[#2007-04] Effect of various natural pro...

Effect of various natural products on growth of bladder cancer cells: two promising mushroom extracts. Konno S New York Medical College; Department of Urology, Valhalla, NY Despite the availability of several therapeutic options, a safer and more effective modality is urgently needed for treatment of bladder cancer. Specific immunotherapy is effective, but severe side effects limit its clinical use and underscore the need for unconventional therapies using less toxic substances. Many natural substances are touted for their medicinal aspects and side effect profiles, and...

[#2007-03] Induction of apoptosis in SGC...

Induction of apoptosis in SGC-7901 cells by polysaccharide-peptide GFPS1b from the cultured mycelia of Grifola frondosa GF9801. Cui FJ(a), Li Y(c), Xu YY(d), Liu ZQ(e), Huang DM(a), Zhang ZC(a), Tao WY(b) a)Institute of Bioengineering, School of Food and Biotechnology, Jiangsu University, b)Laboratory of Biopharmaceutics, School of Biotechnology, Southern Yangtze University, c)Department of Plant Science, North Dakota State University, Fargo, ND,d)Department of Cereal and Food Science, North Dakota State University, Fargo, ND, e)Institute of Bioengineering, Zhejiang...

[#2006-06] Immunomodulatory Properties o...

Immunomodulatory Properties of Grifola frondosa in Submerged Culture Wu MJ(a), Cheng TL(b), Cheng SY(a), Lian TW(a), Wang LS(c), Chiou SY(d) a)Department of Biotechnology, Chia-Nan University of Pharmacy and Science, b)Taiwan Sugar Research Institute, c)Cheng-Kung University, d)Department of Health and Nutrition, Taiwan Maitake (Grifola frondosa) is a popular mushroom in Asia for its tasty flavor and immune- stimulating property. The aim of the study is to investigate the innate immunity augmentation effects of different extracts of mycelia and culture filtrate from G....

[#2006-05] Lysophosphatidylethanolamine ...

Lysophosphatidylethanolamine in Grifola frondosa as a neurotrophic activator via activation of  MAP kinase Atsuyoshi Nishina, Hirokazu Kimura, Akihiro Sekiguchi, Ryo-hei Fukumoto, Satoshi Nakajima and Shoei Furukawa ABSTRACT We found that Maitake (Grifola frondosa) extracts induced activation of mitogen-activated protein kinase (MAPK) in cultured PC12 cells, a cell line of rat pheochromocytoma cells. The active substance was isolated by a few chromatographic steps including high-performance liquid chromatography, and was identified to be lysophosphatidylethanolamine...

[#2006-04] Macrophage J774.1 cell is act...

Macrophage J774.1 cell is activated by MZ-Fraction (Klasma-MZ) polysaccharide in Grifola frondosa Masuda Y, Kodama N, Nanba H Department of Microbial Chemistry, Kobe Pharmaceutical University We previously reported that the (β-1,3)-branched (β-1,6)-glucan, MD-Fraction extracted from the fruit body of the edible maitake mushroom (Grifola frondosa) exhibits an antitumor effect. In this study, we separated a new polysaccharide from maitake, which we named Maitake MZ-Fraction (Klasma-MZ). MZ-Fraction is a β-glucan with a low molecular weight of about 20 000, which has a...

[#2006-03] Maitake Miyake, Naomi et al. ...

Low molecular weight maitake MD-Fraction (Klasma-MD) hydrolyzed with endo-β-1,6-glucanase of Trichoderma harzianum induces antitumor activities Miyake N, Masuda Y, Murata Y, Inoue M, Matuda K, Okamoto K, Nanba H, Kodama N Department of Microbial Chemistry, Kobe Pharmaceutical University We previously reported that MD-Fraction (Klasma-MD), a specific-structured β-glucan extracted from fruit bodies of maitake mushrooms (Grifola frondosa), can activate cellular immune systems and express antitumor effects. The molecular weight of the MD-Fraction ranged from 1,200,000 to...