[#1998-06] Triterpenes from the Spores of Ganoderma lucidum and Their Inhibitory Activity against HIV-I Protease, Byung-Sun Min et al.
Triterpenes from the Spores of Ganoderma lucidum and Their Inhibitory Activity against HIV-I Protease
Byung-Sun Min, Norio NAKAMURA, Hirotsugu MIYASHIRO, Ki-Whan Bae, and Masao HATTORI
Two new lanostane-type triterpenes, lucidumol A and ganoderic acid β, were isolated from the spores of Reishi ( Ganoderma lucidum ), together with a new natural one and seven that were known. The structures of the new triterpenes were determined as (24S)-24,25-dihydroxylanost-8-ene-3,7-dione and 3β,7β-dihydroxy-11,15-dioxolanosta-8,24(E)-dien-26-oic acid, respectively, by chemical and spectroscopic means. The quantitative analyses of 5 fruiting bodies, antlered form and spores of G. lucidum were performed by high performance liquid chromatography and demonstrated that ganoderic alcohol and acid contents were quite high in the spore. Of the compound isolated, ganoderic acid β, (24S)-lanosta-7,9(11)-diene-3β,24,25-triol (called lucidumol B), ganodermanondiol, ganodermanontriol and ganolucidic acid A showed significant anti-human immunodeficiency virus (anti-HIV)-1 protease activity.
