory efficacy. The aim of this study was to analyze the most effective constituents of P. linteus fermented broths, polysaccharides, and to evaluate their immunoregulatory effects on T cells. Four fermented broths (PL1e4) and the dialyzate medium (MD) were prepared from P. linteus mycelia, and the polysaccharide contents of each were analyzed. The P. linteus samples were tested for biological...
read moreABSTRACT: We studied the effect of the maturation stage on the chemical compositions and macrophage activation activity of polysaccharides from the culinary-medicinal mushroom Hericium erinaceus. Results showed that total polysaccharides increased, whereas protein content decreased with the maturation stage development of fruiting body. Nine polysaccharide fractions, 3 from each of the maturity stages IV (small fungal spine stage), V (mid-fungal spine stage) and VI (mature), were prepared using the gradient ethanol precipitation method. The...
read moreABSTRACT: Chronic low-grade inflammation in the adipose tissue accompanying obesity is thought to be an underlying driver of metabolic diseases. In this study, we aimed to investigate the efficacy of Hericium erinaceus on adipose tissue inflammation. The anti-inflammatory effects of the ethyl acetate soluble fraction of H. erinaceus (EAHE) were examined using cocultures of 3T3-L1 adipocytes and RAW264 macrophages. EAHE significantly suppressed tumor necrosis factor (TNF)-α and interleukin (IL)-6 production in cultured RAW264 macrophages...
read moreThe pilot study evaluated the effects of a 4-week administration of H. erinaceus (Amyloban 3399) on female undergraduate students who were likely to have a high incidence of sleep problems. We assessed the changes in asleep quality and subjective well-being with the GHQ-28 and PSQI (Pittsburgh Sleep Quality Index). Furthermore, we examined the level of salivary free-MHPG after awakening, which is generally regarded as an accurate index of chronic stress and depressive symptoms and reflects sympathetic nervous system activity. Thus, we...
read moreAccumulating evidence suggests that inflammation plays a role in the pathophysiology of depression and that anti-inflammatory substances have antidepressant effects. Amycenone is obtained from extracts of the Yamabushitake (Hericium erinaceum). The purpose of this study is to examine whether amycenone shows anti-inflammatory and antidepressant effects in an inflammation-induced mouse model of depression. First, we examined the effects of amycenone on the serum levels of the pro-inflammatory cytokine, tumor necrosis factor-α (TNF-α), and the...
read moreA variety of nutritional supplements are commercially available for the potential therapeutic purpose for dogs and other domestic animals with cancers. However, the efficacy of these supplements on those cancer-bearing animals has not been verified and remains uncertain, due to the lack of the sufficient scientific studies/data. To address this important issue, we examined actual anticancer effects of five selected commercial products on the two types of canine cancer models in vitro. Among them, PET-Fraction (PET-F) obtained from maitake...
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