REFERENCES
[#2014-08] Poria Tang, Jin et al. Characterization and antioxidant activities of degraded polysaccharides from Poria cocos sclerotium
Poria cocos F.A.Wolf is a Chinese traditional medicine used to treat chronic gastritis, edema, nephrosis, gastric atony, and acute gastroenteric catarrh. Polysaccharides are the main active component of P.cocos. We obtained polysaccharides PCP-1, PCP-2, and PCP-3 from the degradation of P. cocos polysaccha-rides (PCP) with different concentrations of H2O2 solution. Molecular weights were determined by high performance size exclusion chromatography. HPLC analysis of monosaccharide composition confirmed that PCP-1, PCP-2, and PCP-3 are...
read more[#2014-07] Meshima Chen, Yi-Shyan et al. Hispolon Decreases Melanin Production and Induces Apoptosis in Melanoma Cells through the Downregulation of Tyrosinase and Microphthalmia-Associated Transcription Factor (MITF) Expressions and the Activation of Caspase-3, -8 and -9
Abstract: Hispolon is one of the most important functional compounds that forms Phellinus linteus (Berkeley & Curtis) Teng. Hispolon has antioxidant, anti-inflammatory, antiproliferative and anticancer effects. In this study, we analyzed the functions of hispolon on melanogenesis and apoptosis in B16-F10 melanoma cells. The results demonstrated that hispolon is not an enzymatic inhibitor for tyrosinase; rather, it represses the expression of tyrosinase and the microphthalmia-associated transcription factor (MITF) to reduce...
read more[#2014-06] Reishi Vazirian, Mahdi, et al. Antimicrobial Effect of the Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Higher Basidiomycetes) and Its Main Compounds
ABSTRACT: Mushrooms are considered one of the richest sources of natural antibiotics, and various species of them inhibit the growth of a wide diversity of microorganisms. Ganoderma lucidum, a well-known medicinal mushroom. has many pharmacological and biological activities including an antimicrobial effect, although few studies have investigated the antibacterial and antifungal effects of its purified compounds. The chemical structure of the purified compounds from the hexane fraction was elucidated as ergosta-7,22-dien-3β-yl acetate,...
read more[#2014-05] Maitake Freilich, Drew et al. Possible Chemosensitizing and Potent Anticancer Effects of D-Fraction in Combination with Vitamin C on Three Prevalent Urologic Cancer Cells
Chemotherapy is currently one of the most common therapeutic options for cancer patients despite the poor efficacy with considerable side effects. We then examined if D-fraction (DF), a bioactive mushroom extract, could potentiate (poor) anticancer effects of those drugs in vitro. Three urologic cancers, prostate, bladder, and kidney cancers, were tested with various chemotherapeutic drugs and their combinations with DF. Compared to individual drugs alone, combinations of drugs and DF have improved anticancer activity, resulting in the...
read more[#2014-04] Cordyceps Ji, Jing et. al Effects of Fermented Mushroom of Cordyceps sinensis, Rich in Selenium, on Uterine Cervix Cancer
1. Introduction Uterine cervical cancer is still the second most common cancer in women worldwide, despite the existence of effective screening methods [1, 2]. However, the treatment causes strong side effects such as digestive symptoms (vomiting and diarrhea) and bone marrow suppression. Thus, drugs with fewer side effects and a superior effect in combination are desired. In humans, selenium (Se) is a trace element nutrient which functions as cofactor for reduction of antioxidant enzymes such as glutathione peroxidases. Several...
read more[#2014-03] Lion’s Mane Rahman, MA et al Inhibitory Effect on In Vitro LDL Oxidation and HMG Co-A Reductase Activity of the Liquid-Liquid Partitioned Fractions of Hericium erinaceus (Bull.) Persoon (Lion’s Mane Mushroom)
Oxidation of low-density lipoprotein (LDL) has been strongly suggested as the key factor in the pathogenesis of atherosclerosis. Mushrooms have been implicated in having preventive effects against chronic diseases due especially to their antioxidant properties. In this study, in vitro inhibitory effect of Hericium erinaceus on LDL oxidation and the activity of the cholesterol biosynthetic key enzyme, 3-hydroxy-3-methyl glutaryl coenzyme A (HMG Co-A) reductase, was evaluated using five liquid-liquid solvent fractions consisting of methanol...
read more[#2014-02] Lion’s Mane Inanaga, Kazutoyo et al. Improvement of refractory schizophrenia on using Amyloban®3399 extracted from Hericium erinaceum
Introduction Nerve growth factor (NGF) is considered as a very promising candidate in the treatment of Alzheimer’s disease [1]. However, NGF is a protein that becomes inactive after oral administration. A breakthrough in treatment occurred with the discovery of a class of compounds derived from the Lion’s Mane mushroom (Yamabushitake, Hericium erinaceum), which stimulate the production of NGF [2,3]. Bioactive substances in H. erinaceum including hericenones, have the potential to repair neurological damage, improve brain function, and...
read moreBIORESEARCH UPDATE NEWS LETTER #10 Can Maitake D-Fraction Reverse Malignant Cancer Cells to Normal Cells?
Immediate Release ~ A New Gene Study Suggests Strong Clinical Implications ~ January 20, 2014- A research group of National Scientific and Technical Research Council in Argentina (CONICET) headed by Dr. Gabriela Balogh has announced that they have successfully identified genes that would be responsible for the tumor supression in human breast cancer cells (MCF-7) by a mushroom extract called Maitake D-Fraction. The results include that D-Fraction may even revert the malignancy of cancer cells by...
read more[#2014-01] Lion’s Mane Inanaga, Kazutoyo Marked improvement of neurocognitive impairment after treatment with compounds from Hericium erinaceum: A case study of recurrent depressive disorder
1.Introduction Hericium erinaceum (HE; “Yamabushitake” in Japanese) is an edible mushroom that was named after the pom-poms worn by traditional warrior monks or the Yamabushi. HE has numerous multifunctional biological activities such as suppressing endoplasmic reticulum stress, antioxidant activities, and stimulating nerve growth factor (NGF) synthesis. Several compounds extracted from HE exhibit neuro-protective activity in the brain [1234]. Our group previously reported 3 cases of mild neurocognitive disorders resulting from...
read more[#2013-24] Reishi Batra, Priya et al. Probing Lingzhi or Reishi Medicinal Mushroom
Ganoderma lucidum (Lingzhi or Reishi) is known as a bitter mushroom with remarkable health benefits. The active constituents found in mushrooms include polysaccharides, dietary fibers, oligosaccharides, triterpenoids, peptides and proteins, alcohols and phenols, mineral elements (such as zinc, copper, iodine, selenium, and iron), vitamins, and amino acids. The bioactive components found in the G. lucidum mushroom have numerous health properties to treat diseased conditions such as hepatopathy, chronic hepatitis, nephritis, hypertension,...
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