REFERENCES
[#2015-03] Poria Cheng, Shujie et al. Pachymic Acid Inhibits Growth and Induces Apoptosis of Pancreatic Cancer In Vitro and In Vivo by Targeting ER Stress
Pachymic acid (PA) is a purified triterpene extracted from medicinal fungus Poria cocos. In this paper, we investigated the anticancer effect of PA on human chemotherapy resistant pancreatic cancer. PA triggered apoptosis in gemcitabine-resistant pancreatic cancer cells PANC-1 and MIA PaCa-2. Comparative gene expression array analysis demonstrated that endoplasmic reticulum (ER) stress was induced by PA through activation of heat shock response and unfolded protein response related genes. Induced ER stress was confirmed by increasing...
read more[#2015-02] Reishi Cheng, Shujie et al. Ganoderma lucidum for Cancer Treatment: We Are Close but Still Not There
The medicinal fungus Ganoderma lucidum has been used in traditional Chinese medicine for millennia to improve health and promote longevity. The idea of using G. lucidum for cancer treatment is based on numerous laboratory and preclinical studies with cancer and immune cells as well as animal models demonstrating various biological activities in vitro and in vivo. For example, G. lucidum possesses cytotoxic, cytostatic, antimetastatic, anti-inflammatory, and immunomodulating activities. Limited clinical studies, including case reports and...
read more[#2015-01] Meshima Konno, Sensuke et al. Potent Anticancer Effects of Bioactive Mushroom Extracts (Phellinus linteus) on a Variety of Human Cancer Cells
Abstract Background: Although several therapeutic options are currently available for patients with various cancers, the outcomes are often disappointing and a more effective modality needs to be promptly established. We have been exploring an alternative approach using natural agents and two bioactive mushroom extracts isolated from Phellinus linteus (PL), namely PL-ES and PL-I-ES, were of our interest. As anticancer effects of similar extracts have been reported in several cancers, we investigated whether PL-ES and PL-I-ES might have...
read more[#2014-15] Coriolus Fang, Xianying et al. The synergistic beneficial effects of Ginkgo Flavonoid and Coriolus versicolor Polysaccharide for Memory Improvements in a mouse model of dementia
This study reports the combination of Ginkgo flavonoid (GF) and Coriolus versicolor polysaccharide (CVP) in the prevention and treatment of a mouse model of Alzheimer’s disease (AD). GF is a traditional health product, and CVP is the main active ingredient of the medicinal fungus Coriolus versicolor. The Morris water maze test, the Y maze, and the step-through test showed that the combinational use of CVP and GF synergistically improvedmemory in a mousemodel of AD. Based on H&E staining analysis, the combination of CVP and GF decreased...
read more[#2014-14] Reishi Gowrie S., Uma et al. Evaluation of Bioactive Potential of Basidiocarp Extracts of Ganoderma lucidum
The present study was carried out to evaluate antimicrobial potential of Ganoderma lucidum using various concentrations of chloroform extract of basidiocarp against the pathogenic Bacteria (Salmonella typhi, Baicllus subtilis, Escheriachia coli, Klebsiella pneumoniae, Pseudomonas aerunginosa) and Fungi (Aspergillus niger, Aspergillus flavus, Candida albicans, Curvularia species and Fusarium oxysporum). The study revealed that the chloroform extract of basidiocarp of G.lucidum showed antibacterial activity against S.typhi (18mm at...
read more[#2014-13] Cordyceps Seth, Richa et al. Pharmacology, phytochemistry and traditional uses of Cordyceps sinensis (Berk.) Sacc: A recent update for future prospects
This review highlights the pharmacology, biological properties and traditional uses of a very important folklore medicine, known as ‘Keeda jadi’. In nature, it is found at high altitudes of 3500-5000 m on the high Himalayan mountains in India, Nepal and Tibet. It is an entomo-fungal combination of a larva of small moth, Hepialus armoricanus and a parasite fungus Cordyceps sinensis. Cordyceps is best known medicine for increasing physical stamina and sexual functions. It has been traditionally used to treat patients with heart disease...
read more[#2014-12] Maitake Konno, Sensuke at al. Biological Significance and Medicinal Properties of the Maitake Mushroom
Maitake mushroom (Grifola frondosa) is an edible, medicinal mushroom. It has been extensively studied for the past 30 years, revealing numberous medicinal properties that could provide great health benefits. Those include various physiological benefits ranging from immunomodulatory and antitumor activities to treatment for diabetes, hypertension, hypercholesterolemia, viral infections (hepatitis B and human immunodeficiency virus), called “maitake D-fraction” and “maitake SX-fraction”. A number of scientific...
read more[#2014-11] Cordyceps, Reishi, Royal Agaricus Hahne, Jens C. et al. The effect of Cordyceps extract and a mixture of Ganoderma lucium Agaricus Blazi Murill extract on human endometrial cancer cell lines in vitro
Endometrial carcinoma is the most common gynaecological malignancy. Nevertheless there is a lack of curative therapies, especially for patients diagnosed with late stage, recurrent or aggressive disease, who have a poor prognosis. Cordyceps Sinensis, Ganoderma lucidum and Agaricus Blazi Murill are three fungi widely used in traditional Chinese medicine, and effects as adjuvants in tumour therapy have been demonstrated. However, the function and effects of these fungi in regard to endometrial cancer are not known. Three...
read more[#2014-10] Lion’s Mane Inanaga, Kazutoyo Case Report: Recovery from Schizophrenia using AmylobanⓇ3399 compounds extracted from Hericium erinaceum
Hericium erinaceum (HE) is a unique mushroom for its cognitive function improving actions. HE is known as Yamabushitake in Japanese and Lion’s Mane in English. Since the early 1990s, Kawagishi and his colleagues have been investigating the role of the compounds derived from HE in the treatment of dementia (Kawagishi et al., 1991; Kawagishi et al., 1992; Kawagishi et al., 2004; Kawagishi et al., 2008). Bioactive substances in HE have the potential to stimulate the production of NGF, repair neuronal damage and improve brain function...
read more[#2014-09] Reishi Zhang, Wenjing et al. Antiviral effects of two Ganoderma lucidum triterpenoids against enterovirus 71 infection
Enterovirus 71 (EV71) is a major causative agent for hand, foot and mouth disease (HFMD), and fatal neurological and systemic complications in children. However, there is currently no clinical approved antiviral drug available for the prevention and treatment of the viral infection. Here, we evaluated the antiviral activities of two Ganoderma lucidum triterpenoids (GLTs), Lanosta-7,9(11),24-trien-3-one,15;26-dihydroxy (GLTA) and Ganoderic acid Y (GLTB), against EV71 infection. The results showed that the two natural compounds display...
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