[#2001-01] Effects of maitake (Grifola f...

Effects of maitake (Grifola frondosa) D-Fraction on the carcinoma angiogenesis Matsui K, Kodama N, Nanba H. Department of Microbial chemistry, Kobe Pharmaceutical University We have reported that D-Fraction extracted from maitake (Grifola frondosa), activates immune competent cells, and indicates anti-tumor activities. The D-Fraction was observed to induce angiogenesis in vivo and to enhance the proliferation capability and migration capability of human vascular endothelial cell in vitro. The D-Fraction also increased plasma vascular endothelial growth factor (VEGF)...

[#2000-09] Structures of New Ceramides f...

Structures of New Ceramides from the Fruit Bodies of Grifola frondosa Yasunori YAOITA, Takaaki ISHIZUKA, Rie KAKUDA, Koichi MACHIDA, and Masao KIKUCHI* ToKyo Pharmaceutical University, Japan. Four new phytosphingosine-type ceramides, (25,35,4R)-2-[(2'R)-2'-hydroxydocosanoylamino1-1,3,4-octade­canetriol (1), (2S,3S,4R)-2-[(2'R)-2'-hydroxytricosanoylamino]-1,3,4-octadecanetriol (2), (2S,3S,4R)-2-[(2'R)-2'- hydroxypentacosanoylamino]-1,3,4-octadecanetriol (3) and (2S,3S,4R)-2-[(2'R)-2'-hydroxyhexacosanoylamino]- 1,3,4-octadecanetriol (4), have been isolated from the fruit...

[#2000-08] Angiotensin I-Converting Enzy...

Angiotensin I-Converting Enzyme Inhibitory Peptides from Pepsin Digest of Maitake (Grifola frondosa) Ohtsuru, M(a), Horio, H(b), Masui, H(c) a) Department of Food Science and Nutrition, Mukogawa University, b) Department of Food Science and Nutrition, Nishikyushu University, c) Department of Dietary Life and Food Science, Mukogawa Women’s University Junior College Division Three peptides which inhibit angiotension I-converting enzyme were isolated from maitake (Grifola frondosa) water extract digested by pepsin. Among them,...

[#2000-07] Effects of Maitake (Grifola f...

Effects of Maitake (Grifola frondosa) glucan in HIV-infected Patients Nanba, H(a), Kodama, N(a), Schar, D(b), Turner, D(b) a) Department of Microbial Chemistry, Kobe Pharmaceutical University, b) Herbal Clinical Research, London The effects of MD-Fraction, a β-glucan extracted from Maitake mushroom (Grifola frondosa), on the health status of individuals suffering from HIV infection were evaluated in a long-term trial. The HIV status of the 35 respondents who participated in the study was followed by monitoring CD4+ cell counts, viral load measure, symptoms of HIV...

[#2000-06] Suppression of D-galactosamin...

Suppression of D-galactosamine-induced liver injury by mushrooms in rats Lee EW, He P, Kawagishi H, Sugiyama K. Department of Applied Biochemistry, Faculty of Agriculture, Shizuoka University, Japan. Six species of edible mushroom were found to suppress D-galactosamine-induced enhancement of plasma alanine and aspartate aminotransferase activities when powdered mushrooms were added to the diet (5%) and fed to rats for 2 wk. Grifola frondosa ( maitake ) exhibited the most potent effect in a dose-dependent manner. A significant effect was observed only from the water-soluble...

[#2000-05] Induction of apoptosis in hum...

Induction of apoptosis in human prostatic cancer cells with β-glucan (Maitake mushroom polysaccharide) Fullerton SA, Samadi AA, Tortorelis DG, Choudhury MS, Mallouh C, Tazaki H, Konno S. Department of Urology, New York Medical College PURPOSE: To explore more effective treatment for hormone-refractory prostate cancer, we investigated the potential antitumor effect of β-glucan, a polysaccharide of the Maitake mushroom, on prostatic cancer cells in vitro. MATERIALS AND METHODS: Human prostate cancer PC-3 cells were treated with various concentrations of the highly purified...