[#2000-07] Effects of Maitake (Grifola f...

Effects of Maitake (Grifola frondosa) glucan in HIV-infected Patients Nanba, H(a), Kodama, N(a), Schar, D(b), Turner, D(b) a) Department of Microbial Chemistry, Kobe Pharmaceutical University, b) Herbal Clinical Research, London The effects of MD-Fraction, a β-glucan extracted from Maitake mushroom (Grifola frondosa), on the health status of individuals suffering from HIV infection were evaluated in a long-term trial. The HIV status of the 35 respondents who participated in the study was followed by monitoring CD4+ cell counts, viral load measure, symptoms of HIV...

[#2000-06] Suppression of D-galactosamin...

Suppression of D-galactosamine-induced liver injury by mushrooms in rats Lee EW, He P, Kawagishi H, Sugiyama K. Department of Applied Biochemistry, Faculty of Agriculture, Shizuoka University, Japan. Six species of edible mushroom were found to suppress D-galactosamine-induced enhancement of plasma alanine and aspartate aminotransferase activities when powdered mushrooms were added to the diet (5%) and fed to rats for 2 wk. Grifola frondosa ( maitake ) exhibited the most potent effect in a dose-dependent manner. A significant effect was observed only from the water-soluble...

[#2000-05] Induction of apoptosis in hum...

Induction of apoptosis in human prostatic cancer cells with β-glucan (Maitake mushroom polysaccharide) Fullerton SA, Samadi AA, Tortorelis DG, Choudhury MS, Mallouh C, Tazaki H, Konno S. Department of Urology, New York Medical College PURPOSE: To explore more effective treatment for hormone-refractory prostate cancer, we investigated the potential antitumor effect of β-glucan, a polysaccharide of the Maitake mushroom, on prostatic cancer cells in vitro. MATERIALS AND METHODS: Human prostate cancer PC-3 cells were treated with various concentrations of the highly purified...

[#2000-04] Effects of maitake (Grifola f...

Effects of maitake (Grifola frondosa) polysaccharide on collagen-induced arthritis in mice Shigesue K, Kodama N, Nanba H. Department of Microbial Chemistry, Kobe Pharmaceutical University We recently reported the anti-hepatitis effect of a polysaccharide, designated as the D-fraction, extracted from maitake. Its effect includes immuno-regulating activities. We investigated the effect of the glucan in collagen-induced arthritis (CIA). The D-fraction was administered to CIA mice for 30 consecutive days. Arthritis development was observed from the 4th day after the second...

[#2000-03] Activities of Polysaccharides...

Activities of Polysaccharides Obtained from Grifola frondosa on Insulin-dependent Diabetes Mellitus Induced by Streptozotocin in Mice Kurushima, H, Kodama, N, Nanba, H Department of Microbial Chemistry, Kobe Pharmaceutical University In an experiment with C57BL/6J model mice having insulin-dependent diabetes mellitus (IDDM) induced by streptozotocin, the glucans obtained from Maitake fruit body were found to suppress activation and proliferation of macrophages and consequently to inhibit the generation of nitric oxide (NO) and IL (interleukin)-1β, which are β-cell...

[#1999-04] Activity of Edible Mushrooms...

 Activity of Edible Mushrooms Against the Growth of Human T4 Leukemic Cancer Cells, HeLa Cervical Cancer Cells and Plasmodium falciparum Lovy, A(a), Knowles, B(b), Labbe, R, Nolan(c), L(b) a) Institute of Biological Chemistry, Washington State University, b) Department of Environmental Health Sciences, University of Massachusetts, c) Food Science Department, University of Massachusetts Several edible Hymenomycete mushroom species have been screened as possible inhibitors of human T4 leukemic cancer cells, HeLa cervical cancer cells, Plasmodium falciparum (a pyrimethamine...